Evaluation of the Efficacy of Transcutaneous Electrical Acupoint Stimulation during the Treatment of Painless Colonoscopy

Objective: To investigate the clinical efficacy of transcutaneous electrical acupoint stimulation combined with propofol infusion during the treatment of patien...     

股骨转子间骨折内固定器械研究进展

股骨转子间骨折是常见的骨折,亦是当今创伤骨科的研究热点。随着对股骨转子间骨折认识的深入及手术固定材料技术的发展,目前手术内固定治疗已成为首选治疗方式,现行的手术内固定治疗方式主要有髓外固定和髓内固定两种,二者各有优势,但也存在不足。髓内固定因微创和生物力学的优势逐渐成为主流内固定治疗方式。本文就股骨转子间骨折内固定器械的设计、优缺点、临床应用及其发展等方面进行综述,以期为临床内固定选择提供参考。     

2型糖尿病共病抑郁患者静息态脑功能局部一致性

目的 采用静息态功能MRI(rs-fMRI)观察2型糖尿病(T2DM)共病抑郁(T2DD)患者静息态脑功能活动同步性异常改变及其与临床指标的相关性.方法 纳入接受认知心理量表评估及头颅M RI检查的52例T 2DD患者(T2DD组)、59例T2DM患者(T2DM组)及53名健康成人[健康对照(HC)组],记录其临床资料...     

糖尿病肢体缺血再灌注心肌损伤防治的研究进展

［摘要］　糖尿病患者机体内环境长期处于高血糖的状态。当发生肢体缺血再灌注（IR）时,相较于非糖尿病患者的组织和脏器更易受损,且程度更严重。该文就糖尿病肢体IR心肌损伤及其防治作一综述。     

A case with no administration of protamine to neutralize heparin in aortic valve replacement with cardiopulmonary bypass

Systemic heparinization is necessary before cardiopulmonary bypass (CPB) in cardiac surgery, and protamine administration to neutralize heparin for hemostasis is required at the end of CPB. Because protamine is an allogeneic protein extracted from the sperm of specific fish, serious adverse reactions can occur during clinical application, with potentially catastrophic outcomes. A male patient received aortic valve replacement with CPB. Severe allergic reactions occurred postoperatively after protamine administration for neutralization. Emergency heparinization and CPB re-establishment were conducted with no further hemostatic treatment with protamine. However, the patient suffered a massive hemorrhage and was treated symptomatically with blood transfusion and rehydration. Following two thoracotomies for hemostasis, the patient healed and was eventually discharged. Protamine is irreplaceable as the only hemostatic that neutralizes heparin for cardiac CPB at present. However, because it is an alloprotein, it can cause serious allergic reactions after entering the human body, and caution should be exercised during the process of its clinical application.     

Prognostic implications of ferroptosis-associated gene signature in colon adenocarcinoma

BACKGROUNDColon adenocarcinoma (COAD) is one of the most common and fatal malignant tumors, which increases the difficulty of prognostic predictions. Thus, new biomarkers for the diagnosis and prognosis of COAD should be explored. Ferroptosis is a recently identified programmed cell death process that has the characteristics of iron-dependent lipid peroxide accumulation. However, the predictive value of ferroptosis-related genes (FRGs) for COAD still needs to be further clarified. AIMTo identify some critical FRGs and construct a COAD patient prognostic signature for clinical utilization. METHODSThe Cancer Genome Atlas database (TCGA) and Gene Expression Omnibus databases were the data sources for mRNA expression and corresponding COAD patient clinical information. Differentially expressed FRGs were recognized using R and Perl software. We constructed a multi-FRG signature of the TCGA-COAD cohort by performing a univariate Cox regression and least absolute shrinkage and selection operator Cox regression analysis. COAD patients from the Gene Expression Omnibus cohort were utilized for verification. RESULTSOur research showed that most of the FRGs (85%) were differentially expressed between the corresponding adjacent normal tissues and cancer tissues in the TCGA-COAD cohort. Seven FRGs were related to overall survival (OS) in the univariate Cox analysis (all P < 0.05). A model with five FRGs (AKR1C1, AKR1C3, ALOX12, CRYAB, and FDFT1) was constructed to divide patients into high- and low-risk groups. The OS of patients in the high-risk group was significantly lower than that of the low-risk group (all P < 0.01 in the TCGA and Gene Expression Omnibus cohorts). The risk score was an independent prognosticator of OS in the multivariate Cox analysis (hazard ratio > 1, P < 0.01). The predictive capacity of the model was verified by a receiver operating characteristic curve analysis. In addition, a nomogram based on the expression of five hub FRGs and risk score can precisely predict the OS of individual COAD cancer patients. Immune correlation analysis and functional enrichment analysis results revealed that immunology-related pathways were abundant, and the immune states of the high-risk group and the low-risk group were different.CONCLUSIONIn conclusion, a novel five FRG model can be utilized for predicting prognosis in COAD. Targeting ferroptosis may be a treatment option for COAD.     

有晶状体眼后房屈光晶状体植入术治疗超高度近视的临床疗效

目的：观察有晶状体眼后房屈光晶状体(PC-PRL)植入术治疗超高度近视的临床疗效。

方法：回顾性病例研究。选取2021-01/2022-01于我院行PC-PRL植入术治疗的超高度近视患者36例67眼,按术前球镜度数分成两组：球镜≤-18.00D者16例30眼和球镜>-18.00D 者20例37眼。比较两组患者手术前后视力、眼压、角膜内皮细胞密度(ECD)、中央前房深度(ACD)以及术后拱高、并发症的情况。

结果：两组患者术后3mo UCVA均达到或超过术前BCVA(均P<0.05),且球镜>-18.00D组的视力提高幅度更大(P<0.01); 两组患者术后1d眼压、角膜内皮细胞密度与术前比较均有差异(均P<0.05); 术后不同时间点拱高均呈下降趋势,但均在正常范围内; 术后3mo ACD均低于术前(均P<0.01)。两组间手术前后眼压、ECD、ACD及术后拱高比较均无差异(P>0.05)。两组患者术后均未发生严重并发症。

结论：PC-PRL植入术治疗超高度近视患者早期视力得到良好改善、屈光状态稳定、安全可靠、无严重并发症。     

毛细胞白血病的治疗新进展北大核心

毛细胞白血病(hairy cell leukemia,HCL)是一种罕见的B细胞肿瘤性疾病,主要是由BRAF V600E突变引起。常规的治疗药物是克拉屈滨、喷司他汀及干扰素,疗效显著,但50%的HCL患者仍会复发,急需新的药物来联合治疗。近年来,关于HCL的临床试验层出不穷,给HCL的治疗带来新的希望。因此,本文就HCL最新的治疗进展作一综述。     

胸腔镜肺叶切除术中肺动、静脉切断顺序对非小细胞肺癌患者手术疗效与安全性影响的系统评价

Objective To systematically evaluate the effect of sequence of pulmonary artery and vein transection in thoracoscopic lobectomy on the efficacy and safety of patients with non-small cell lung cancer. Methods PubMed, EMbase, Web of Science, The Cochrane Library, CNKI, Wanfang, VIP and CBM databases were searched for the researches on The post-operative efficacy of pulmonary arteriovenous and pulmonary vein resection sequence in thoracoscopic lobectomy for non-small cell lung cancer. The retrieval time is from the database construction to May 2022. Meta-analysis was performed using RevMan 5.4 software. Results Eight articles were included, including 3 randomized controlled studies and 5 cohort studies, with a total of 1810 patients. Meta-analysis results showed that: The operative time (MD=13.34, 95%CI(7.36, 19.32), P<0.0001) and intraoperative blood loss (MD=45.29, 95%CI(40.24, 50.35), P<0.0001) in the group with priority pulmonary vein resection were significantly higher than those in the group with priority pulmonary vein resection. The difference was statistically significant. However, the benefits of OS (HR=1.34, 95%CI (1.12, 1.60), P=0.001) and DFS (HR=1.44, 95%CI(1.18, 1.76), P=0.0003) in the group of priority pulmonary vein transection were significantly better than those in the group of priority pulmonary artery transection, with statistically significant differences. Conclusion Priority pulmonary vein transection during thoracoscopic lobectomy effectively improved patients’ OS and DFS, resulting in higher survival benefit for patients with non-small cell lung cancer, but intraoperative bleeding and operation time are more than those with priority pulmonary artery transection. © 2023, CHINA RESEARCH ON PREVENTION AND TREATMENT. All rights reserved.     

间歇性外斜视儿童术后视感知觉训练对各级视功能恢复的临床观察

目的:探讨视感知觉训练在间歇性外斜视(IXT)儿童患者术后各级视功能恢复以及知觉眼位改善中的作用。方法:前瞻性临床研究。收集2022-01/06就诊于兰州市第一人民医院眼科行斜视矫正手术且完成术后3mo随访的IXT患者74例。术后1d随机将患者分为2组：训练组35例患者进行双眼视感知觉训练,对照组39例患者不进行任何训练。观察两组患者术后1d, 3mo各级视功能和知觉眼位变化情况。结果:术后1d训练组有同时视者24例(69%),术后3mo同时视功能恢复患者为34例(97%),显著高于术后1d(P=0.002);术后3mo对照组有融合功能者22例(56%)、远立体视者13例(33%)、动态立体视者20例(51%)、静态精细立体视者17例(44%),训练组有融合功能者31例(89%)、远立体视者25例(71%)、动态立体视者30例(86%)、静态精细立体视者27例(77%),均显著高于对照组(均P<0.05);训练组患者知觉眼位偏移程度较对照组下降更明显(均P<0.05)。结论:IXT儿童患者术后进行视感知觉训练可以促进各级视功能恢复,并改善知觉眼位,提高大脑知觉水平对眼位的控...