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Viral encephalitis is a common clinical condition. Its clinical manifestations are variable and include neurological symptoms and psychiatric abnormalities, which makes clinical diagnosis and treatment difficult. To date, there are only a few reported cases on mental symptoms of chronic viral encephalitis. We present a case of a 16-year-old male patient who was previously hospitalised and diagnosed with schizophrenia and treated with aripiprazole 15 mg/day but failed to respond. The patient was then given antiviral therapy and recovered after 2 weeks. Clinicians should be aware of the possbility that chronic mental disorders could be caused by viral encephalitis. In the future, diagnosis of chronic functional mental disorders should include viral encephalitis in the differential diagnosis. 相似文献
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Li Liang-yun Yang Chen-chen Li Su-wen Liu Yu-min Li Hao-dong Hu Shuang Zhou Hong Wang Jin-liang Shen Hang Meng Xiao-ming Li Jun Xu Tao 《Inflammation research》2020,69(8):789-800
Inflammation Research - Transmembrane protein 88 (TMEM88), a new protein of increasing concern existed in cell membrane, inhibits the typical Wnt/β-catenin signaling pathway to play a... 相似文献
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目的 探究精神障碍患者心电图QRS波低电压异常情况及影响因素。方法 选取精神障碍患者300例作为研究对象,统计其一般资料及心电图QRS波低电压异常情况,分析精神障碍患者心电图QRS波低电压异常的影响因素。结果 300例精神障碍患者心电图QRS波低电压异常120例(40.00%),其中肢导联QRS波低电压65例(54.17%)、胸导联QRS波低电压45例(37.50%)、全导联QRS波低电压10例(8.33%)。120例心电图QRS波低电压异常患者均伴有不同异常心电图变化,如窦性心动过速、窦性心律不齐、窦性心动过缓、期前收缩、不完全性右束支阻滞、T波改变、ST段改变、Q-T间期延长、左心室高电压等,可单一表现或多种共存。病程、年龄、用药时间、剂量指数、抗精神病类药物均是精神障碍患者心电图QRS波低电压异常的影响因素(P<0.05)。结论 精神障碍患者心电图QRS波低电压异常高达40.00%,年龄、病程、用药时间、剂量指数、抗精神病类药物是精神障碍患者心电图QRS波低电压异常的影响因素。 相似文献
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目的 探讨重复经颅磁刺激(rTMS)联合舍曲林对青少年抑郁症(DD)患者自伤行为的疗效。方法 选取皖西卫生职业学院附属医院精神科在2018年1月至2021年12月期间收治的152例伴有自伤行为的青少年抑郁症患者为研究对象,根据随机数字表法随机分为观察组(高频rTMS+舍曲林,n=76)和对照组(舍曲林,n=76)。观察组在左侧前额叶背外侧皮质区(DLPFC)给予高频rTMS(10Hz)治疗,在相同刺激部位给予对照组假刺激治疗。rTMS每周治疗5次,持续治疗4周。记录治疗前、后两组患者汉密尔顿抑郁量表-24(HAMD-24)评分、自伤行为种类及频率、不良反应等情况。结果 组内比较,对照组和观察组治疗前后HAMD-24评分、自伤行为种类、自伤频率差异有统计学意义(P<0.05),均改善;组间比较,对照组和观察组治疗前后的HAMD-24评分、自伤行为种类、自伤频率差值差异均有统计学意义(P<0.05),观察组改善情况优于对照组。结论 舍曲林联合高频rTMS可显著改善患者抑郁症状和自伤行为。 相似文献
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目的 探讨抑郁症患者甲状腺激素水平紊乱和生物节律紊乱之间的关系,为患者的治疗提供参考依据。方法 连续纳入2020年6月至2022年3月在安徽省精神卫生中心就诊的抑郁症患者90例,同期纳入90例健康对照人群。比较两组对象神经精神生物节律评定晤谈(BRIAN)评定得分、血清甲状腺激素水平的差异,并分析BRIAN评分与甲状腺激素水平的相关性。结果 与对照组相比,抑郁症患者BRIAN总分、睡眠、活动、社交、进食、夜间活动、昼夜节律颠倒评分增高(P<0.05),早晨活动评分降低(P<0.05)。抑郁症组促甲状腺激素(TSH)水平升高,四碘甲状腺氨酸(TT4)、游离四碘甲状腺氨酸(FT4)、游离三碘甲状腺氨酸(FT3)水平降低(P<0.05)。相关性分析提示,TSH水平与BRIAN总分呈正相关,TT4及FT4水平与BRIAN总分呈负相关,而TT3及FT3与BRIAN评分无相关性。线性回归分析提示,TSH水平升高、FT4水平降低是影响抑郁症患者生物节律紊乱的危险因素。结论 抑郁症患者生物节律紊乱与甲状腺功能密切相关。 相似文献
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《General pharmacology》1994,25(5):903-908
1. In male mice, 80 inescapable footshocks (S-80) induce analgesic responses measured by the tail flick test that are blocked by naloxone and the kappa opioid antagonist, nor-binaltorphimine. We now study the nociceptive responses, induced after this particular stress, measured by the writhing test, the tail immersion test and a high intensity tail immersion test both in male and female mice.2. In stressed males, analgesic responses are seen in all the nociceptive tests. Naloxone (10 mg/kg) does not prevent them.3. In stressed females, in contrast with males, no analgesia is produced in the tail flick test. The writhing test and the tail immersion test registered analgesic responses that were not prevented by naloxone (10 mg/kg).4. We conclude that only the antinociceptive kappa opioid mediated component of the stress we study is strongly dependent on gender, in contrast to other types of analgesia triggered by the same stress. 相似文献