The distribution of standard rate constants for electron transfer between thiol-modified gold electrodes and adsorbed cytochrome c

The magnitude of the total rate constant of an electrochemical reaction at small overpotentials is shown to depend on the exponentials of the distance between the electron donor and acceptor, the reorganization energy, and the formal potential of the reaction. When a population distribution of one or more of these three parameters exists, the effect on the measured standard rate constant can be illuminated by using small-amplitude a.c. electrochemical impedance spectroscopy. Assuming a Gaussian distribution of the logarithm of the standard rate constants, the results from the system of cytochrome c molecules adsorbed on thiol-modified gold electrodes yield a standard deviation of approximately 0.5 for log k°/k_avg°. The peak broadening of reversible voltammograms is related to a comparable distribution of formal potentials.     

Austenite Stability and Deformation Behavior in Medium Mn Steel Processed by Cyclic Quenching ART Heat Treatment

This study investigated the austenite stability and deformation behavior of cyclic quenching-austenite reverse transformation processed Fe-0.25C-3.98Mn-1.22Al-0.20Si-0.19Mo-0.03Nb medium Mn steel. A number of findings were obtained. Most importantly, the extent of the TRIP effect was mainly determined by an appropriately retained austenite stability rather than its content. Simultaneously, chemical elements were the key factors affecting austenite stability, of which Mn had the greatest impact, while the difference of retained austenite grain size and Mn content resulted in different degrees of retained austenite stability. Additionally, there were still large amounts of strip and granular-retained austenite shown in the microstructure of the CQ3-ART sample after tensile fracture, revealing that the excessively stable, retained austenite inhibited the generation of an extensive TRIP effect.     

连花清瘟颗粒治疗54例新型冠状病毒肺炎患者临床分析及典型病例报道

目的:分析连花清瘟颗粒治疗新型冠状病毒肺炎的临床疗效。方法:选取2020年1月1-31日在武汉科技大学附属普仁医院就诊的,应用连花清瘟颗粒联合常规治疗(根据病情监测给予营养支持治疗、抗病毒治疗及抗菌药物治疗等)的新型冠状病毒肺炎患者54例作为研究对象。结果:应用连花清瘟颗粒治疗3 d后,发热、乏力、咳嗽症状消失率分别为47.5%、35.1%、20.0%,治疗5 d后发热、乏力、咳嗽症状消失率分别为62.5%、59.5%、50.0%,治疗7 d后发热、乏力、咳嗽症状消失率分别为80.0%、75.7%、76.7%;发热、乏力、咳嗽消失天数分别为(3.6±2.14)d、(4.1±2.58)d、(5.3±2.63)d;治疗7 d后,其他症状体征(胸闷、呼吸困难、湿啰音)消失率分别为84.6%、100%、89.5%;有效率为81.6%,且临床应用安全性良好。结论:连花清瘟颗粒明显改善新型冠状病毒肺炎普通型患者发热、咳嗽、乏力等症状,减少发热、乏力、咳嗽持续天数,为临床治疗该病提供初步研究证据。     

基于有限元仿真的数字化脊柱侧弯矫形研究

目的:对脊柱侧弯患者全脊柱进行数字化信息提取,研究矫形角度与矫形力的关系,并基于CT断层扫描数据信息对患者侧弯脊柱进行三维重建,验证矫形方案的可靠性,从而为患者提供最优的个体化脊柱侧弯矫形方案。方法:根据患者CT断层扫描数据,在Matlab软件中对患者侧弯脊柱进行数字化建模,以力学原理推导矫形力与矫形角度的关系式,从而确定脊柱侧弯矫形方案。利用Mimics19.0、3-Matic等医学三维软件,对患者脊柱侧弯部分进行完整三维重建并在AnsysWorkbench中进行有限元仿真,验证矫形方案效果。结果:重建出的脊柱三维模型能够准确反映患者实际脊柱侧弯情况,Matlab软件计算得到的最优化矫形方案能够在有限元仿真中得到验证。结论:基于数字化三维重建的脊柱侧弯矫形能够针对患者个体情况提供最优化的矫形方案,辅助临床医生选择满足患者实际需求的治疗方案。     

Instrumental activation analysis of agricultural soils in maharashtra state (India) by a 252Cf neutron source

The agricultural soils from different regions in Maharashtra State were subjected to thermal neutron irradiation in a ²⁵²Cf spontaneous fission neutron source at an integrated flux of ∼10⁹ns⁻¹. The activities of the radioisotopes formed, viz. ²⁴Na, ²⁸Al, ⁴²K and ⁵⁶Mn, were measured on a multichannel analyzer coupled to a high purity germanium detector, and the content of these elements in soils was estimated by comparator method of instrumental neutron activation analysis.     

社会医疗保险配套医药卫生政策存在的问题及对策探讨

目前我国医疗保险、医疗卫生和医药行业未能同步协调发展影响了我国社会医疗保险制度的顺利实施。文章分析了我国社会医疗保险制度的相关配套医药卫生政策方面存在的问题及改进对策。     

Is caspase-3 inhibition a valid therapeutic strategy in cerebral ischemia?

Neurodegenerative diseases are characterized by progressive impairment of brain function as a consequence of ongoing neuronal cell death. Apoptotic mechanisms have been implicated in this process and a major involvement of caspase-3, a typical pro-apoptotic executioner protease, has been claimed. In this review, the role of caspase-3 in neuronal cell loss in animal models of stroke is discussed and critically evaluated. In summary, it is concluded that the biochemical evidence favoring caspase-3 as a therapeutic target in cerebral ischemia is not convincing, and the development of selective caspase-3 inhibitors for the treatment of human stroke must be viewed as high risk.