Clinical-computed tomographic correlations in colloid cysts of the third ventricle

The clinical and CT findings in 12 patients with colloid cysts are described. Eleven lesions appeared hyperdense on the plain scan and only one lesion was isodense. Five of the lesions showed contrast enhancement. Ten of twelve lesions had associated hydrocephalus. Two patients with colloid cyst had no abnormal neurological findings on examination; and it is unlikely that the symptoms which led to the performance of the CT scan were related to the colloid cyst.     

中国10个地区成年人自评健康状况与全因死亡、心血管疾病死亡风险的关联研究

目的:分析自评健康状况（SRH）与全因死亡和心血管疾病（CVD）死亡风险的关联性。方法:研究对象来自中国慢性病前瞻性研究,剔除有逻辑错误和信息缺失的个体,最终纳入512 713名研究对象。SRH在基线问卷调查时搜集,包括整体自评健康状况（GSRH）及与同龄人相比自评健康状况（ASRH）;死亡事件及原因通过链接到疾病死亡...     

Features of gut microbiota in patients with anorexia nervosa

Background:Anorexia nervosa (AN) is a psychological disorder, which is characterized by the misunderstanding of body image, food restriction, and low body weight. An increasing number of studies have reported that the pathophysiological mechanism of AN might be associated with the dysbiosis of gut microbiota. The purpose of our study was to explore the features of gut microbiota in patients with AN, hoping to provide valuable information on its pathogenesis and treatment.Methods:In this cross-sectional study, from August 2020 to June 2021, patients with AN who were admitted into Peking University Third Hospital and Peking University Sixth Hospital (n = 30) were recruited as the AN group, and healthy controls (HC) were recruited from a middle school and a university in Beijing (n = 30). Demographic data, Hamilton Depression Scale (HAMD) scores of the two groups, and length of stay of the AN group were recorded. Microbial diversity analysis of gut microbiota in stool samples from the two groups was analyzed by 16S ribosomal RNA (rRNA) gene sequencing.Results:The weight (AN vs. HC, [39.31 ± 7.90] kg vs. [56.47 ± 8.88] kg, P < 0.001) and body mass index (BMI, AN vs. HC, [14.92 ± 2.54] kg/m²vs. [20.89 ± 2.14] kg/m², P < 0.001) of patients with AN were statistically significantly lower than those of HC, and HAMD scores in AN group were statistically significantly higher than those of HC. For alpha diversity, there were no statistically significant differences between the two groups; for beta diversity, the two groups differed obviously regarding community composition. Compared to HC, the proportion of Lachnospiraceae in patients with AN was statistically significantly higher (AN vs. HC, 40.50% vs. 31.21%, Z = −1.981, P = 0.048), while that of Ruminococcaceae was lower (AN vs. HC, 12.17% vs. 19.15%, Z = −2.728, P = 0.007); the proportion of Faecalibacterium (AN vs. HC, 3.97% vs. 9.40%, Z = −3.638, P < 0.001) and Subdoligranulum (AN vs. HC, 4.60% vs. 7.02%, Z = −2.369, P = 0.018) were statistically significantly lower, while that of Eubacterium_hallii_group was significantly higher (AN vs. HC, 7.63% vs. 3.43%, Z = −2.115, P = 0.035). Linear discriminant effect (LEfSe) analysis (LDA score >3.5) showed that o_Lachnospirales, f_Lachnospiraceae, and g_Eubacterium_hallii_group (o, f and g represents order, family and genus respectively) were enriched in patients with AN. Microbial function of nutrient transport and metabolism in AN group were more abundant (P > 0.05). In AN group, weight and BMI were significantly negatively correlated with the abundance of Bacteroidota and Bacteroides, while positively correlated with Subdoligranulum. BMI was significantly positively correlated with Firmicutes; HAMD scores were significantly negatively correlated with Faecalibacterium.Conclusions:The composition of gut microbiota in patients with AN was different from that of healthy people. Clinical indicators have correlations with the abundance of gut microbiota in patients with AN.     

膝关节股骨髁间切迹解剖特征用于预测非接触性前交叉韧带撕裂

目的 观察以膝关节股骨髁间切迹解剖特征预测非接触性前交叉韧带撕裂(NC-ACLT)的价值。方法 对55例NC-ACLT患者(NC-ACLT组)及55名对照者(对照组)行膝关节MR,测算髁间切迹参数(深度、宽度、深度/宽度比值、开口宽度、开口宽度指数、面积及同水平股骨髁外缘宽度)并进行组间比较;记录髁间切迹类型(A、U及W型)。采用单因素及多因素logistic回归分析筛选NC-ACLT的独立影响因素;绘制受试者工作特征曲线,计算曲线下面积(AUC),评估各髁间切迹参数预测NC-ACLT的效能。结果 NC-ACLT组髁间切迹深度及深度/宽度比值均高于、开口宽度及开口宽度指数均低于对照组(P均＜0.05)。多因素logistic回归分析显示,髁间切迹深度为NC-ACLT的独立影响因素(P＜0.05)。以髁间切迹深度29.55 mm、深度/宽度比值1.45、开口宽度21.15 mm及开口宽度指数0.29为最佳截断值,各髁间切迹参数预测NC-ACLT的敏感度分别为74.55%、58.18%、67.27%及67.27%,特异度分别为69.09%、80.00%、61.82%及78.18%,AUC分别为0.720、0.713、0.652及0.710。结论 膝关节股骨髁间切迹解剖特征可用于预测NC-ACLT,髁间切迹深度、深度/宽度比值、开口宽度及开口宽度指数可作为预测指标。     

Comparison between Piezoelectric and Piezoresistive Wearable Gait Monitoring Techniques

Insole plantar stress detection (PSD) techniques play an important role in gait monitoring. Among the various insole PSD methods, piezoelectric- and piezoresistive-based architectures are broadly used in medical scenes. Each year, a growing number of new research outcomes are reported. Hence, a deep understanding of these two kinds of insole PSD sensors and state-of-the-art work would strongly benefit the researchers in this highly interdisciplinary field. In this context, this review article is composed of the following aspects. First, the mechanisms of the two techniques and corresponding comparisons are explained and discussed. Second, advanced materials which could enhance the performance of current piezoelectric and piezoresistive insole prototypes are introduced. Third, suggestions for designing insole PSD prototypes/products for different diseases are offered. Last, the current challenge and potential future trends are provided.     

Establishment of an optimized CTC detection model consisting of EpCAM,MUC1 and WT1 in epithelial ovarian cancer and its correlation with clinical characteristics

Objective: Emerging studies have demonstrated the promising clinical value of circulating tumor cells(CTCs)for diagnosis, disease assessment, treatment monitoring and prognosis in epithelial ovarian cancer. However, the clinical application of CTC remains restricted due to diverse detection techniques with variable sensitivity and specificity and a lack of common standards.Methods: We enrolled 160 patients with epithelial ovarian cancer as the experimental group, and 90 patients including 50 pat...     

胎盘浅表血管分布类型对胎儿镜激光手术治疗双胎输血综合征术后残留吻合血管发生的影响

目的:探讨胎盘浅表血管分布类型对胎儿镜激光手术治疗双胎输血综合征（TTTS）术后残留吻合血管（RA）发生的影响。方法:回顾性分析2014年4月至2019年4月间于北京大学第三医院行胎儿镜激光凝固吻合血管术（FLOC）治疗TTTS,且最终在本院分娩的57例产妇的临床资料和分娩后胎盘灌注情况。根据术后胎盘是否发生RA分为R...     

音乐干预对住院早产儿生理指标作用的系统评价和Meta分析

目的评价音乐干预对早产儿住院期间生理指标的调节作用。方法系统检索中国知网、万方数据库、Pub Med、CINAHL、Embase和Cochrane Library数据库从建库至2017年4月18日的文献中关于音乐干预对住院早产儿(病情稳定、听力正常)生理指标作用的RCT,干预期间早产儿不接受侵入性刺激、处于平静状态,试验组给予音乐干预(音乐类型、干预时机、次数和时间不限),对照组不予音乐干预。结局指标为氧饱和度、心率和呼吸频率。采用JBI文献质量评价工具对纳入的RCT进行方法学质量评价。采用Rev Man 5.3软件进行Meta分析。结果 9篇文献符合本文的纳入标准和排除标准,质量评价后纳入5篇质量为A或B的文献(均为英文)。5篇文献均报道了氧饱和度,4篇文献报道了心率和呼吸频率。Meta分析显示,试验组和对照组氧饱和度、心率和呼吸频率差异均无统计学意义。进一步行亚组分析,根据音乐干预类型提取摇篮曲干预亚组,根据音乐实施形式的不同提取录播音乐亚组和现场演奏音乐亚组,结果显示,仅录播音乐干预组氧饱和度高于对照组[MD=0.81,95%CI:0.03~1.59),Z=2.05,P=0.04]。结论音乐干预对调节早产儿生理指标的作用不明确,鉴于该领域高质量RCT文献少,需开展更多大样本高质量的RCT进一步探讨。     

环状RNA的分子生物学功能及其在卵巢癌中的研究

环状RNA(circular RNA,circRNA)是一种在人体内广泛存在的不具有5′端帽子和3′端尾巴的共价闭合环状非编码RNA,较线性RNA更具稳定性,组织特异性强,在正常组织及肿瘤组织中的表达有显著差异,其特殊的分子生物学功能尤其是微小RNA(microRNA,miRNA)分子海绵作用,使其有望成为新的肿瘤标志物和分子靶向治疗靶标。近年研究发现circRNA可以通过多种机制调控恶性肿瘤的增殖与转移,在恶性肿瘤的早期诊断、治疗、预后以及肿瘤对放化疗敏感性等方面有指导作用。但是,目前circRNA在卵巢癌中的功能和调控机制研究尚处于初始阶段,仅有少量的报道和研究。综述circRNA的分子生物学功能及其在卵巢癌中的功能和调控机制。