膝关节囊性病变的磁共振影像诊断探讨

目的探讨膝关节囊性病变的磁共振影像（MRI）表现及其诊断价值。 方法回顾性分析经影像或者病理证实的56例膝关节囊性病变患者的临床及影像学资料,总结膝关节囊性病变的MRI影像学特点。 结果本组56例患者,其中关节周围滑膜囊肿22例（腘窝囊肿13例,鹅足囊肿6例,浅髌下滑囊囊肿3例）,交叉韧带囊肿9例,半月板囊肿11例,骨端关节面下囊性病灶14例。MRI表现囊性病灶有各自的发病部位,呈长T1、长T2信号,PDWI-FS序列呈高信号。 结论MRI能够清晰的显示膝关节囊性病变信号特点、部位、形态及病灶与周围结构的关系,对临床诊断和治疗有重要的价值。     

Protection of tight junction between RPE cells with tissue factor targeting peptide

AIM: To investigate the effect of tissue factor targeting peptide (TF-TP) on retinal pigment epithelium (RPE) cells tight junctions. METHODS: Cell counting kit-8 (CCK-8) was used to measure the proliferation of ARPE-19 cells. Expression of tight junction, ZO-1 in ARPE-19 cells was measured by Western blot and immunofluorescent staining. Western blot was also used to detect the expression of tissue factor (TF). CEC Transmigration Assay was used to measure the migration of ARPE-19 cells. The transport of fluorescent markers [fluorescein isothiocyanate dextrans of 4, 10, 20 (FD4, FD10, FD20)] and the transepithelial electrical resistance (TEER) were used to measure in ARPE-19 cell. RESULTS: CCK-8 assay showed that 5 μmol/L TF-TP can inhibit ARPE-19 cells abnormally proliferation stimulated by lipopolysaccharide (LPS; P<0.05). LPS increased the transport of fluorescent markers (FD4, FD10, FD20) and decreased TEER levels in ARPE-19 cells, respectively, which were prevented by 5 μmol/L TF-TP pretreatment (P<0.05). Furthermore, LPS significantly up-regulated the expression of TF and downregulated the expression of ZO-1 (P<0.05) in ARPE-19 cell which was inhibited by the TF-TP (P<0.05). In addition, TF-TP inhibited the abnormal migration induced by LPS in ARPE-19 cell (P<0.05). CONCLUSION: Our findings suggest that TF-TP suppressed proliferation and migration of ARPE-19 cells induced by LPS, and maintained the RPE tight junctions through inhibition of TF expression and increased expression of ZO-1.     

髓系细胞触发受体-1在人卵巢癌组织中的表达及其与淋巴结转移的相关性研究

目的:通过检测髓系细胞触发受体-1(TREM-1)在人卵巢癌组织中的表达及其与淋巴转移的相关性,探讨其参与调控肿瘤相关性炎症的可能机制。方法:选择2010年10至2011年10月南昌大学第一附属医院收治的卵巢癌患者30例与卵巢良性肿瘤患者20例。免疫组织化学法测定TREM-1在卵巢癌和卵巢良性肿瘤组织中的表达;用CD163标记M2型肿瘤相关巨噬细胞(TAMs);用D2-40标记微淋巴管,计算微淋巴管密度(LMVD)。分析TREM-1表达与卵巢癌临床病理资料的相关性。结果:卵巢癌组织中TREM-1蛋白的阳性表达率为100%,强阳性表达率为70%(21/30),阳性率显著高于卵巢良性肿瘤的10.0%(2/20)(χ2=42.19,P=0.000)。卵巢良性肿瘤组织中TREM-1和CD163很少表达。TREM-1定位于TAMs。TREM-1表达强度与淋巴转移存在相关性(P=0.01)。Logistic回归分析示,TREM-1评分是淋巴结转移的危险因素(P=0.009)。结论:TREM-1表达于卵巢癌组织的TAMs,其调控的炎症可能在促进卵巢癌淋巴转移中起着重要作用。     

早期原发闭角型青光眼合并白内障的两种手术方式临床观察

目的 分析单纯超声乳化和超声乳化联合虹膜周边切除对早期原发闭角型青光眼合并白内障的临床治疗效果。方法 选择仅局部用药即可控制眼压在正常范围的早期闭角型青光眼合并白内障患者34例（38眼），随机分组，分别施以单纯超声乳化和超声乳化联合虹膜周边切除手术（各19眼）。结果 两种术式都显著改善了视力（经x^2检验，P〈0．01）；视力改善与采用何种术式无关（经x^2检验，P〉0．05）。术前术后眼压差异无显著性，但术前17眼需药物协助控制眼压，术后观察期内无一例眼压升高需使用降眼压药物者。两种术式都显著改善了房角粘连（经x^2检验，P〈0．01）。周边前房深度术前术后差异有非常显著性（经t检验，P〈0．01）；两种术式问差异无显著性（经t检验，P〉0．05）。中央前房深度术前术后差异有非常显著性（经t检验，P〈0．01），两种术式间差异无显著性（经t检验，P〉0．05）。结论 对于早期原发闭角型青光眼合并白内障患者采取单纯超声乳化和超声乳化联合虹膜周边切除手术治疗均可以控制眼压，改善视力，但单纯超声乳化术术后并发症少，而且手术操作简单。     

联合应用热淋清治疗慢性前列腺炎的疗效观察

目的：探讨联合应用热淋清颗粒等药物治疗慢性前列腺炎的临床疗效。方法：采用随机对照临床观察的研究方法将慢性前列腺炎137例（其中细菌性前列腺炎24例,非细菌性前列腺炎113例）分为单纯化学药对照组（52例）和热淋清颗粒治疗组（85例）。对照组应用敏感抗生素、α1受体阻滞剂及温水坐浴等物理治疗;治疗组在上述治疗基础上,同时服用热淋清颗粒4g,每日3次。采用美国国立卫生研究所（NIH）制定的前列腺炎症状评分标准（CPSI）和两杯判定试验（PPMT）法及细菌学检查结果进行分析及疗效评价。结果：137例平均随访8.3个月,治疗前后进行NIH-CPSI、PPMT及细菌学检查结果比较。治疗组痊愈14.1%（12/85）、显效55.3%（47/85）、有效20%（17/85）、无效10.6%（9/85）。治疗前后NIH-CPSI分别为27.7（28.5±4.2）及13.2（12.9±3.6）,治疗前后比较差异有统计学意义（P〈0.01）。对照组痊愈7.7%（4/52）、显效17.3%（9/52）、有效46.2%（24/52）、无效28.8%（15/52）。治疗前后NIH-CPSI分别为27.2（27.8±3.6）及17.3（17.54±2.7）,治疗前后比较差异无统计学意义（P〉0.05）。治疗前后PPMT总有效率（WBC转为正常）治疗组与对照组分别为68.2%和34.6%,两者比较差异有统计学意义（P〈0.05）。但两组治疗后细菌培养转阴率差异无统计学意义（P〉0.05）。结论：联合应用热淋清颗粒及化学药治疗慢性前列腺炎可迅速改善症状,疗效显著。     

Spatial Distribution of Polycyclic Aromatic Hydrocarbons from Lake Taihu,China

A total of 30 sediments, overlying water and porewater samples were collected from Lake Taihu, China for the analysis of PAHs. The total PAHs varied from 209 to 3,843 ng g⁻¹ in sediments, from 238 to 7,422 ng L⁻¹ in overlying water and from 2,012 to 19,899 ng L⁻¹ in porewater, respectively. There are good correlations between sediment-porewater/sediment-overlying water partition coefficients and PAHs’ logKow values, with correlation coefficient of 0.94 and 0.95, respectively. The sediment PAHs in Lake Taihu originated from both pyrolytic and petrogenic sources, showing a mixed input pattern. Based on the numerical effect-based sediment quality guidelines of the United States, the sediments from Lake Taihu causing adverse effects by PAHs should have potential biological impact, but should have no impairment.     

土壤/尘健康风险评价中的暴露参数

该文在参考美国暴露参数手册及国内外相关研究的基础上,总结了土壤/尘摄入率及皮肤黏附系数的研究方法,阐述不同土壤/尘摄入人群的分级定义,并对国外报道中各类人群土壤/尘摄入率及不同情境下的土壤/尘-皮肤黏附系数进行了归纳,为土壤暴露相关的健康风险评价提供资料参考。     

Study on ambient air quality in Beijing for the summer 2008 Olympic Games

With the coming/approaching of the Olympic Games in 2008, air pollution in Beijing attracts the attention of government and people. The objective of this study is to define the air quality during the Olympic Games; we conducted the observation of SO₂, NO, CO, NO₂, O₃, and PM₁₀ from August 7 to September 30 in 2007 in Beijing. The results showed that the average daily concentrations of SO₂, NO₂, CO, and PM₁₀ during observation were 0.024, 0.072, 2.25, and 0.19 mg m⁻³, respectively. Compared with the National Ambient Air Quality Standard II, the concentrations of SO₂ and CO in the observation were low, the concentration of NO₂ basically satisfied the National Ambient Air Quality Standard II, and the concentrations of O₃ and PM₁₀ were much higher than the values of the standard. The characteristics of diurnal variation of NO, NO₂, CO, and PM₁₀ were similar, and the lower concentrations of these pollutants were observed by day and the higher concentrations at night. The concentration of SO₂ in the daytime was a little higher than that at night. The highest 1-h concentration of O₃ occurred at 14:00 local time.     

北京市农村居民人均医疗费用及影响因素分析

目的 分析2008年北京市农村居民家庭医疗费用支出情况等信息,为卫生部门了解北京农村医疗服务状况及制定相关政策提供参考依据。方法 对北京市农村居民进行问卷调查并对问卷信息进行统计分析。结果 北京市农村居民2周患病率为183.3‰,2周就诊率为112.2‰,人均年医疗费用支出为798.01元;人均医疗费用支出占人均年收入的12.60%;医疗费用中次均门诊费用为370.21元,年人均门诊费用为331.71元,次均住院费用为7335.60元,人均住院费用为12005.57元;收入、文化程度、医疗保障、家庭人员构成等因素对人均年医疗费用有一定影响。结论 北京市农民医疗状况明显改善,但医疗负担仍然较重,新农合受到普遍欢迎,基层卫生服务需要加强。