The influence of processed total non-forward and non-motile sperm count on the outcome of artificial insemination with the husband’s semen

BackgroundArtificial insemination with the husband’s semen (AIH) is an economical and noninvasive method of infertility treatment. However, AIH’s pregnancy rate is much lower than in vitro fertilization (IVF) as its multiple and complex uncertainty factors. Semen quality has been one of the main factors which affect the pregnancy outcome of AIH.MethodsThe relevant parameters of 1,142 AIH cycles were retrospectively studied, including the general parameters and the semen quality parameters among clinical pregnancy, biochemical pregnancy, non-pregnancy group, age, infertility duration, infertility type, body mass index (BMI), cycle count, morphology in previously semen examination, and semen quality parameters on the day of AIH.ResultsThe statistically significant difference was only found on processed total non-forward and non-motile sperm count (N-TFMSC). The mean processed N-TFMSC in the biochemical pregnancy group was 6.37±4.27 million, significantly higher than the other two groups (vs. 4.40±3.15 million or vs. 4.48±3.60 million, P<0.05). The study was then divided into two groups according to processed N-TFMSC, Group 1 ≤5.0 million, and Group 2 >5.0 million. A statistical increase in biochemical pregnancy rate was observed when the processed N-TFMSC was >5.0 million (2.72% vs. 0.90%).ConclusionsProcessed N-TFMSC may be one of the independent factors on AIH’s outcome; it should be given equal attention the same as processed total forward motile sperm count (TFMSC).     

微创锁定加压接骨板内固定治疗胫骨骨折

臀肌挛缩症的手术治疗方法较多,我们采用大转子后上方双侧小“S”微创切口,每侧切口长约2~3 cm,对挛缩组织进行切断,广泛松解,重症患者行臀中小肌“Z”形延长,松解髋关节囊,并行屈膝屈髋、交叉架腿、划圈征等各项指标评价,配合术后早期功能锻炼治疗,效果满意,1997-2005年8月,共收治2 518例患者,重点研究讨论其病因、分类及治疗。1临床资料1·1诊断臀肌挛缩症的诊断包括病史,特别是婴儿期臀部反复肌肉注射史,特有的外“八”字步态,并膝下蹲困难,站立时的尖臀征,快步行走或跑步时呈跳步征。臀部触诊时可触及索带硬块,划圈征、二郎腿试验及平…     

疏肝和胃降逆汤联合雷贝拉唑治疗肝胃不和证反流性食管炎患者的疗效

目的：探究疏肝和胃降逆汤加减联合雷贝拉唑治疗肝胃不和证反流性食管炎（RE）患者的临床疗效。方法：选取莆田市涵江区中医院2021年2月至2022年2月期间收治的100例肝胃不和证RE患者,随机分为对照组与观察组,各50例。对照组患者采用雷贝拉唑、莫沙必利治疗,观察组患者采用疏肝和胃降逆汤加减联合雷贝拉唑治疗。比较两组患者的临床疗效、中医证候积分、血清相关指标及6个月复发率。结果：观察组患者治疗总有效率为94.00%,高于对照组的76.00%,差异具有统计学意义（P <0.05）。治疗后观察组患者各项中医证候积分低于对照组,差异具有统计学意义（P <0.05）。治疗后观察组患者血清胃动素（MTL）、胃泌素（GAS）水平高于对照组,生长抑素（SS）水平低于对照组,差异具有统计学意义（P <0.05）。治疗后观察组患者血清白细胞介素–1β(IL–1β)、IL–2、瘦素（Leptin）、降钙素基因相关肽（CGRP）水平低于对照组,差异具有统计学意义（P <0.05）。随访6个月,观察组失访4例,对照组失访3例。观察组患者6个月复发率为2.13%,低于对照组的18.42%,...     

股骨近端解剖锁定板与动力髋螺钉治疗股骨粗隆间骨折的疗效对比分析

目的 评价股骨近端解剖锁定板与动力髋螺钉治疗股骨粗隆间骨折的疗效.方法 回顾分析2007年7月～2009年1月收治并随访的58例股骨粗隆间骨折患者,分别采用股骨近端解剖锁定板(LPFP)和动力髋螺钉(DHS)进行治疗,根据Evans分型,其中Evans Ⅰ、Ⅱ型23例,采用LPFP固定8例,采用DHS固定15例;EvansⅢ、Ⅳ、Ⅴ型35例,采用LPFP固定22例,采用DHS固定13例,分别从术中情况、术后恢复及术后患髋功能进行分析比较.结果 手术时间、术中及术后出血量、术后患髋关节功能LPFP组与DHS组有明显差异(P＜0.05),即两组相比LPFP 组手术时间短,术中出血量少及术后引流量少,术后髋关节功能恢复好,但住院费用费用高;两组的切口长度、术中透视次数和骨折愈合时间相当(P＞0.05).结论 对于Evans Ⅰ、Ⅱ型两种固定方法均可,但对于EvansⅢ、Ⅳ、Ⅴ型股骨近端解剖锁定板明显优于动力髋螺钉.     

胰腺假性囊肿治疗方法的选择

该文报告２３例胰腺假性囊肿,根据病期、囊肿大小、部位选择治疗方法,其中非手术治疗５例,外引流１例,内引流１４例,囊肿切除术３例。结果：无手术死亡,非手术治愈５例,外引流术后胰瘘１例,囊肿切除术后复发１例,内引流术后无严重并发症出现。我们认为急性囊肿应观察６周,有些病例有自行消散的可能,慢性囊肿一经确诊即可行内引流治疗,内引流是目前较理想的有效手术方式     

急性颅脑伤术后再次开颅手术临床分析

目的:探讨急性颅脑伤术后再次出血行二次手术的原因与对策。方法:回顾性分析急性颅脑伤术后再次出现颅内血肿者28例。结果:根据格拉斯哥预后量表(GOS)评分:恢复良好者12例,中残3例,重残3例,植物生存1例,死亡9例。结论:能否预防颅脑外伤术后再次出血及早期诊断、及时手术治疗是提高患者生存率及生存质量的关键。     

肺良性转移性平滑肌瘤的临床病理研究及文献回顾

目的:研究发生于肺的良性转移性平滑肌瘤(BML)的临床病理特点。方法:收集本病1例,分析研究其临床表现、影像学资料、大体形态、组织学形态及免疫组化结果并查阅对照相关文献。结果:本例BML为49岁女性患者,子宫平滑肌瘤术后15年发生肺转移,无全身其他部位转移。组织形态类似于子宫平滑肌瘤,细胞无异型,未找到核分裂象,免疫组化染色结果符合子宫原发。结论:BML是一种罕见的发生于有子宫平滑肌瘤手术史的女性,肺是主要转移部位,呈激素依赖性,定期全身体检是早期发现肿瘤转移的关键。     

A randomized,controlled, multicenter contraceptive efficacy clinical trial of the intravas device,a nonocclusive surgical male sterilization

Because of unavoidable complications of vasectomy, this study was undertaken to assess the efficacy and safety of male sterilization with a nonobstructive intravas device （IVD） implanted into the vas lumen by a mini-surgical method compared with no-scalpel vasectomy （NSV）. IVDs were categorized into two types： IVD-B has a tail used for fixing to the vas deferens （fixed wing） whereas IVD-A does not. A multicenter prospective randomized controlled clinical trial was conducted in China. The study was comprised of 1459 male volunteers seeking vasectomy who were randomly assigned to the IVD-A （n = 487）, IVD-B （n = 485） or NSV （n = 487） groups and underwent operation. Follow-up included visits at the 3rd-6TM and 12~ postoperative months, The assessments of the subjects involved regular physical examinations （including general and andrological examinations） and semen analysis. The subjects＇ partners also underwent monitoring for pregnancy by monthly interviews regarding menstruation and if necessary, urine tests, There were no significant differences in pregnancy rates （0.65% for IVD-A, 0 for IVD-B and 0.21% for NSV） among the three groups （P 〉 0.05）. The cumulative rates of complications at the 12th postoperative month were zero, 0.9% and 1.7% in the three groups, respectively. In conclusion, IVD male sterilization exhibits a low risk of long-term adverse events and was found to be effective as a male sterilization method, similar to the NSV technique. IVD male sterilization is expected to be a novel contraceptive method.     

汉黄芩素与氟尿嘧啶联用抗人肝癌细胞Hep-G2作用的拮抗效应研究

目的 探讨汉黄芩素(wogonin)联合氟尿嘧啶(5-FU)对人肝癌细胞Hep-G2生长活性的影响。 方法 实验分汉黄芩素组、5-FU组、汉黄芩素+5-FU组和空白对照组,采用MTT法观察药物对肿瘤细胞体外生长活性的影响,采用流式细胞仪分析肿瘤细胞凋亡率的变化。 结果 MTT实验结果显示汉黄芩素(5、10、20、40 μmol/L)作用24、48 h后对肿瘤细胞具有一定的增殖抑制作用(P<0.05);5-FU(5、10、20、40 mg/L)作用24、48 h后对肿瘤细胞增殖有明显的抑制作用(P<0.05);与单用组对肿瘤细胞的抑制作用相比,汉黄芩素联合5-FU组的抗肿瘤作用呈相互拮抗作用(P<0.05);汉黄芩素联合5-FU给药48 h后,联合指数CI值呈现剂量依赖性,CI值随汉黄芩素浓度的加大而增大,说明随汉黄芩素浓度的加大,其拮抗5-FU抗肿瘤效应的作用也越来越明显(P<0.05)。 结论 汉黄芩素具有一定的抗肿瘤作用,但可拮抗5-FU的抗肿瘤作用,具体机制有待进一步研究。