合肥市65岁以上老年人抑郁焦虑症状检出率及影响因素分析

目的 分析抑郁、焦虑症状的检出率及影响因素,为积极应对老年心理健康问题,提升心理健康服务能力提供依据。方法 采用分层随机整群抽样的方法抽样,使用电子化结构式调查问卷入户现场调查,调查问卷包括基本信息、病人健康状况问卷抑郁量表和广泛性焦虑量表。抑郁焦虑症状检出率的影响因素分析采用logistic回归分析法,单因素和多因素logistic回归分析分别采用输入法和向前wald法。结果 本次研究共调查1382人,抑郁症状检出率为11.00%,焦虑症状检出率为6.95%,抑郁症状和焦虑症状同时检出率为5.72%。logistic回归分析结果发现对和子女的关系满意度（比较满意 vs. 一般满意: OR=0.193,95%CI:0.077~0.482; 非常满意 vs. 一般满意:OR=0.091, 95%CI:0.032~0.264）、患有心脏病（OR=3.715,95%CI:1.557~8.863）、患有糖尿病（OR=3.095,95%CI:1.237~7.744）和看电视（OR=0.336,95%CI:0.146~0.772）等因素影响抑郁症状检出率,焦虑症状检出率受到对和子女关系满意度（比较满意 vs. 一般满意: OR=0.719,95%CI:0.218~2.372; 非常满意 vs. 一般满意:OR=0.023, 95%CI:0.023~0.693）和看电视（OR=0.269,95%CI:0.079~0.910）等因素影响。结论 合肥市65岁以上老年人群抑郁、焦虑等心理健康问题值得引起人们重视,拥有较高的对和子女关系的满意度以及看电视是老年人抑郁、焦虑症状检出率的保护性因素,患有心脏病、糖尿病等慢性疾病患者的焦虑抑郁问题值得我们给予更多的关注。     

某三甲精神病院利培酮血药浓度监测现状及影响因素分析

目的:通过分析某三甲精神病院利培酮(risperidone,RIS)血药浓度监测(therapeutic drug monitoring,TDM)现状,探索RIS血药浓度影响因素.方法:采用回顾性分析方法,收集2019年7月至2020年7月进行RIS TDM住院患者的检测结果及相关病例资料,分析利培酮、活性代谢物9-羟...     

Modulation of attention by socio-emotional scenes in children with autism spectrum disorder

BackgroundAbnormal attentional processes to socially relevant information may underlie social impairment in Autism Spectrum Disorder (ASD). To examine how these processes are modulated by the emotional salience of the stimuli, we studied the attentional biases to social scenes (happy, sad, and threatening) in ASD children.MethodAn emotional dot-probe task was applied to children (from 6 to 12 years old) with Autism Spectrum Disorder without additional language and/or intellectual impairments (ASD; n = 25) and age/sex-matched controls (n = 25).ResultsASD children showed an attentional bias toward threatening scenes while typically developing children tended to direct their attention toward sad scenes. There were no differences between groups for happy scenes.ConclusionsThreatening situations captured greater attention in ASD individuals than in the control participants. Thus, abnormal attention to emotionally relevant situations may negatively affect the ability of ASD children to adapt cognitively and emotionally, particularly in threatening situations.     

家庭参与式绘画治疗对心境障碍青少年的影响研究

目的 探索家庭参与式绘画治疗对心境障碍青少年情绪调节及亲子关系的干预效果。方法将70例心境障碍青少年按照病区分为对照组和观察组各35例,对照组进行常规治疗护理,观察组另予家庭参与式绘画治疗干预,共8次。比较两组干预前和干预后的情绪调节与亲子关系。结果观察组干预后情绪调节量表重新评价维度得分,青少年心理韧性量表的情绪控制、积极认知和家庭支持维度得分,父母依恋量表信任、沟通维度和总分显著高于对照组,情绪调节量表表达抑制维度得分显著低于对照组（均P<0.05）。结论家庭参与式的绘画治疗可改善心境障碍青少年的情绪调节能力,增进亲子依恋度,改善家庭关系。     

新冠肺炎疫情下儿童青少年焦虑症状检出率及影响因素

目的探讨新冠肺炎(COVID-19)疫情期间居家儿童青少年焦虑症状检出率及危险因素,为给予其心理支持提供参考。方法 2020年2月13日-14日,采用电子问卷调查方式,由安徽省7～16岁的中小学生在线填写一般资料和儿童焦虑性情绪障碍筛查表(SCARED)。SCARED评分≥23分为焦虑组,SCARED评分23分为非焦虑组。采用单因素分析、二元Logistic回归分析儿童青少年焦虑症状的危险因素。结果共回收有效问卷5 392份,其中焦虑组1 045人(19. 4%),非焦虑组4 347人(80. 6%);单因素分析显示,焦虑检出率在性别、年龄、所在年级、身体健康状况、第一次了解此次疫情的途径、负面信息占比、不实信息占比上差异均有统计学意义(P均0. 05);二元Logistic回归分析显示,女生(OR=1. 423,P0. 01)、大龄儿童(OR=1. 411,P0. 01)、目前的身体状况不佳(OR=1. 620,P0. 01)、高负面信息占比(OR=1. 240,P0. 01)、高不实信息占比(OR=1. 265,P 0. 01)是儿童青少年存在焦虑症状的独立危险因素。结论新冠肺炎疫情期间居家隔离儿童青少年焦虑检出率未见明显增高,其中女性、大龄儿童、目前身体状况不佳、不良疫情信息是焦虑症状的危险因素。     

Progressive cortical and sub-cortical alterations in patients with anti-N-methyl-d-aspartate receptor encephalitis

Journal of Neurology - Advanced structural analyses are increasingly being highly valued to uncover pathophysiological understanding of anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis....     

Accelerated intermittent theta-burst stimulation broadly ameliorates symptoms and cognition in Alzheimer's disease: A randomized controlled trial

BackgroundDeficits in associative memory (AM) are the earliest and most prominent feature of Alzheimer's disease (AD) and demonstrate a clear cause of distress for patients and their families.ObjectiveThe present study aimed to determine AM enhancements following accelerated intermittent theta-burst stimulation (iTBS) in patients with AD.MethodsIn a randomized, double-blind, sham-controlled design, iTBS was administered to the left dorsolateral prefrontal cortex (DLPFC) of patients with AD for 14 days. Measurements included AM (primary outcome) and a comprehensive neuropsychological battery. Patients were evaluated at baseline, following the intervention (week 2), and 8 weeks after treatment cessation (week 10).ResultsSixty patients with AD were initially enrolled; 47 completed the trial. The active group displayed greater AM improvements compared with the sham group at week 2 (P = 0.003), which was sustained at week 10. Furthermore, higher Mini-Mental State Examination (MMSE) scores at baseline were associated with greater AM improvements at weeks 2 and 10. For the independent iTBS group, this correlation predicted improvements in AM (P < 0.001) and identified treatment responders with 92% accuracy. Most of the neuropsychological tests were markedly improved in the active group. In particular, the Montreal Cognitive Assessment and MMSE in the active group increased by 2.8 and 2.3 points, respectively, at week 2, while there was no marked change in the sham group.ConclusionIn the present study, accelerated iTBS of the DLPFC demonstrated an effective and well-tolerated complementary treatment for patients with AD, especially for individuals with relatively high MMSE scores.     

以阳性症状为主精神分裂症患者的静息态脑功能网络特征

目的:探索以阳性症状为主的精神分裂症患者的静息态脑功能网络特征。方法:纳入符合DSM-IV精神分裂症诊断标准的以阳性症状为主患者100例和70例健康成人,采用阳性和阴性症状量表(PANSS)评估患者的临床症状,并完成静息态磁共振成像扫描。通过独立成分分析(ICA)方法比较两组听觉网络、执行网络和凸显网络间的功能连接及网络内功能连接,并对两组间存在差异的脑功能连接指标与精神病性症状和认知功能得分进行相关性分析。结果:与对照组相比,患者组听觉网络与凸显网络间的功能连接增加[(0.49±0.27)vs.(0.38±0.23)],同时听觉网络与执行网络[左侧:(-0.10±0.22 vs.(0.002±0.21);右侧:(-0.05±0.24)vs.(0.05±0.21)]及凸显网络与执行网络间功能连接[(0.001±0.28)vs.(0.11±0.24)]降低。网络内功能连接分析显示,患者组听觉网络的左侧颞上回功能连接降低,以及执行网络的脑岛和顶下小叶脑区功能连接降低。相关分析发现,前凸显网络和右执行网络间的功能连接与冲动性行为呈负相关(r=-0.24,P<0.05),听觉网络和右执行...     

伴抑郁的稳定期精神分裂症患者细胞因子水平变化及其影响因素研究

背景 细胞因子水平与精神分裂症患者的症状存在相关性,同时多数精神分裂症患者在疾病进展后期会出现抑郁症状,因此精神分裂症患者伴抑郁症状与细胞因子水平的关系值得进一步探讨。目的 探讨稳定期精神分裂症伴抑郁症状患者细胞因子水平及其与临床症状的相关关系。方法 选择2018年5—12月安徽医科大学附属巢湖医院、合肥市第四人民医院和马鞍山市第四人民医院精神科收治的稳定期精神分裂症患者。采用卡尔加里精神分裂症抑郁量表（CDSS）评估患者的抑郁症状：以CDSS总分≥5分定义为抑郁。使用流式细胞仪多重液相蛋白定量技术检测患者血浆白介素（IL）-1β、IL-2、IL-6、IL-17A水平。采用Spearman秩相关分析和多元线性回归分析探讨稳定期精神分裂症患者细胞因子水平与抑郁的关系。结果 本研究共纳入111例稳定期精神分裂症患者,抑郁发生率为28.83%(32/111)。Spearman秩相关分析显示,CDSS总分与IL-1β、IL-2及IL-17A呈正相关（rs值分别为0.507、0.466、0.374,P<0.05）。多元线性回归分析结果显示,较高水平的IL-17A是稳定期精神分裂症患者伴发抑...