小型钛板坚固内固定术对下颌骨骨折疗效观察

目的 分析下颌骨骨折应用小型钛板坚固内固定术治疗的效果。方法 本组32例下颌骨骨折患者,均伴有咬【牙合】关系紊乱,采用小型钛板行骨折坚固内固定术,分别于术后1、3、6个月拍摄X线片复查,以临床伤口愈合、胎关系、张口度及骨折线愈合情况作为评价指标判断疗效。结果 32例中32例手术切口甲级愈合（100％）,临床检查开口度在35mm以上,咬【牙合】关系良好,X线片示骨折线对位愈合良好,部分病例3个月时骨折线不可见。结论 应用小型钛板坚同内固定术治疗下颌骨骨折疗效可靠,方法简单,值得临床常规推广。     

Patterns of lingual split and lateral bone cut end and their associations with neurosensory disturbance after bilateral sagittal split osteotomy

The purpose of this study was to characterize the patterns of lingual split and lateral bone cut end (LBCE) after bilateral sagittal split osteotomy (BSSO) in patients and identify their associations with postoperative neurosensory disturbance. This retrospective cohort study recruited 273 patients with skeletal malocclusion who received BSSO. The postoperative cone beam computed tomography data were reconstructed to three-dimensionally view the patterns of lingual split and LBCE. Associations between lingual split and LBCE and their effects on neurosensory disturbance in the lower lip and chin were determined. Six types of lingual split and three types of LBCE were defined based on three-dimensional images. Type I lingual split as a vertical fracture line to the inferior mandibular border was the most common (40.29%). Inferior LBCE was the most prevalent, followed by lingual and buccal types. Significant associations among lingual split, LBCE and skeletal deformities were found (P < 0.05). However, patterns of lingual split and LBCE were not associated with the incidence of neurosensory disturbance. Patterns of lingual split after BSSO significantly associated with types of LBCE and dentomaxillofacial deformities, but not with postoperative neurosensory disturbance.     

Predictive factors in the treatment of oral squamous cell carcinoma using PD-1/PD-L1 inhibitors

Investigational New Drugs - Due to immune impairment and lymphocyte enrichment of oral squamous cell carcinoma (OSCC), anti-PD-1/PD-L1 therapy is regarded as a potential treatment option. However,...     

双酸酸蚀钛表面复合含钙纳米薄片膜层对成骨细胞行为的影响

目的：制备含钙纳米薄片膜层修饰的双酸酸蚀钛表面并评价其对成骨细胞行为的影响。方法：通过双酸酸蚀和氢氧化钙/双氧水混合溶液水热处理,制备2种含钙纳米薄片膜层修饰的双酸酸蚀钛表面（1 h、6 h处理组）。以大颗粒喷砂酸蚀（SLA）钛表面为对照组,2种含钙纳米薄片膜层修饰的双酸酸蚀钛表面为实验组,观察分析不同钛表面的微形貌和表面元素组成;将MC3T3-E1成骨细胞接种于各组试件表面,研究不同钛表面对成骨细胞生物学行为的影响。结果：在双酸酸蚀钛表面制备形成2种形貌均一的纳米薄片膜层结构,均含有微量钙元素。相比于SLA钛表面,2种新型钛表面均有利于MC3T3-E1成骨细胞的黏附和增殖,显著增强成骨细胞的碱性磷酸酶活性,并上调成骨相关基因的表达。其中,1 h处理组性能更优。结论：双酸酸蚀钛表面复合含钙纳米薄片膜层能有效促进成骨细胞的黏附、增殖和分化。     

牙种植术中钻孔提拉方式及冷却系统对术区温度的影响

目的: 研究牙种植术中不同钻孔提拉方式及不同冷却系统对术区牙槽骨温度的影响, 探讨牙种植术中温度场的变化。方法: 制作48个统一标准的模拟骨块, 根据不同钻孔提拉方式和不同冷却系统分为6组, 每组8个骨块, 进行温度场试验, 测定不同骨块中温度场的温度最高值。采用SPSS12.0软件包对数据进行单因素方差分析。结果: 在相同的钻孔提拉方式下, 内冷却系统温度控制方式术区温度低于外冷却系统的温度控制方式;在相同的冷却系统下, 2次钻孔提拉方式术区温度低于直接1次钻孔方式。其中, 采用内冷却系统进行温度控制时, 2次钻孔提拉方式的术区温度最低(P<0.05)。结论: 牙种植术中采用多次钻孔提拉方式及内冷却系统的温度控制方式, 可以有效降低术区温度, 减少手术产热, 提高牙种植术成功率。     

前牙美学区种植义齿个体化修复及临床评价

目的:针对前牙美学区牙列缺损且修复条件异常的患者,选取不同修复方案进行个体化修复并评价其临床效果。方法:依据纳入标准,选取接受种植修复治疗并完成前牙美学区个体化修复的患者46例、共58颗种植修复体作为研究对象,随访3～24个月,观察临床效果并利用前牙区红白美学指标给予评分。结果:研究对象年龄18～69岁,平均随访期12.6个月。所有植体均获得良好骨结合,未见植体失败或种植体周围炎病例。依据红白美学标准评估3个月时种植修复体,红色美学低分段者占1.72%,中分段者占44.83%,高分段者占53.45%;白色美学低分段者占0%,中分段者占20.69%,高分段者占79.31%。结论:前牙美学区个体化修复方案可有效改善缺牙患者的外观,及时复诊随访和口腔卫生维护有利于避免种植体及修复体并发症,长期效果有待观察。     

数字医学辅助下创伤性骨化肌炎的手术治疗：1例报告及文献复习

PURPOSE : To evaluate the short-term effect of individualized template guided 125I seed implants for advanced unresectable malignant salivary gland tumors, and explore its superiority. METHODS : Fourteen patients with histologically documented advanced unresectable malignant salivary gland tumors were treated by radioactive 125I seeds interstitial implantation under the aid of individualized template guide. The treatment response, distribution of seeds, local control rate and survival rate were evaluated and the adverse events observed. RUSULTS: The actuarial median number of 125I seeds treated was 43, and actuarial median D90,V100,V150 was 186.2 Gy, 98.2%, 43.4%, respectively; The average radiation dose received by the eyes and brain was 3.2 Gy, 32.5 Gy, respectively; The overall response rate was 78.3%. The patients were followed up for 15 to 28 months (median 23 months). The local control rate was 78.6%, and overall survival rate was 78.6%. No serious side radiotherapeutic effect was observed. CONCLUSION S: The method of individualized template-guided 125I seed implants for advanced unresectable malignant salivary gland tumors is feasible, minimally invasive, safe and easy to operate, which can be widely used in clinical practice.     

镍钛机用系统在根管预备中的应用（综述）

根管预备是根管治疗的关键步骤。机用镍钛系统具有切削效率较高、减少根尖偏移、形成锥形根管不易将根管预备碎屑推出根尖孔等优点。本文就目前常用的镍钛机用系统的性能作一综述。