排序方式： 共有79条查询结果，搜索用时 15 毫秒
61.
目的 探讨高甘油三酯性腰围(HTGw)对糖尿病发病的独立影响以及HTGW与空腹血糖受损(ⅢG)在糖尿病发病上是否存在交互作用。方法采用队列研究的方法,以“江苏省多代谢异常和代谢综合征综合防治研究队列”资料为基础,运用logistic回归模型分析HTGW和IFG与糖尿病的关系以及评价HTGW与IFG之间的相乘交互作用;采用引入Andersson等编制的Excel表计算相加交互作用。结果 调整糖尿病的一般危险因素及基线空腹血糖(FPG)后,HTGW患者发生糖尿病的HR值为2.10(95%“：1.36～3.25)。进一步以IFG分层分析发现,无论是IFG组还是FPG正常组,HTGW均与糖尿病存在显著的联系,HR值及95hC/分别为3.09(1.70—5.61)和2.09(1.08—4.02)。将HTGW和IFG交叉分析发现,与非HTGW表型的非IFG对象相比,基线时HTGW表型的IFG患者发生糖尿病的风险最高,HR值及95%C/为12.05(6.89—21.07)。交互作用分析表明HTGW和IFG之间存在致糖尿病的相加交互作用,相对超危险度为7.00(0.49～13.51),交互作用归因比为0.57(O.32～0.82),交互作用指数为2.66(1.36～5.21)。结论 HTGW具有独立于IFG预测糖尿病发病的作用,HTGW与IFG同时存在时具有致糖尿病的相加交互作用。 相似文献
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目的 评估《职业性放射性疾病诊断总则》(GBZ 112—2017)在核工业系统内的贯彻落实情况,了解该标准科学性、实用性及实施过程中存在的问题。方法 采用调查问卷方式进行标准追踪评价,对回收的调查表进行审核,并分析数据结果。结果 核工业系统3家单位中认为标准可操作性良好,职业病诊断医师、卫生监督人员、放射工作人员对标准的知晓率分别为61.5%、88.9%、47.6%,标准的可行性评价高,配套制度和经费认知度一般,放射性疾病知识认识率低,有待进一步提高。结论 标准基本科学合理,可操作性良好,但仍需要加强实施、宣贯和培训,标准中部分机制需进一步明确。 相似文献
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《Nutrition, metabolism, and cardiovascular diseases : NMCD》2022,32(4):1045-1054
Background and aimsCardiovascular disease is the leading cause of morbidity and mortality in individuals with type 1 diabetes mellitus (T1DM). Cardiovascular risk is higher in women with diabetes than in men. With this study, we wanted to determine whether female children and adolescents with T1DM are more prone to cardiovascular risk factors (CVRFs) and an atherogenic diet than boys.Methods and resultsFor this cross-sectional study, anthropometric, clinical, biochemical, and dietary intake data of 314 children with diabetes (3–18 years; 178 boys) were analysed according to age and sex. Linear and binary logistic regression was performed to test independent associations between sex, dietary intake, and CVRFs.Low-density lipoprotein -cholesterol (LDL-c), triglyceride (TG), fibre, monounsaturated fatty acid levels (all p < 0.01), and lipid (p = 0.022) intake were higher in the girls than in the boys. Multiple regression analysis showed that LDL was associated with sex, glycated haemoglobin (HbA1c), and lipid intake percentage (R (Kannel, 1979) [2] = 0.130; p = 0.0004) independent of age, pubertal stage, body mass index (BMI), duration of diabetes, energy, and fibre intake. Logistic regression analysis showed that high LDL-c levels were present more often in girls [odds ratio, OR; confidence interval, CI = 2.569 (1.178–5.604); p = 0.018] who had a higher dietary lipid intake percentage [OR (CI) = 1.089 (1.011–1.173); p = 0.025].ConclusionsGirls with diabetes have higher LDL-c levels associated with higher dietary lipid intake. Our findings suggest that young people with diabetes, especially girls, may benefit from early dietary interventions to reduce their cardiovascular risk. 相似文献
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Chong Shen Jinbo Wen Xiaoqun Pan Jian Su Wencong Du Enchun Pan Qin Zhang Ning Zhang Hongyan Sheng Chunlan Liu Hui Wang Ming Wu Yu Qin 《Journal of diabetes and its complications》2018,32(7):623-629
Objective
To investigate the influence of age at menarche (AM) and age at natural menopause (ANM) on glycemic control in patients with type 2 diabetes mellitus (T2DM).Methods
A cross-sectional study was undertaken in Jiangsu, China. Logistic regression was used to evaluate the association between AM/ANM and glycemic control.Results
1195 (14.3%) premenopausal and 7149 (85.7%) postmenopausal women were included in this study. With the increase of AM per 1?year, patients had a low risk of uncontrolled FPG (≥7?mmol/L) and uncontrolled HbA1c (≥7%), as well as poor glycemic control (FPG ≥7?mmol/L and HbA1c ≥7%) after adjusting for age and BMI (model I, P?<?0.05) with odds ratio (OR) 0.965, 0.978 and 0.962 respectively. Whereas after adjusting for age, BMI, education, duration of diabetes, smoking, drinking and antidiabetic treatment (model II) as well as further plus diabetic familial history and physical activity (model III), the association between AM and glycemic control was not significant (P?>?0.05). Compared with premenopausal women, postmenopausal women had a low risk of uncontrolled FPG and uncontrolled HbA1c after adjusting for confounders in model II (P?<?0.05). Furthermore, both patients with early ANM (<45?years) and late ANM (>55?years) had a high risk of uncontrolled HbA1c as well as poor glycemic control even adjusted for full confounders in model III (P?<?0.05 for all).Conclusion
Early AM, early and late ANM were significantly associated with worse glycemic control. Ascertaining the AM and ANM in women with T2DM may help to identify the risk predisposed to worse glycemic control. 相似文献65.
目的了解0～12月龄婴儿分娩孕周对身长变化率与体重变化率的影响。方法基于2002-2012年昆山市淀山湖镇妇幼保健信息数据,排除其他因素后共纳入1 405例婴幼儿。出生体重与身长来源于出生证,12月龄身长与体重由主检医师测量并记录。采用一般线性模型比较身长变化率与体重变化率在出生孕周之间差异,同时调整相关协变量,给出身长变化率与体重变化率的修正均数。结果调整相关协变量后,早产、足月产、过期妊娠组修正后身长变化率分别为(2.5±0.1)、(2.1±0.0)、(2.1±0.1)cm/月,随孕周增加而呈现下降趋势,早产组明显高于足月产及过期妊娠组;修正后体重变化率分别为(0.6±0.0)、(0.6±0.0)、(0.5±0.0)kg/月,不同孕周组间差异有统计学意义,且随孕周增加而呈下降趋势。各组婴幼儿长至12月龄,未发现其身长、体重间存在统计学差异。结论早产儿在出生后呈现快速的生长,至12月龄身长与体重与足月产婴儿相当。 相似文献
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目的掌握苏州市相城区传染病流行特征及规律,为制定防治措施和策略提供科学依据。方法采用描述流行病学方法,对相城区2006—2010年甲乙类传染病疫情资料进行统计分析。结果 2006—2010年相城区甲乙类传染病年均发病率为139.88/10万,年均死亡率为0.34/10万,年均病死率为0.24%。该地区前5位的传染病依次为肺结核(41.32/10万)、梅毒(25.15/10万)、淋病(20.54/10万)、麻疹(18.87/10万)和病毒性肝炎(18.20/10万)。结论呼吸道传染病、血源和性传播疾病仍是当前危害居民健康的主要病种,应予以重点预防和控制。 相似文献
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Qiong Wu Bo Zhang Ziheng Wang Xinyi Hu Yidan Sun Ran Xu Xinming Chen Qiuhong Wang Fei Ju Shiqi Ren Chenlin Zhang Fuwei Qi Qianqian Ma Qun Xue You Lang Zhou 《Pathology, research and practice》2019,215(5):1038-1048
Background and objective
The underlying molecular mechanisms of gastric cancer (GC) have yet not been investigated clearly. In this study, we aimed to identify hub genes involved in the pathogenesis and prognosis of GC.Methods
We integrated five microarray datasets from Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) between GC and normal samples were analyzed with limma package. Gene ontology (GO) and KEGG enrichment analysis were performed using DAVID. Then we established the protein-protein interaction (PPI) network of DEGs by the Search Tool for the Retrieval of Interacting Genes database (STRING). The prognostic analysis of hub genes were performed through Gene Expression Profiling Interactive Analysis (GEPIA). Additionally, we used real-time quantitative PCR to validate the expression of hub genes in 5 pairs of tumor tissues and corresponding adjacent tissues. Finally, the candidate small molecules as potential drugs to treat GC were predicted in CMap database.Results
Through integrating five microarray datasets, a total of 172 overlap DEGs were detected including 79 up-regulated and 93 down-regulated genes. Biological process analysis of functional enrichment showed these DEGs were mainly enriched in digestion, collagen fibril organization and cell adhesion. Signaling pathway analysis indicated that these DEGs played an vital in ECM-receptor interaction, focal adhesion and metabolism of xenobiotics by cytochrome P450. Protein-protein interaction network among the overlap DEGs was established with 124 nodes and 365 interactions. Three DEGs with high degree of connectivity (NID2, COL4A1 and COL4A2) were selected as hub genes. The GEPIA database confirmed that overexpression levels of hub genes were significantly associated with worse survival of patients. Finally, the 20 most significant small molecules were obtained based on CMap database and spiradoline was the most promising small molecule to reverse the GC gene expression.Conclusions
Our results indicated that NID2, COL4A1 and COL4A2 could be the potential novel biomarkers for GC diagnosis prognosis and the promising therapeutic targets. The present study may be crucial to understanding the molecular mechanism of GC initiation and progression. 相似文献68.
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目的探讨苏州市部分国家工作人员吸烟行为的影响因素。方法对苏州市31家单位的2106名国家工作人员进行现场问卷调查,运用非条件Logistic回归分析法进行各有关吸烟影响因素的分析。结果 2106名调查对象的总吸烟率为23.8%,其中男性吸烟率为37.8%,女性吸烟率为1.1%。多因素Logistic分析显示,女性是吸烟行为的保护因素,其OR为0.03;随着年龄的上升发生吸烟行为的危险升高,其中大于55岁的风险最大,其OR为8.31;随着文化水平的升高发生吸烟行为的危险降低,其中大专/本科及研究生水平的风险最低,其OR分别为0.23和0.24。知晓吸烟/二手烟危害发生吸烟行为的OR分别为0.27和0.19;在单位和来访者中彻底执行控烟规定可以降低吸烟行为的发生,其OR分别为0.67和0.66。结论苏州市国家单位工作人员的吸烟率较高,吸烟行为的发生与多种因素有关,较高的文化水平、知晓烟草危害和严格执行控烟规定均可以显著降低国家工作人员吸烟行为的发生。 相似文献