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Complete genome sequence analysis identifies a new genotype of brassica yellows virus that infects cabbage and radish in China 总被引:2,自引:0,他引:2
Xiao-Yan Zhang Hai-Ying Xiang Cui-Ji Zhou Da-Wei Li Jia-Lin Yu Cheng-Gui Han 《Archives of virology》2014,159(8):2177-2180
For brassica yellows virus (BrYV), proposed to be a member of a new polerovirus species, two clearly distinct genotypes (BrYV-A and BrYV-B) have been described. In this study, the complete nucleotide sequences of two BrYV isolates from radish and Chinese cabbage were determined. Sequence analysis suggested that these isolates represent a new genotype, referred to here as BrYV-C. The full-length sequences of the two BrYV-C isolates shared 93.4–94.8 % identity with BrYV-A and BrYV-B. Further phylogenetic analysis showed that the BrYV-C isolates formed a subgroup that was distinct from the BrYV-A and BrYV-B isolates based on all of the proteins except P5. 相似文献
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Lun Suo QingGang Meng Yan Pei XiangWei Fu YanPing Wang Thomas D. Bunch ShiEn Zhu 《Journal of assisted reproduction and genetics》2010,27(12):735-741
Purpose
To determine the effect of cryopreservation on acH4K12 in oocytes and their respective zygotes. 相似文献55.
Cordycepin is known to have many pharmacological effects such as anti-tumorigenic, anti-inflammatory and anti-angiogenic activity. However, cordycepin induced apoptosis through the DR3 pathway in human colon cancer cells has not been studied. The effect of cordycepin on anti-proliferation was investigated in this study. Cordycepin significantly inhibited cell viability in a dose and time-dependent manner. Cordycepin increased sub G1 and G2/M phase arrest on HT-29 cells at the concentration of 100 μM, whereas cordycepin at 200 μM and 400 μM increased G1 phase arrest. Cordycepin induced apoptosis in HT-29 cells in a dose-dependent manner as detected by Hoechst and Annexin V-FITC staining. Intracellular ROS levels were higher in cordycepin treated cells as compared to control cells. The protein related to apoptosis was determined by antibody array. p53 and Bax expression increased treatment with cordycepin for 18 h. DR3, caspase-8, caspase-1, cleaved caspase-3 and cleaved PARP expression increased. These finding suggest that the cordycepin induces apoptosis through the DR3 pathway in human colon cancer HT-29. These findings suggest that cordycepin should be evaluated further as a therapeutic agent in human colon cancer. 相似文献
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Yongle Yu Jun Su Jigui Wang Ji Xi Yaping Mao Qiang Hou Xiaomei Zhang Weiquan Liu 《Virus genes》2017,53(6):876-882
Canine parvovirus (CPV) is an important and highly prevalent pathogen of dogs that causes acute hemorrhagic enteritis disease. Here, we describe a rapid method for the construction and characterization of a full-length infectious clone (rCPV) of CPV. Feline kidney (F81) cells were transfected with rCPV incorporating an engineered EcoR I site that served as a genetic marker. The rescued virus was indistinguishable from that of wild-type virus in its biological properties. 相似文献
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