How do nurses manage their work under time pressure? Occurrence of implicit rationing of nursing care in the intensive care unit: A qualitative study

ObjectivesThe aim of this study was to explore the experience of intensive care unit nurses under time pressure and the occurrence of implicit rationing under time pressure.MethodsIn-depth audio-recorded interviews were conducted with 18 intensive care unit nurses. Colaizzi seven-step analysis of phenomenological data was used.FindingsThree themes emerged from the analysis: the influence of internal and external environments, perceived differences in time pressure, and broad coping styles.ConclusionsUnder the influence of various factors, including continuous or intermittent time pressure, nurses employ strategies to deal with the pressure. Sometimes, these strategies allow them to complete all their necessary work. However, with the increase in time pressure, sometimes some work that must be done is changed into work that should be done in the consciousness of nurses. In such cases, nurses choose the strategy of implicit rationing to deal with time pressure.     

The effect of music on delirium,pain, sedation and anxiety in patients receiving mechanical ventilation in the intensive care unit

ObjectivesTo examine the effects of music for patients under mechanical ventilation support in the intensive care unit on their delirium, pain, sedation, and anxiety.Research methodology/designA single-blind, randomized, controlled trial.SettingThe study was conducted with delirium positive patients between August 2020 and September 2021 in the medical/surgical intensive care unit of a university hospital in Turkey.MethodsThe study sample was selected through a simple and stratified randomization method; patients who met the inclusion criteria were assigned to the music, noise reduction or control group. The data were collected by using a Confusion Assessment Method for the ICU (CAM-ICU), CAM-ICU-7, Critical Care Pain Observation Tool (CPOT), Richmond Agitation-Sedation Scale (RASS), Facial Anxiety Scale (FAS), PRE-DELIRIC model, and Glasgow Coma Scale (GCS). The interventions were repeated twice a day for five days.ResultsA total of 36 patients were included, with 12 patients in each group. Significant decreases were found in the severity of delirium and pain and the level of sedation and anxiety in the music compared to the other groups (p < 0.05). The number of patients with delirium and the number of days with mechanical ventilation was found to be significantly lower in the music group compared to the other groups (p < 0.05).ConclusionMusic intervention may be used as a nursing intervention to control delirium, pain, need for sedation and anxiety in intensive care unit patients. However, additional studies with larger sample is needed to validate findings.     

高血压前期合并糖耐量减低患者血清网膜素-1和高敏C反应蛋白变化的临床研究

目的研究高血压前期合并糖耐量减低(IGT)患者高敏C反应蛋白(hs-CRP)及血清网膜素-1(Omentin-1)的改变情况。方法将在该院治疗的80例高血压前期合并糖耐量减低患者设为研究组,同期治疗的73例单纯高血压前期患者设为PH组,73例单纯糖耐量减低患者设为IGT组,72例健康体检者设为对照组。对比分析各组患者空腹血糖和血压等一般资料以及hs-CRP和Omentin-1的改变情况。结果与其他各组比较,研究组Omentin-1水平降低最为明显(P<0.05)。析因分析提示Omentin-1与血糖异常及血压均不具有交互作用;但回归分析提示Omentin-1可能受餐后2 h血葡萄糖(2h PBG)及收缩压影响。研究组hs-CRP水平升高最为明显(P<0.05)。析因分析提示hs-CRP与血糖异常及血压不具有交互作用。结论高血压前期合并糖耐量减低患者早期介入血压和血糖的控制对治疗有积极的意义,Omentin-1可能通过其抑制炎症反应而发挥其对心血管疾病的保护作用。     

Protein tyrosine phosphatase non-receptor type 12 suppresses tumor progression in osteosarcoma cells

BackgroundProtein tyrosine phosphatase non-receptor 12 (PTPN12) plays a prominent role in various cancers as a tumor suppressor. However, the expression of PTPN12 and its biological functions in osteosarcoma (OS) remains to be determined.MethodsPTPN12 expression in OS was explored in public databases and detected by immunohistochemistry and Western blot. The cell viability was determined by Cell Counting Kit-8 (CCK-8) assay and colony formation. The cell migration and invasion were assessed by the Transwell assay. Flow cytometry analysis was applied to detect cell apoptosis and cell cycle distribution. To investigate the related mechanism, the levels of EGFR and downstream proteins were detected by Western blot.ResultsPTPN12 expression was significantly decreased in OS samples in GEO database and our hospital. OS cell lines in Cancer Cell Line Encyclopedia (CCLE) database and our cultured OS cells also demonstrated low PTPN12 expression. Lentivirus-induced overexpression of PTPN12 significantly inhibited the cell viability, migration and invasion of 143B and U2OS cells. The results of flow cytometry found that PTPN12 overexpression promoted cell apoptosis and induced cell cycle arrest at G1 phase in 143B and U2OS cells. The phosphorylation levels of EGFR and subsequent proteins of the PI3K/AKT and ERK pathways were inactivated as a result of PTPN12 overexpression in OS.ConclusionPTPN12 plays a tumor suppressive role in OS cells. Restoring of PTPN12 activity may provide new insights for the treatment of this disease.     

Power Arm在隐形矫治器联合微种植钉整体内收上前牙中的作用

目的 探讨Power Arm在无托槽隐形矫治器(clear aligner,CA)联合微种植体支抗(micro-implant anchorage,MIA)整体内收上前牙中的作用.方法 建立CA联合MIA整体内收上前牙三维有限元模型,在尖牙或尖牙所对应矫治器上加入高6 mm的Power Arm,分析矫治器施力+尖牙15...