婴幼儿轮状病毒性腹泻检测结果分析

目的了解唐山市婴幼儿腹泻患者轮状病毒(HRV)的感染情况,为临床治疗和预防提供科学依据。方法收集2007年4月-2009年3月腹泻病患儿粪便标本2413份,采用胶体金法检测轮状病毒。结果 2413份标本中,阳性率为25.20%,其中<2岁患儿占87.66%;男性标本共1362例,阳性率38.11%;女性标本1051例,阳性率37.16%。结论 HRV是唐山地区儿童腹泻病的主要病原体,<2岁儿童是HRV感染腹泻的易感人群,应注意防范。     

呋塞米治疗产前妊娠高血压性心衰疗效观察

目的:观察呋塞米治疗产前妊娠高血压性心衰患者疗效。方法:将110例产前妊娠高血压性心衰患者随机分为呋塞米治疗组(治疗组)和常规治疗组(对照组),观察两组患者西地兰用量、心衰缓解时间、硝酸甘油的平均速度、治疗前后血压平均下降范围及治疗组用药前后血清钾的变化。结果:治疗组呋塞米平均用量60 mg。西地兰平均用量治疗组0.6 mg,对照组1.4 mg;心衰缓解时间治疗组3.8 h,对照组6.6 h,两组比较差异有统计学意义(P<0.01)。硝酸甘油的平均速度治疗组40μg/min,对照组60μg/min,两组比较差异有统计学意义(P<0.01)。治疗组治疗后收缩压平均下降42.12 mmHg,舒张压平均下降25.33 mmHg;对照组治疗后收缩压平均下降38.62 mmHg,舒张压平均下降23.51 mmHg,两组比较差异有统计学意义(P<0.01)。治疗组治疗前后血清钾平均值分别是3.66 mmol/L、3.37 mmol/L,治疗前后差异无统计学意义(P>0.05)。结论:产前妊娠高血压性心衰在强心、降压的基础上静注呋塞米能够较快的控制心衰,减少西地兰、硝酸甘油的用量,同时又可控制血压,血清钾下降不明显,是一种安全、可靠的治疗产前妊娠高血压性心衰理想药物之一。     

超声测量胎儿相关径线与预测分娩方式分析

目的用超声测量胎儿的相关径线,探讨预测分娩方式。方法对190例孕妇产前1周超声测量双顶径/胸围、腹围/双顶径、骨盆入口前后径-双顶径之差的相关数据,协助孕妇预定分娩方式,减少盲目试产和降低剖宫产率。结果超声估计胎儿体重4 000 g以下,骶耻径与双顶径差≥23 mm,可拟诊阴道产;超声估计胎儿体重4 000 g以上,胸围与头围差≥16 mm,腹径与双顶径差≥26 mm,可拟诊剖宫产。结论采用超声测量胎儿双顶、头围、胸围、腹围等数值来预测胎儿分娩途径有良好的预测性。     

The polymorphism of EGFR 142285G > A exerts no risk effect on breast cancer

The association between the epidermal growth factor receptor (EGFR) 142285G?>?A polymorphism and the susceptibility to breast cancer is unclear. We conducted a meta-analysis of all published studies to estimate the association of EGFR 142285G?>?A polymorphism and breast cancer risk. Systematic computerized searching of the PubMed, Web of Science, and Wanfang databases was performed for relevant publications. Overall, there were three eligible case–control studies with 1,360 cases and 1,522 controls included into our study. The pooled ORs showed that the EGFR 142285G?>?A variant genotypes did not increase or decrease the risk of breast cancer under the following gene models: A vs. G, OR?=?1.07, 95 % CI 0.96–1.19, P _OR?=?0.240; AA vs. GG, OR?=?1.14, 95 % CI 0.91–1.42, P _OR?=?0.239; GA vs. GG, OR?=?0.99, 95 % CI 0.83–1.17, P _OR?=?0.892; GA?+?AA vs. GG, OR?=?1.03, 95 % CI 0.87–1.21, P _OR?=?0.727; AA vs. GG?+?GA, OR?=?1.17, 95 % CI 0.97–1.42, P _OR?=?0.096. The between-study heterogeneity was not significant among all studies. The current meta-analysis showed no evidence for significant association between EGFR 142285G?>?A polymorphism and breast cancer risk. Subsequent studies with large sample size are needed for further elucidation.     

负压型子宫内膜取样器与分段诊刮术对子宫内膜癌患者宫颈受累的诊断价值

目的探讨负压型子宫内膜取样器与分段诊刮术对子宫内膜癌患者宫颈受累的诊断价值。方法采用随机数字表法将接受手术治疗的88例子宫内膜癌患者分为对照组和观察组,每组44例。对照组患者采用分段诊刮术,观察组患者采用负压型子宫内膜取样器,比较两种方法对宫颈受累的诊断效能、子宫内膜组织取样出血量、视觉模拟评分法(VAS)评分、样本质量及取样满意度。结果以术后病理诊断结果为金标准,采用负压型子宫内膜取样器诊断宫颈受累的灵敏度、特异度、阳性预测值、阴性预测值、约登指数、诊断符合率均高于分段诊刮术,差异均有统计学意义(P﹤0.05),误诊率、漏诊率均低于分段诊刮术,差异均有统计学意义(P﹤0.05)。观察组患者子宫内膜组织取样出血量明显少于对照组,差异有统计学意义(P﹤0.01);观察组患者的VAS评分明显低于对照组,差异有统计学意义(P﹤0.01);两组患者的样本质量比较,差异无统计学意义(P﹥0.05)。观察组患者的取样满意度为90.91%,高于对照组的79.55%,差异有统计学意义(P﹤0.05)。结论负压型子宫内膜取样器对子宫内膜癌患者宫颈受累具有较高的诊断效能,且能够有效降低患者的子宫出血量和疼痛程度,提高患者满意度。     

妊娠期高血压综合征患者甲胎蛋白水平及其对围生儿预后的影响

目的探讨妊娠期高血压综合征(PIH)患者血清甲胎蛋白(AFP)水平及其对围生儿预后的影响,为临床预测PIH及围生儿预后提供依据。方法采用放射免疫法测定118例PIH孕妇(PIH组)和160例正常孕妇(对照组)的血清AFP水平,并随访至分娩,分析PIH患者血清AFP水平与妊娠结局及围生儿预后的相关性。结果 PIH组血清AFP水平为(209.88±34.18)μg/L明显高于对照组的(177.58±32.67)μg/L,差异有统计学意义(P<0.05);重度亚组血清AFP水平高于轻度、中度亚组孕妇及对照组,差异均有统计学意义(P<0.05)。PIH组中AFP水平≥250μg/L足月小样儿发生率、孕妇新生儿出生1min Apgar评分≤7分者百分率及围生儿病死率均高于<250μg/L者,差异均有统计学意义(P<0.05)。结论孕妇血清AFP水平可作为判断PIH病情轻重及判断围生儿预后的指标。     

Effect of body mass index trajectory on lifetime risk of cardiovascular disease in a Chinese population: A cohort study

Background and aimsThe longitudinal trajectories of body mass index (BMI) can reflect the pattern of BMI changes. Lifetime risk quantifies the cumulative risk of developing a disease over the remaining life of a person. We aimed to identify the trajectory of BMI and explore its association with cardiovascular disease (CVD) in the Chinese population.Methods and resultsA total of 68,603 participants with a mean age of 55.46 years were included from the Kailuan cohort in Tangshan, China, who were free of CVD and cancer and with repeated measurements of BMI from 2006 to 2010. A latent mixture model was used to identify BMI trajectories. An improved Kaplan-Meier estimator was used to predict the lifetime risk of CVD according to BMI trajectories. During a median follow-up of 7.0 years, 3325 participants developed CVD. Five BMI trajectories were identified at three index ages (35, 45, and 55) respectively. For index age 35 years, compared with the stable low-normal weight group (22.7% [95% CI, 20.0%–25.4%]), the stable high-normal weight (27.6% [25.6%–29.5%]), stable overweight (29.4% [27.4%–31.4%]), stable-low obesity (32.8% [30.0%–35.5%]), and stable-high obesity (38.9% [33.3%–44.5%]) groups had a higher lifetime risk of CVD (P < 0.05). We observed similar patterns for stroke and myocardial infarction. Similarly, the lifetime risk of CVD was higher in the long-term overweight and obese groups at 45 and 55 index ages.ConclusionsLong-term overweight and obesity were associated with an increased lifetime risk of CVD. Our findings could assist in predicting the population burden of CVD.     

健脾补肾、益气祛浊法治疗糖尿病肾病Ⅲ期的疗效观察及对免疫功能的影响

[目的]观察健脾补肾、益气祛浊法治疗糖尿病肾病Ⅲ期患者的临床疗效及对免疫功能的影响.[方法]选择糖尿病肾病Ⅲ期患者,随机分为对照组和治疗组,两组均接受常规治疗及护理.对照组口服缬沙坦胶囊,80 mg/次,每日1次.治疗组在对照组的基础上加用中药汤剂口服.疗程8周,治疗前后进行疗效性观察指标、肾功能损害相关指标、免疫功能...     

影响无痛瘢痕子宫阴道试分娩结局的危险因素分析

目的 分析影响无痛瘢痕子宫阴道试分娩结局的危险因素.方法 选取2017年6月至2018年6月河北省唐山市妇幼保健院收治的238例瘢痕子宫阴道试分娩产妇作为研究对象,进行回顾性分析.根据阴道试分娩结局分为成功组(n=147)和失败组(n=91).采用Logistic回归分析探究产妇临床资料对发生不良妊娠结局的影响.结果 ...