Fe/Mn Multilayer Nanowires as High-Performance T1-T2 Dual Modal MRI Contrast Agents

A lot of nanomaterials are using T₁-T₂ dual mode magnetic resonance (MR) contrast agents (CAs), but multilayer nanowire (NW) with iron (Fe) and manganese (Mn) as T₁-T₂ dual modal CAs has not been reported yet. Herein, we synthesized a Fe/Mn multilayer NW with an adjustable Fe layer, as T₁-T₂ dual-mode CAs. The relaxation performance of Fe/Mn multilayer NW was studied at 1.5 T. Results show that, when the length of the Fe layer is about 10 nm and the Mn is about 5 nm, the r₁ value (21.8 mM⁻¹s⁻¹) and r₂ value (74.8 mM⁻¹s⁻¹) of the Fe/Mn multilayer NW are higher than that of Mn NW (3.7 mM⁻¹s⁻¹) and Fe NW (59.3 mM⁻¹s⁻¹), respectively. We predict that our Fe/Mn multilayer NW could be used as T₁-T₂ dual mode MRI CAs in the near future.     

经三角肌入路微型钢板治疗单纯性肱骨大结节骨折的疗效分析

目的 探讨经三角肌入路微型锁钉钢板治疗肱骨大结节骨折的临床效果.方法 回顾性分析2016年1月至2019年1月中部战区总医院收治的采用经三角肌入路微型钢板治疗24例单纯肱骨大结节骨折患者资料.术中采用预塑形的微型锁钉钢板固定大结节骨折.随访时记录肩关节功能活动度(ROM)及并发症、Constant-Murley评分(C...     

Blocking effect of methylflavonolamine on human NaV1.5 channels expressed in Xenopus laevis oocytes and on sodium currents in rabbit ventricular myocytes

Aim:

To investigate the blocking effects of methylflavonolamine (MFA) on human Na_V1.5 channels expressed in Xenopus laevis oocytes and on sodium currents (I_Na) in rabbit ventricular myocytes.

Methods:

Human Na_V1.5 channels were expressed in Xenopus oocytes and studied using the two-electrode voltage-clamp technique. I_Na and action potentials in rabbit ventricular myocytes were studied using the whole-cell recording.

Results:

MFA and lidocaine inhibited human Na_V1.5 channels expressed in Xenopus oocytes in a positive rate-dependent and concentration-dependent manner, with IC₅₀ values of 72.61 μmol/L and 145.62 μmol/L, respectively. Both of them markedly shifted the steady-state activation curve of I_Na toward more positive potentials, shifted the steady-state inactivation curve of I_Na toward more negative potentials and postponed the recovery of the I_Na inactivation state. In rabbit ventricular myocytes, MFA inhibited I_Na with a shift in the steady-state inactivation curve toward more negative potentials, thereby postponing the recovery of the I_Na inactivation state. This shift was in a positive rate-dependent manner. Under current-clamp mode, MAF significantly decreased action potential amplitude (APA) and maximal depolarization velocity (V_max) and shortened action potential duration (APD), but did not alter the resting membrane potential (RMP). The demonstrated that the kinetics of sodium channel blockage by MFA resemble those of class I antiarrhythmic agents such as lidocaine.

Conclusion:

MFA protects the heart against arrhythmias by its blocking effect on sodium channels.     

儿童行为问题及其影响因素的Logistic回归分析

目的了解儿童的行为问题发生及其影响因素,为有效开展心理健康教育、保障儿童身心健康提供科学依据。方法随机抽取武汉市青山区437名儿童,采用Achenbach氏儿童行为量表（CBCL）和自制调查问卷进行调查,应用SPSS统计软件进行单因素和多因素logistic回归分析。结果儿童行为问题的检出率为8.2%。女孩行为问题检出率明显高于男孩（P〈0.01）,母亲职业、父母关系、学习环境、父母的态度、和父母谈心理话对儿童行为问题有影响（P〈0.05）。结论家庭、学校、社会必须关注儿童行为问题及其影响因素,采取综合措施减少儿童行为问题的发生,保障儿童身心健康。     

Ionic substitutions in calcium phosphates synthesized at low temperature

Ionic substitutions have been proposed as a tool to improve the biological performance of calcium phosphate based materials. This review provides an overview of the recent results achieved on ion-substituted calcium phosphates prepared at low temperature, i.e. by direct synthesis in aqueous medium or through hydrolysis of more soluble calcium phosphates. Particular attention is focused on several ions, including Si, Sr, Mg, Zn and Mn, which are attracting increasing interest for their possible biological role, and on the recent trends and developments in the applications of ion-substituted calcium phosphates in the biomedical field.     

Cervical spine disease and anaesthesia

The cervical spine is obliged to support and manoeuvre the heavy weight of the head (about 6 kg) throughout life. It is not surprising that arthritic and traumatic processes are common in this spinal region. Stenosis of the spinal or root canal is the most frequent reason for surgery. Instability is a vague term, with many grades of severity and clinical import. Excluding instability in unconscious patients is a common ICU problem. The cause of neurological deterioration during anaesthesia is uncertain. Airway management will remain under suspicion, but prolonged minor deformity of the cord and relative hypotension are probably to blame. Difficulty with direct laryngoscopy is frequent, particularly with upper cervical spine lesions. It is difficult to identify reduced cranio-cervical junction movement by clinical examination. Airway obstruction due to swelling of the tissues of the neck is an important complication of anterior cervical surgery. Eye damage, particularly corneal abrasion, must be avoided by obsessive care of the eyes.     

双路温热化疗治疗肺腺癌胸水的临床研究

目的　探索肺腺癌胸水的治疗方法。方法　随机选择肺腺癌胸水患者 48例作治疗组 ,采用双路胸腔温热化疗治疗 ,同时随机选择肺腺癌胸水患者 44例作对照组 ,采用常规胸腔顺铂化疗治疗。结果　治疗组有效率、中位生存期明显高于对照组 ,胃肠道副反应、骨髓抑制治疗组明显低于对照组。结论　双路温热化疗方法简单、安全 ,控制胸水生长效果明显 ,副作用小     

Cox multivariate regression analysis of recurrence factors for colonic carcinoma

Colonic carcinoma is one of the most commonmalignant tumor. There has been limited improvement insurvival following curative surgery over the previousthree decades, with local recurrence of the disease, withor without disseminated disease, remaining a particularproblem. Analysis of prognostic factors of coloniccarcinoma is helpful in identifying the people with a highrisk of postoperative recurrence. Thus individual therapyas well as comprehensive therapy can be applied. In thispaper, Cox mul…     

枕大池蛛网膜囊肿切除加分流术探讨

目的：观察囊肿切除加枕大池-腹腔分流术治疗枕大池蛛网膜囊肿的疗效。方法：对枕大池蛛网膜囊肿行囊肿切除术加枕大池-腹膜分流术。结果：所有病例术后2-3周枕大池明显缩小,12例得到随访,平均随访时间32个月。枕大池及脑室系统大小正常,无囊肿复发,症状逐渐消失,结论：囊肿切除加枕大池-腹腔分流术治疗枕大池蛛网膜囊肿,具有疗效确切,并发症少,无复发等特点。