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【摘要】 目的 深入了解神经梅毒在男女性之间以及有无神经症状患者之间的特征差异,为神经梅毒的防控、临床诊断与治疗提供依据。方法 回顾分析2015年6月至2019年12月安徽医科大学第一附属医院皮肤性病科131例神经梅毒住院患者的临床表现和实验室检查结果,根据性别以及神经/精神症状分组。组间比较采用独立双样本t检验或Mann?Whitney U检验,分类变量计数资料采用χ2检验和Fisher精确检验,比较不同组别之间临床特征及实验室指标差异。结果 131例患者中,无症状神经梅毒72例(无症状组),有症状神经梅毒59例(有症状组)。有症状组的既往驱梅治疗比例(10.17%)显著低于无症状组(98.61%)(OR = 0.002,P < 0.001)。男性患者和有症状患者的首诊误诊率分别为50.00%和89.83%,分别高于女性患者(24.49%,OR = 3.08,P = 0.004)和无症状患者(0,OR = 13.00,P < 0.001)。男性有症状患者比例(57.32%)显著高于女性患者(14.64%)(OR = 4.14,P = 0.003),脑脊液甲苯胺红不加热血清试验(TRUST)阳性率(52.44%)显著高于女性患者(26.54%)(OR = 3.05,P = 0.004),脑脊液总蛋白含量升高(> 0.5 g/L)者的比例(79.27%)高于女性(59.18%)(OR = 2.64,P = 0.01),脑脊液总蛋白含量[(0.76 ± 0.41) g/L]高于女性[(0.56 ± 0.25) g/L,P = 0.002],并且男性脑部核磁共振成像异常检出率(72.22%)高于女性(44.90%)(OR = 2.13,P = 0.039)。有症状女性患者的确诊年龄[(50.82 ± 9.31)岁]大于无症状女性患者[(42.30 ± 12.18)岁](P?=?0.038)。有症状神经梅毒患者脑脊液TRUST阳性率(55.93%)高于无症状患者(31.94%)(OR = 2.70,P = 0.006),脑脊液总蛋白水平[(0.79 ± 0.46) g/L]显著高于无症状患者[(0.60 ± 0.24) g/L,P = 0.003]。结论 神经梅毒首诊误诊率高;男性患者病情较女性患者严重;既往驱梅治疗史、性别和年龄因素在神经梅毒病程发展过程中可能起一定作用。 相似文献
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目的探讨抑郁症病人睡眠结构特征及其与前瞻性记忆的相关性。方法选取 2017年 1月至 2020年 1月安徽省精神卫生中心 113例住院抑郁症病人作为抑郁组,同期该中心公开招募 47例健康者作为对照组,两组对象均行多导睡眠监测,评估汉密尔顿抑郁量表( HAMD)、汉密尔顿焦虑量表( HAMA)、基于事件的前瞻性记忆( EBPM)和基于时间的前瞻性记忆( TBPM),分析抑郁症病人睡眠结构与 EBPM和 TBPM的关系。结果相比于对照组,抑郁组快速眼动睡眠( REM)潜伏期( 235.52±83.65)min和卧床时间 507.00(49.25)min较对照组 REM潜伏期( 137.78±56.23)min和卧床时间 483.80(54.50)min长( P<0.05);抑郁组 EBPM评分 2.00(5.00)分和 TBPM评分 2.00(4.00)分较对照组的 EBPM 6.00(5.00)分和 TBPM 5.00(5.00)分少( P<0.05)。相关性分析显示,抑郁组 N2潜伏期与 TBPM呈正相关[ β=0.041,95%CI:(0.008,0.074)],REM持续时间与 TBPM呈正相关[ β=0.024,95%CI:(0.010,0.039)]。模型加入性别、年龄、文化、体质量指数( BMI)、 HAMD、HAMA、病程等混杂因素后,多因素线性回归分析结果显示,抑郁组 REM持续时间仍与 TBPM呈正相关[ β=0.017,95%CI:(0.003,0.031)];而 N2潜伏期与 TBPM的关联差异无统计学意义( P>0.05)。结论抑郁症病人存在睡眠结构异常和前瞻性记忆损害, TBPM与 REM持续时间呈正相关,且这种关联不受病人性别、年龄、文化、体质量指数、抑郁程度、焦虑程度和病程等的影响。 相似文献
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《Clinical neurophysiology》2009,120(7):1320-1328
ObjectiveThe use of functional near-infrared spectroscopy (fNIRS) is growing, leading to a need for methods to summarise data from multiple studies. However, this is difficult using the current channel-based methods when experiments do not share a common channel (CH) arrangement. Thus, we proposed and implemented a CH-independent analysis method for summarising fNIRS data.MethodsWe defined sub-regions as spatial bins to organise fNIRS data. Sub-regions were defined on the standard brain surface based on macro- and micro-structural information. After probabilistically estimating CH location in standard stereotaxic brain space, the CH-based data were reorganised into these spatial bins to evaluate sub-region-based activation.ResultsSub-regions with sizes corresponding to fNIRS spatial resolution were defined. We demonstrated this method by integrating data from two of our fNIRS studies that shared the same region of interest but used different channel arrangements.ConclusionsUsing this method, data from multiple fNIRS studies with different CH arrangements can be integrated in standard brain space, while keeping in mind the brain structure–function relationship.SignificanceThe current method will facilitate an effective use of accumulating fNIRS data by allowing integration of data from multiple studies. 相似文献
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目的 探讨精神分裂症病人的敌意归因偏向及其影响因素.方法 选取2018年8月至2019年8月合肥市第四人民医院住院精神分裂症病人90例为观察组,选取同期本医院所在社区精神正常者80例为健康对照组,采用中文版模棱两可、目的和敌意问卷(AIHQ-C)对两组作敌意归因偏向评估,同时作偏执量表(Pa)、多伦多述情障碍量表(TAS-20)、自动思维量表(ATQ)、威斯康星卡片分类(WCST)及阳性和阴性症状量表(PANSS)等评估,分析精神分裂症病人敌意归因偏向相关影响因素.结果 观察组的AIHQ-C、Pa[(17.02±4.99)分比(11.08±3.35)分]、TAS-20、ATQ[(65.32±23.03)分比(49.68±19.04)分]等各项评分显著高于健康对照组(P<0.01),观察组WCST的完成分类数显著低于健康对照组[(3.49±2.13)分比(5.44±1.21)分,P<0.01],持续性错误数显著高于健康对照组[(27.19±15.80)分比(14.45±8.37)分,P<0.01];Pearson相关分析显示:观察组的AI-HQ-C各项评分与Pa、TAS-20、ATQ评分、PANSS总分、阳性症状分及WCST的持续性错误数呈正相关(P<0.05或P<0.01).以AIHQ-C的责备偏向分为因变量多元回归提示,自变量中Pa评分与PANSS阳性症状分、WCST持续性错误数被纳入方程,标准化系数分别为0.260(P<0.05)、0.286(P<0.01)、0.257(P<0.01).结论 精神分裂症病人存在明显的敌意归因偏向及述情障碍,认知灵活性低,偏执、阳性症状及认知灵活性对病人的敌意归因偏向有预测作用. 相似文献
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BackgroundChildren with autism spectrum disorders (ASD) demonstrate distinctive scanning of faces, which has been suggested as an obstacle to social expertise, hindering their lifelong social relationships.MethodThis study aimed at comparing social attention in young children with and without ASD (N = 34). We designed two eye-tracking paired preference tasks to assess the effects of emotional expression and the actor’s gender (Experiment 1) and actor’s age (Experiment 2) on the visual scanning pattern of faces in both groups.ResultsData analysis yielded three behavioral markers in the ASD group: (1) late orientation to angry faces, (2) late orientation to child faces, and (3) superficial facial processing (shorter visits).ConclusionsClinical and research implications are discussed regarding potential markers that could contribute to early diagnosis and intervention. 相似文献
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Sun Jinmei Gao Xiaoran Hua Qiang Du Rongrong Liu Pingping Liu Tingting Yang Jinying Qiu Bensheng Ji Gong-Jun Hu Panpan Wang Kai 《Brain imaging and behavior》2022,16(2):565-573
Brain Imaging and Behavior - Cerebral specialization and inter-hemispheric cooperation are two of the most prominent functional architectures of the human brain. Their dysfunctions may be related... 相似文献