TMEM88 modulates the secretion of inflammatory factors by regulating YAP signaling pathway in alcoholic liver disease

Inflammation Research - Transmembrane protein 88 (TMEM88), a new protein of increasing concern existed in cell membrane, inhibits the typical Wnt/β-catenin signaling pathway to play a...     

精神障碍患者心电图QRS波低电压异常情况及影响因素分析

目的 探究精神障碍患者心电图QRS波低电压异常情况及影响因素。方法 选取精神障碍患者300例作为研究对象,统计其一般资料及心电图QRS波低电压异常情况,分析精神障碍患者心电图QRS波低电压异常的影响因素。结果 300例精神障碍患者心电图QRS波低电压异常120例(40.00%),其中肢导联QRS波低电压65例(54.17%)、胸导联QRS波低电压45例(37.50%)、全导联QRS波低电压10例(8.33%)。120例心电图QRS波低电压异常患者均伴有不同异常心电图变化,如窦性心动过速、窦性心律不齐、窦性心动过缓、期前收缩、不完全性右束支阻滞、T波改变、ST段改变、Q-T间期延长、左心室高电压等,可单一表现或多种共存。病程、年龄、用药时间、剂量指数、抗精神病类药物均是精神障碍患者心电图QRS波低电压异常的影响因素(P<0.05)。结论 精神障碍患者心电图QRS波低电压异常高达40.00%,年龄、病程、用药时间、剂量指数、抗精神病类药物是精神障碍患者心电图QRS波低电压异常的影响因素。     

高频重复经颅磁刺激联合舍曲林对青少年抑郁症患者自伤行为的疗效

目的 探讨重复经颅磁刺激（rTMS）联合舍曲林对青少年抑郁症（DD）患者自伤行为的疗效。方法 选取皖西卫生职业学院附属医院精神科在2018年1月至2021年12月期间收治的152例伴有自伤行为的青少年抑郁症患者为研究对象,根据随机数字表法随机分为观察组（高频rTMS+舍曲林,n=76）和对照组（舍曲林,n=76）。观察组在左侧前额叶背外侧皮质区（DLPFC）给予高频rTMS(10Hz)治疗,在相同刺激部位给予对照组假刺激治疗。rTMS每周治疗5次,持续治疗4周。记录治疗前、后两组患者汉密尔顿抑郁量表-24(HAMD-24)评分、自伤行为种类及频率、不良反应等情况。结果 组内比较,对照组和观察组治疗前后HAMD-24评分、自伤行为种类、自伤频率差异有统计学意义（P<0.05）,均改善;组间比较,对照组和观察组治疗前后的HAMD-24评分、自伤行为种类、自伤频率差值差异均有统计学意义（P<0.05）,观察组改善情况优于对照组。结论 舍曲林联合高频rTMS可显著改善患者抑郁症状和自伤行为。     

抑郁症患者甲状腺素水平紊乱与生物节律之间的关系

目的 探讨抑郁症患者甲状腺激素水平紊乱和生物节律紊乱之间的关系,为患者的治疗提供参考依据。方法 连续纳入2020年6月至2022年3月在安徽省精神卫生中心就诊的抑郁症患者90例,同期纳入90例健康对照人群。比较两组对象神经精神生物节律评定晤谈（BRIAN）评定得分、血清甲状腺激素水平的差异,并分析BRIAN评分与甲状腺激素水平的相关性。结果 与对照组相比,抑郁症患者BRIAN总分、睡眠、活动、社交、进食、夜间活动、昼夜节律颠倒评分增高（P<0.05）,早晨活动评分降低（P<0.05）。抑郁症组促甲状腺激素（TSH）水平升高,四碘甲状腺氨酸（TT4）、游离四碘甲状腺氨酸（FT4）、游离三碘甲状腺氨酸（FT3）水平降低（P<0.05）。相关性分析提示,TSH水平与BRIAN总分呈正相关,TT4及FT4水平与BRIAN总分呈负相关,而TT3及FT3与BRIAN评分无相关性。线性回归分析提示,TSH水平升高、FT4水平降低是影响抑郁症患者生物节律紊乱的危险因素。结论 抑郁症患者生物节律紊乱与甲状腺功能密切相关。     

集体作业干预对儿童青少年精神分裂症病人病耻感的影响

目的探讨集体作业治疗对儿童青少年精神分裂症病人病耻感的影响。方法将33例病人随机分为2组,对照组16例进行常规的康复活动训练,观察组17例进行集中的作业治疗训练,比较2组病人训练前后的病耻感数据。结果干预后,观察组的积极效应分高于干预前（P < 0.01）,且高于对照组（P < 0.01）,观察组在干预后的病情掩饰分低于干预前（P < 0.01）;对照组在干预前后的病耻感各项评分差异均无统计学意义（P>0.05）。结论集体作业治疗能够降低儿童青少年精神分裂症病人对病情掩饰程度,使病人获得更多的积极效应。     

The promises and pitfalls of sex difference research

Funding agencies in North America and Europe are recognizing the importance of the integration of sex differences into basic and clinical research. Although these mandates are in place to improve our knowledge of health for both men and women, there have been a number of implementation issues that require vigilance on the part of funders and the research community. Here we discuss issues on simple inclusion of both sexes in studies to specialisation of sex differences with attention paid to statistics and the need for sex-specific treatments. We suggest differing mandates need to be considered regarding simple integration versus the need for studies in the specialisation of sex differences and/or the need for research that recognises the importance of male-specific or female-specific factors that influence subsequent health such as menstruation, menopause or pregnancy.     

Gender and test dependence of a type of kappa mediated stress induced analgesia in mice

1. In male mice, 80 inescapable footshocks (S-80) induce analgesic responses measured by the tail flick test that are blocked by naloxone and the kappa opioid antagonist, nor-binaltorphimine. We now study the nociceptive responses, induced after this particular stress, measured by the writhing test, the tail immersion test and a high intensity tail immersion test both in male and female mice.2. In stressed males, analgesic responses are seen in all the nociceptive tests. Naloxone (10 mg/kg) does not prevent them.3. In stressed females, in contrast with males, no analgesia is produced in the tail flick test. The writhing test and the tail immersion test registered analgesic responses that were not prevented by naloxone (10 mg/kg).4. We conclude that only the antinociceptive kappa opioid mediated component of the stress we study is strongly dependent on gender, in contrast to other types of analgesia triggered by the same stress.     

Age-related changes in the susceptibility to clofibric acid,a hypolipidemic agent,of male rat liver

Age-related changes in the susceptibility to clofibric acid were investigated in male F344 rats of 8, 52, and 117 weeks old. Hepatomegaly, decrease of serum total cholesterol and triglyceride, increase of the total cytochrome P-450 contents, induction of the activities of microsomal ω-hydroxylation and peroxisomal β-oxidation, proliferation of smooth endoplasmic reticulum and peroxisomes were detected in 8- and 52-week-old rats. In 117-week-old rats clofibric acid treatment resulted in decrease of serum total cholesterol, elevation of the activities of microsomal and peroxisomal enzymes, and slight proliferation of peroxisomes. These results suggest that the susceptibility of the male F344 rat liver to clofibric acid decreases in 117-week-old rats, though the effect is still recognizable.