TORCH系列病原体感染与原发性高血压的相关性研究

目的：探讨TORCH系列病原体感染与原发性高血压的相关性研究。方法分别采集760例住院患者（年龄40～65岁）的血液,其中包括320例原发性高血压患者标本和440例对照标本,应用酶联免疫吸附试验（ELISA）检测血清TORCH系列病原体抗-IgG和抗-IgM,并进行两组间比较。结果高血压组患者人巨细胞病毒（HCMV）抗-IgG阳性率高于对照组（χ2=33.790,P=0.001）,单纯疱疹病毒（HSV）抗-IgG阳性率亦高于对照组（χ2=7.786,P =0.003）。结论 HCMV和HSV感染可能是原发性高血压的重要危险因素。     

针刺治疗儿童腹型偏头痛案

A girl patient, seven years old, complaining intermittent periumbilical pain accompanied with headache and vomiting for almost one year. Acupuncture was adopted in treatment. Acupoints were Băihuì(百会GV20), Yìntáng (印堂EX-HN3), Zhōngwăn (中脘CV12), Tàiyáng (太阳EX-HN5), Wángŭ (完骨GB12), Hégŭ (合谷LI4), Tiānshū (天枢ST25), Zúsānlĭ (足三里ST36), Sānyīnjiāo (三阴交SP6) and Tàichōng (太冲LR3), electroacupuncture, warming needling moxibustion and infrared irradiation were applied. Acupuncture and moxibustion were given once every two days and 10 treatments were as one course. After one course of treatment, the child patient narrated that the attack frequency of headache and abdominal pain was reduced, the severity alleviated and the persistent duration shortened. After two courses of treatment, abdominal pain never occurred and the child patient was recovered and had a normal life and school activity. The disease was not recurred in one-year follow-up.     

穴位埋线联合耳穴贴压治疗神经性贪食症18例

Prof. Min LI adopted acupoint catgut embedding at Zhōngwǎn (中脘CV12), Tiānshū (天枢ST25), Wèishū(胃俞BL21), Dàchángshū(大肠俞BL25), Zúsānlǐ (足三里ST36), Sányīnjiāo (三阴交SP6), and Tàichōng (太冲LR3), and combined with auricular plaster therapy at Wèi (胃 CO4) , Dà cháng (大肠 CO7) , Gān (肝CO12) ,Jiāogăn (交感 AH6a) ,Nèifēnmì (内分泌CO18) for the treatment of 18 cases of bulimia nervosa(BN). The result was that 9 cases were clinically cured, 6 cases improved, 3 case ineffective, and the total effective rate was 83.33%, no obvious adverse reactions. The therapeutic effect of acupoint catgut embedding combined with auricular plaster therapy for BN is good, without side effects.     

电针联合骨质疏松治疗仪对脊髓损伤患者骨代谢指标的影响

ObjectiveTo observe the effect of electroacupuncture combined with low-frequency pulsed electromagnetic field on bone metabolism in patients with spinal cord injury (SCI).MethodsThe 60 SCI patients who met the inclusion criteria were randomly divided into 2 groups by means of a random number table. In the control group, 30 patients were treated with osteoporosis treatment apparatus. In the observation group, 30 patients were treated with osteoporosis treatment apparatus and electroacupuncture at the foot-shaoyangacupoints [Yánglíngquán (阳陵泉GB 34) and Xuánzhōng (悬钟GB 39) of both sides].The treatment was applied once a day, 5 days a week, for 8 weeks.Before and after treatment, the changes of indexes in the two groups, including the bone mineral density (BMD), bone gla-containing protein (BGP), serum alkaline phosphatase (ALP), procollagen type I C-peptide (PICP), and 25‑hydroxy-vitamin D [25(OH)D], were observed for comparison.ResultsAfter treatment, in the two groups, the BMD and 25(OH)D indexes of the femoral neck, greater trochanter, and Ward's triangle region were not significantly changed in comparing with those before treatment (P>0.05), while the BGP, ALP, and PICP indexes were significantly higher than those before treatment (P<0.05). After treatment, in the observation group, the BGP and ALP indexes were significantly increased in comparing with those of the control group, and the difference was statistically significant (P<0.05), whilst the BMD, PICP, and 25(OH)D indexes of the femoral neck, greater trochanter, and wards triangle region, were not significantly different in comparing with the control group (P>0.05).ConclusionThe osteoporosis treatment apparatus can improve bone metabolism in SCI patients, and the curative effect can be enhanced when combined with electroacupuncture at foot-shaoyangacupoints.     

依据我国成人体重判定行业标准评价现行代谢综合征诊断标准在中老年人群中的应用

目的 :依据我国成人体重判定行业标准,评价现行代谢综合征(MS)3种诊断标准在合肥市中老年人群中的应用。方法:采用整群随机抽样方法,对合肥市某社区内40岁及以上常住居民进行问卷调查、体格检查和实验室检查。按照中华医学会糖尿病分会(CDS)诊断标准、国际糖尿病联盟(IDF)诊断标准和美国国家胆固醇教育计划成人治疗方案第3次报告(NCEP-ATPⅢ)分别计算MS的患病率,依据我国成人体重判定行业标准,修订现行CDS标准作为参考标准,评价上述3种标准及修订后的IDF和ATPⅢ在实际疾病筛查中的意义。结果:共调查2 860名居民,男1 093名(占38.22%),女1 767名(占61.78%),平均年龄(56.38±10.8)岁。按照CDS、IDF、ATPⅢ和参考标准,调查对象MS患病率分别为23.39%、34.55%、37.20%和26.71%,标化患病率分别为22.18%、33.73%、36.28%和25.33%。CDS与参考标准诊断时,男女间患病率无统计学差异,60~69岁年龄段MS患病率最高。IDF与ATPⅢ标准诊断时,50~59岁年龄段MS患病率最高,女性MS患病率高于男性。相同年龄段、相同性别人群均表现出CDS标准诊断MS患病率最低,ATPⅢ标准诊断MS患病率最高,差异有统计学意义。参照参考标准,现行CDS、IDF和ATPⅢ的灵敏度分别为87.57%、80.10%和84.29%,特异度分别为100.00%、82.06%和79.96%,阳性预测值分别为100.00%、61.94%和60.53%。修订后的IDF和ATPⅢ标准MS患病率分别为27.31%和32.76%,特异度分别为88.31%和84.40%,阳性预测值分别为68.63%和65.10%。结论:调查对象MS患病率较高,现行3种诊断标准中CDS标准诊断MS患病率最低,ATPⅢ标准诊断最高,参照成人体重判定修订现行标准,可提高CDS标准下MS患病率、IDF和ATPⅢ标准诊断的特异度和阳性预测值,在实际筛查工作中应结合调查对象的实际情况灵活选择诊断标准。     

血清TGAb、TPOAb在甲状腺疾病中的应用价值

目的探讨甲状腺球蛋白抗体(TGAb)和甲状腺过氧化物酶抗体(TPOAb)水平在甲状腺功能亢进(甲亢)和原发性甲状腺功能减退症(甲减)中的改变及其临床意义。方法将100例甲亢患者分成4组:甲亢初诊组、甲亢复发组、甲亢缓解组和治疗后转向甲减组。采用免疫化学发光法分别检测100例甲亢、60例原发性甲减患者和30例正常人的血清TGAb和TPOAb。结果甲亢组和原发性甲减组的TGAb和TPOAb阳性率与正常组比较差异均有统计学意义(P<0.01);100例甲亢患者治疗前后TPOAb阳性率明显高于TGAb的阳性率;无论是初诊组、复发组还是缓解组治疗前后两种抗体检测的阳性率比较,差异均有统计学意义(P<0.05)。结论 TGAb和TPOAb的定量检测在甲状腺疾病的鉴别、诊断及治疗中具有参考价值,TPOAb具有相对较高的临床价值。     

腹腔镜辅助胃癌根治术24例

目的探讨腹腔镜辅助胃癌根治术的效果。方法2009年1月～2011年12月,行腹腔镜辅助根治性胃切除术24例。腹腔镜下探查腹腔、清除大网膜及预定范围的淋巴结,通过上腹部小切口完成胃肿瘤切除和胃肠重建。结果中转开腹手术1例。余23例完成腹腔镜手术,其中根治性全胃切除术6例,近端胃大部切除术3例,远端胃大部切除术14例。手术时间全胃（171．0±32．5）min,近端胃130、185及210min,远端胃（137．2±40．2）min。术中出血量：全胃（260±80）ml,近端胃190、220、250ml,远端胃（190±50）ml。清除淋巴结（18．4±4．3）枚。术后排气时间（1．4±0．8）d。术后住院时间（12．0±3．4）d。术后随访12～24个月,平均16．3月。复发率21．7％（5／23）。结论腹腔镜胃癌根治术可行、可靠,能够达到与开腹手术相当的根治效果,且具有创伤小、术后恢复快等优点。     

大鼠肝缺血再灌注后高胆红素血症与Mrp2、Mrp3表达及定位改变的关系

目的 研究大鼠肝脏缺血再灌注后多耐药相关蛋白2(Mrp2)、多耐药相关蛋白3(Mrp3)表达及定位的改变,探讨肝缺血再灌注后发生高胆红素血症的分子机制.方法 实验分为假手术组(Sham组)和肝缺血30 min再灌注组(IR组).检测血浆和胆汁中DBIL含量.RT-PCR和免疫组织化学方法检测毛细胆管膜上Mrp2和基底膜...     

Correspondence Between Clinician Ratings of Vulvovaginal Health and Patient-Reported Sexual Function After Cancer

BackgroundTools for diagnosing sexual dysfunction and for tracking outcomes of interest include clinician interviews, physical exam, and patient self-report. Limited work has described relationships among these three sources of information regarding female sexual dysfunction and vulvovaginal health.AimWe describe correlations among data collected from clinician interviews, clinical gynecological examination, and patient self-report.MethodsData are from a single-site, single-arm, prospective trial in 100 postmenopausal patients with a history of breast or endometrial cancer who sought treatment for vulvovaginal symptoms. The trial collected a standardized clinical gynecologic exam, clinician-reported outcome (ClinRO) measures of vulvovaginal dryness and pain, and patient-reported outcome (PRO) measures of sexual function, including PROMIS Sexual Function and Satisfaction (SexFS) lubrication, vaginal discomfort, labial discomfort, and clitoral discomfort and Female Sexual Function Index (FSFI) lubrication and pain. We examined polyserial correlations between measures with bootstrapped 95% confidence intervals from the baseline and 12–14-week timepoints.ResultsAll of the relationships between the ClinRO variables and the PRO variables were in the expected direction (ie, positive), but the strength of the relationships varied substantially. At 12–14 weeks, there were medium-to-large correlations between ClinRO vaginal dryness and SexFS Lubrication (0.64), ClinRO vulvar dryness and SexFS Lubrication (0.46), ClinRO vulvar discomfort and SexFS Labial Discomfort (0.70), and ClinRO vulvar discomfort and SexFS Clitoral Discomfort (0.43). With one exception, the correlations between the exam variables and the corresponding PRO scores were small (range 0.01–0.27).Strengths & LimitationsOur study included a comprehensive, standardized gynecologic exam designed specifically to evaluate sexual dysfunction as well as established PRO measures with significant evidence for validity. A limitation of our findings is that the sample size was relatively small, and our sample was restricted to women who received cancer treatments known to have dramatic effects on vulvovaginal tissue quality.ConclusionPatient- and clinician-reported vulvovaginal dryness and discomfort were moderately correlated with each other but not with clinical gynecologic exam findings. Understanding the relationships among these different types of data highlights the distinct contributions of each to understand vulvovaginal tissue quality and patient sexual function after cancer. Flynn KE, Lin L, Carter J, et al. Correspondence Between Clinician Ratings of Vulvovaginal Health and Patient-Reported Sexual Function After Cancer. J Sex Med 2021;18:1768–1774.