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991.
Kaptan K Erinç K Ifran A Yildirim V Uzun M Beyan C Işik E 《American journal of hematology》2008,83(1):46-49
Levosimendan enhances cardiac contractility by increasing myocyte sensitivity to calcium, and induces vasodilatation. Although studies have evaluated the efficacy of levosimendan in heart failure, it is not clear whether it might produce functional influence on platelet response. In this study, the effect of levosimendan on platelet aggregation was investigated. Platelet function tests were performed in 12 healthy male volunteers. Three concentrations of levosimendan solution were prepared that would result in 10, 25, and 45 ng/ml levosimendan concentrations in the blood similar to that observed after clinical therapeutic intravenous application of 0.05-0.1 microg/kg/min. Each concentration of levosimendan solution and a control diluent without levosimendan were incubated with whole blood at 37 degrees C. After incubation for 15 min, aggregation responses were evaluated with adenosine diphosphate (ADP) (5 and 10 microM) and collagen (2 and 5 microg/ml) in platelet-rich plasma. Preincubation with all dilutions of levosimendan inhibited aggregation of platelets induced by ADP and collagen significantly. Levosimendan also inhibited significantly the secondary wave of platelet aggregation induced by ADP. The results showed that there was a relationship between levosimendan concentration and inhibition of platelet aggregation. In conclusion, this study with an in vitro model showed that levosimendan had a significant inhibitory effect on platelets in clinically relevant doses. 相似文献
992.
Arrhythmogenic Evidence for Epicardial Adipose Tissue: Heart Rate Variability and Turbulence are Influenced by Epicardial Fat Thickness 下载免费PDF全文
993.
Zeynep Tuna Tulin Duger Nevin Atalay-Guzel Arzu Aral Bilkay Basturk Seminur Haznedaroglu Berna Goker 《Journal of Physical Therapy Science》2015,27(4):1239-1242
[Purpose] Although oxidative stress is known to be present in rheumatoid arthritis (RA),
the effects of exercise on oxidative parameters are unknown. The aim of this study was to
investigate the effects of acute aerobic exercise on serum oxidant and antioxidant levels
in patients with RA. [Subjects and Methods] Sixteen patients with RA and 10 age-matched
healthy volunteers participated in this study. All participants wore polar telemeters and
walked on a treadmill for 30 minutes at a speed eliciting 60–75% of maximal heart rates.
Blood samples were obtained before, immediately and 24 hours after exercise and
malondialdehyde (MDA) and total sulfhydrile group (RSH) levels were measured. [Results]
Both groups had similar heart rates during the test but the treadmill speed of the RA
patients was significantly lower than that of the healthy volunteers. Serum MDA levels
were lower than in both groups immediately after exercise, with greater decrements in the
RA patients than controls. MDA levels returned to baseline 24 hours after the exercise
only in the controls; they remained low in the RA patients. There was a slight increase in
serum RSH levels after exercise compared to baseline in both groups. [Conclusion] Moderate
intensity treadmill exercise did not have any adverse effect on the oxidant-antioxidant
balance. The results suggest that such an exercise may be safely added to the
rehabilitation program of RA for additional antioxidant effects. Morever, this antioxidant
environment is maintained longer in RA patients.Key words: Aerobic exercise, Oxidative status, Rheumatoid arthritis 相似文献
994.
Implementation of evidence‐based dentistry into practice: analysis of awareness,perceptions and attitudes of dentists in the World Dental Federation–European Regional Organization zone 下载免费PDF全文
Nermin Yamalik Secil Karakoca Nemli Eunice Carrilho Simona Dianiskova Paulo Melo Anna Lella Joel Trouillet Vladimer Margvelashvili 《International dental journal》2015,65(3):127-145
Based on evidence‐based dentistry (EBD) being a relatively new concept in dentistry, the attitudes, perceptions and level of awareness of dentists regarding EBD, and perceived barriers to its implementation into daily practice, were comparatively analysed in six countries of the FDI (World Dental Federation‐Federation Dentaire Internationale)‐European Regional Organization (ERO) zone (France, Georgia, Poland, Portugal, Slovakia and Turkey). For this purpose, a questionnaire, ‘The Relationship Between Dental Practitioners and Universities’, was developed by the FDI‐ERO Working Group and applied by National Dental Associations (NDAs). A total of 850 valid responses were received, and cumulative data, comparisons between countries and potential impact of demographic variables were analysed. Regarding EBD, similar percentages of respondents reported that they ‘know what it is’ (32.8%) and ‘they practice’ (32.1%). Most respondents believed that ‘EBD is beneficial’ (89.1%); however, they had different thoughts regarding ‘who actually benefited from EBD’. Of the participants, 60% believed that ‘dentists experience difficulties in implementing EBD’. Although lack of time, lack of education and limited availability of evidence‐based clinical guidelines were among the major barriers, there were differences among countries (P < 0.05). Significant differences were also observed between countries regarding certain questions such as ‘where EBD needed to be taught’ (P < 0.05), as both undergraduate and continuing education were suggested to be suitable. Age, practice mode and years of practice significantly affected many of the responses (P < 0.05). There was a general, positive attitude toward EBD; however, there was also a clear demand for more information and support to enhance dentists’ knowledge and use of EBD in everyday practice and a specific role for the NDAs. 相似文献
995.
[Purpose] The application of kinesio taping may improve strength and performance, inhibit
and facilitate motor activity, and increase range of motion. The aim of this study was to
compare the effects of kinesio taping facilitation and inhibition applications on
spatiotemporal knee kinematics and kinetics during walking activity in healthy subjects.
[Subjects and Methods] A three-dimensional quantitative gait evaluation was performed
without tape and with, facilitation and inhibition kinesio taping application on the knee.
Sixteen healthy female college students (age, 19.7 ± 0.4 years; height, 1.64 ± 3.4 cm;
body mass, 51.5 ± 4.8 kg) participated in the study. [Results] Spatiotemporal parameters
(cadence, walking speed, stride length) were significantly different among the trials.
Knee joint sagittal plane range of motion was not different with either kinesio taping
application. Knee external flexion moment during the early stance phase decreased
significantly with facilitation kinesio taping and increased with the inhibition kinesio
taping. Knee external extension moment during the mid-stance phase increased with
facilitation kinesio taping. Knee power parameters, eccentric activity in the rectus
femoris during the pre-swing phase was significantly increased with inhibition kinesio
taping application, while eccentric activity of the hamstrings during the terminal swing
of gait was decreased. [Conclusion] These findings showed that facilitation kinesio taping
application affected the terminal stance phase and that inhibition kinesio taping
influenced the terminal swing phase compared with the no tape condition.Key words: Kinesio tape, Knee joint, Gait analysis 相似文献
996.
997.
Necessity of Keratinized Tissues for Dental Implants: A Clinical,Immunological, and Radiographic Study 下载免费PDF全文
998.
999.
Serum hsCRP and procalcitonin levels in dyspeptic patients infected with CagA‐positive Helicobacter pylori 下载免费PDF全文
1000.