不同强度经皮穴位电刺激对胸腔镜手术患者术后免疫功能的影响

目的观察不同强度经皮穴位电刺激(TEAS)对胸腔镜手术患者术后免疫功能的影响。方法将68例行胸腔镜手术治疗的患者按住院先后顺序采取随机数字表法分为低强度TEAS组、中强度TEAS组、高强度TEAS组和电针组,每组17例。4组术后在镇痛泵治疗的基础上,给予不同强度的TEAS或电针治疗。观察4组患者治疗前后T淋巴细胞亚群、自然杀伤细胞(NK细胞)和血清免疫球蛋白水平。结果4组术后CD3﹢和CD4﹢T淋巴细胞、NK细胞、血清IgM、血清IgG的水平均较术前降低(P<0.05);术后48 h低强度TEAS组和高强度TEAS组的CD3﹢和CD4﹢T淋巴细胞、NK细胞、血清IgM的水平均低于电针组(P<0.05);中强度TEAS组和电针组比较差异无统计学意义(P>0.05)。4组术后CD8﹢T淋巴细胞、CD4﹢/CD8﹢以及血清IgG水平组间比较,差异无统计学意义(P>0.05)。结论中强度TEAS能够有效改善胸腔镜手术后患者的免疫功能。     

Can dogs serve as stress mediators to decrease salivary cortisol levels in a population of liberal arts college undergraduate students?

The steroid hormone cortisol can be used to measure physiological stress in humans. The hypothalamic-pituitary-adrenal (HPA) axis synthesizes cortisol, and a negative feedback cycle regulates cortisol depending on an individual's stress level and/or circadian rhythm. Chronic stress of college undergraduate students is associated with various adverse health effects, including anxiety and depression. Reports suggest that stress levels have risen dramatically in recent years, particularly among university students dealing with intense academic loads in addition to COVID-19 pandemic-related uncertainty. The increasing rate of mental illness on college campuses necessitates the study of mediators potentially capable of lowering stress, and thus cortisol levels. Research on mediation techniques and coping mechanisms have gained traction to address the concerning levels of stress, including the employment of human-animal interaction sessions on college campuses. In this study, human-canine interaction as a stress mediation strategy for undergraduate students was investigated. We measured salivary cortisol levels in 73 college undergraduate students during a 60-min interaction period with a dog to determine whether human-canine interactions are effective in lowering cortisol levels and potentially reducing chronic stress typical of undergraduate students. Our results indicate that a human-canine interaction for 60 min is an effective method for significantly reducing salivary cortisol and stress levels among undergraduate college students. These findings support the expansion of animal visitation programs on college campuses to help students manage stress.     

2,2-双取代-4,6-二氨基-1,2-二氢-1-羟基-s-三嗪类化合物的合成研究

目的 对三嗪类化合物进行合成研究。方法 以盐酸羟胺和苯甲酰氯为原料，经酰化、烃化、水解、缩合、环合及脱苄反应合成目的物。结果和结论 共合成了9个2，2-双取代-4，6-二氨基-l，2-二氢-l-羟基-s-三嗪类化合物(11-i)，结构经元素分析、红外吸收光谱、核磁共振氢谱及质谱确证。     

EFFECT OF ELECTROACUPUNCTURE OF SCALP-POINTS ON ABNORMAL DISCHARGES OF NEURONSAROUND THE CEREBRAL HEMORRHAGE FOCUS IN THE RAT

Thereexistdifferentdegreesofpathophysi ologicchangesinthetissuesaroundhemorrhagefocusafteracutecerebralhemorrhage[1 ] .Cere bralhemorrhageoftenleadstodysfunctionoftheneuronsinthebrain ,manifestingabnormalelec tricalactivity .Followingacutecerebralhemor rhage,duetotheoppressionofthehematomaandthetoxiceffectofthebloodcontentsaswellaschangesofthemicro environmentaroundthehemorrhagefocus,theelectricalactivityofthecerebralneuronsissuppressedatdifferentde grees.Electroacupuncture (EA)therapyworkell…     

Kneading manipulation

In the performance of rubbing manipulation, because of the fingers comparatively light vertical pressure and large-range circular movement, the palm and fingers cannot adhere to the patient's skin, and the relative friction movement.     

不同粒径的水飞蓟素固体脂质纳米粒口服吸收比较研究

目的:考察不同粒径的固体脂质纳米粒对大鼠口服吸收水飞蓟素的影响。方法:以山榆酸甘油酯为载体材料,分别制备了150,500,1 000 nm 3种粒径的水飞蓟素固体脂质纳米粒,给大鼠灌胃后,采用RP-HPLC测定不同时间点血药浓度,数据经3p97软件进行处理。结果:口服150 nm水飞蓟素固体脂质纳米粒后的AUC分别是500,1 000 nm的2.08,2.54倍(P<0.05),这表明150 nm固体脂质纳米粒的生物利用度明显高于其他2种制剂。结论:固体脂质纳米粒粒径对水飞蓟素的口服吸收有着显著影响。     

间歇性外斜视的手术治疗

目的探讨间歇性外斜视手术治疗的疗效。方法回顾性分析30例间歇性外斜视患者的术前情况、手术情况及术后1～4周的随访情况,根据斜视的类型选择不同的手术方式并评价其治疗效果。结果30例间歇性外斜视患者术后临床治愈26例,占86．7%；欠矫4例,占13．3%。结论局麻手术时手术量的设计不应该因患者紧张而减小；正确选择间歇性外斜视的手术时机,发现双眼单视功能丧失或部分丧失时,应尽早手术矫正,可有利于双眼视功能的建立。     

归苓片改善动物学习记忆功能的研究

目的研究归苓片(FBD)促进动物学习记忆功能的作用。方法小鼠ig给予35、70、140mg/kg FBD,连续1周,观察FBD对东莨菪碱所致小鼠记忆获得障碍、亚硝酸钠所致小鼠记忆巩固不良和45%乙醇致小鼠记忆再现障碍的影响,并观察FBD对大鼠双侧颈总动脉结扎所致的慢性脑部供血不足而产生的记忆障碍的改善作用。结果FBD对由东莨菪碱所致的小鼠记忆获得障碍、亚硝酸钠所致的小鼠记忆巩固不良和45%乙醇所致的小鼠记忆再现障碍均有明显的改善作用;并可改善大鼠双侧颈总动脉结扎所致的慢性脑部供血不足而产生的记忆障碍。结论FBD可促进动物的学习记忆功能。     

电针对大鼠不稳定膀胱逼尿肌及膀胱颈氮能神经递质的影响

目的:观察电针治疗对大鼠不稳定膀胱模型下尿路组织氮能神经递质的影响。方法:制作大鼠不稳定膀胱模型,电针会阳、中膂俞7d后,采用免疫组织化学法检测大鼠膀胱逼尿肌、膀胱颈平滑肌神经源性一氧化氮合酶(neuronal nitric oxide synthase,nNOS)、内皮型一氧化氮合酶(endothelial nitric oxide syn-thase,eNOS)和诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)阳性细胞并计数。结果:不稳定膀胱模型其膀胱逼尿肌、膀胱颈平滑肌中氮能神经递质明显下降,而电针治疗则可促进氮能神经递质的生成和分泌。结论:电针促进膀胱组织中氮能神经递质的生成和分泌可能是电针治疗改善不稳定膀胱功能的主要机制之一。     

Clinical observations on electroacupuncture treatment of unstable bladder

目的:对电针治疗不稳定膀胱进行临床疗效评价.方法:将患者随机分为电针组和对照组,根据治疗前后临床症状积分和生活质量评分的改善情况进行疗效评价.结果:观察指标两组治疗后均较治疗前显著降低(P＜0.05),两组间比较临床症状积分无显著性差异(P＞0.05);生活质量评分电针组较手法组下降明显(P＜0.05).结论:两种治疗方法对不稳定膀胱均有改善,其中电针组生活质量满意度要优于手法组,临床症状积分有低于手法组的趋势.