Study on the inflammatory response in the contralateral eye after phacoemulsification combined with intraocular lens implantation in the first eye

AIM: To explore whether there is an inflammatory response in the contralateral eye after cataract surgery in the first eye, and try to explore the development of the inflammatory response. METHODS: In this paired-sample study, aqueous humor samples from 37 bilateral age-related cataract patients were collected just before each cataract surgery. Samples collected during the first-eye cataract surgery were marked as Group A, samples collected during the second-eye cataract surgery were marked as Group B. In addition, the samples were classified into five groups according to different operation intervals between the first and the second cataract surgery. Finally, the concentration of 13 selected cytokines (including TNF-α, IL-6, IL-8, CCL2/MCP-1, IL-6 Rα, IL-1 ra, MIP-1α, MIP-1d, CCL4, IL-2, CXCL9, TIMP-1, CCL11) in aqueous humor samples was detected by Luminex-200 (RnD) simultaneously in accordance with the manufacturer’s instructions. RESULTS: Among the 13 selected cytokines, there was statistically difference between the first and the second eyes in concentration of IL-6, MIP-1α, CCL2/MCP-1, TNF-α, MIP-1d, IL-2 and TIMP-1 (P<0.05), and the expression levels of all these seven cytokines in the second eyes were higher than those in the first eyes, and the concentration of IL-6 and MIP-1a in the second eyes was significantly higher than that in the first eyes (P<0.001). Compared with the first eyes, the concentration of CCL4, CCL11, IL-6Rα, CXCL9, and IL-1ra in the second eyes only showed slightly increase, while IL-8 showed a slight decrease, all with no statistically difference (all P>0.05). The concentration differences of IL-6, MCP-1/CCL2, IL-2, MIP-1d between the first eyes and the second eyes were most obvious at the third week after phacoemulsification combined with intraocular lens implantation (PHACO+IOL) in the first eye. CONCLUSION: This study revealed that there may be an inflammatory response in the contralateral eye after cataract surgery in the first eye, and the inflammatory response in the second eye appears to be most significant at the third week after phacoemulsification combined with intraocular lens implantation (PHACO+IOL) in the first eye.     

核仁素与肿瘤生物学行为的关系

核仁素的异常表达存在于多种疾病进展中,特别会影响炎症反应、病毒感染、肿瘤等疾病的发生和进展.核仁素在多种肿瘤中表达量升高,分布位置发生变化,影响肿瘤细胞增殖、凋亡、肿瘤转移等多个过程.     

塔系统安全阀若干典型工况的分析和探讨

塔系统作为一个较为复杂的系统,在安全阀工况分析时,会遇到一些较复杂的工况。对某塔系统安全阀的若干典型工况进行了分析与探讨,对一些常见塔系统安全阀的工况分析具有一定的指导和参考作用。     

内源性一氧化氮合酶抑制剂与重编程功能性心肌干细胞

干细胞再生医学在器官组织修复中已凸现出非常重要的地位。通过外源性表达基因进行体细胞的重编程,是目前最有希望获得供移植细胞的方式。微环境对于移植细胞的存活、迁移、分化起决定性作用。内源性一氧化氮合酶抑制剂系统（ADMA/DDAH）不但在调控血管生成中起着关键性作用,而且对肌细胞的诱导分化和促进肌生成方面发挥重要作用。本文就ADMA/DDAH对重编程＂功能性心肌细胞＂的作用予以阐述。     

Brain-derived neurotrophic factor inhibits glucose intolerance after cerebral ischemia

Brain-derived neurotrophic factor is associated with the insulin signaling pathway and glucose tabolism. We hypothesized that expression of brain-derived neurotrophic factor and its receptor may be involved in glucose intolerance following ischemic stress. To verify this hypothesis, this study aimed to observe the changes in brain-derived neurotrophic factor and tyrosine kinase B receptor expression in glucose metabolism-associated regions following cerebral ischemic stress in mice. At day 1 after middle cerebral artery occlusion, the expression levels of brain-derived neurotrophic factor were significantly decreased in the ischemic cortex, hypothalamus, liver, skeletal muscle, and pancreas. The expression levels of tyrosine kinase B receptor were decreased in the hypothalamus and liver, and increased in the skeletal muscle and pancreas, but remained unchanged in the cortex. Intrahypothalamic administration of brain-derived neurotrophic factor (40 ng) suppressed the decrease in insulin receptor and tyrosine-phosphorylated insulin receptor expression in the liver and skeletal muscle, and inhibited the overexpression of gluconeogenesis-associated phosphoenolpyruvate carboxykinase and glucose-6-phosphatase in the liver of cerebral ischemic mice. However, serum insulin levels remained unchanged. Our experimental findings indicate that brain-derived neurotrophic factor can promote glucose metabolism, reduce gluconeogenesis, and decrease blood glucose levels after cerebral ischemic stress. The low expression of brain-derived neurotrophic factor following cerebral ischemia may be involved in the development of glucose intolerance.     

糖尿病患者白内障与老年性白内障手术疗效对比分析

目的通过比较糖尿病患者白内障与老年性白内障超声乳化联合人工晶状体植入术后状况,探讨糖尿病患者白内障超声乳化联合人工晶状体植入术的疗效。方法对224例（252只眼）糖尿病患者和232例（267只眼）老年性白内障患者的超声乳化联合人工晶状体植入术后疗效进行统计学分析比较。结果两组患者术后视力比较差异无统计学意义（P〉0.05）,两组的术后并发症的发生率差异有统计学意义（P〈0.05）。结论对于于糖尿病患者,只要术前经过适当饮食控制或加用适量降糖药物,使血糖稳定在一定水平而无全身或眼部严重并发症者,施行PHACO联合IOL植入术是安全可靠的,对增生性视网膜病变的糖尿病患者,应慎重考虑手术治疗。     

某社区老年人毛细血管血脂与静脉血脂的相关性分析

[目的]研究社区老年人毛细血管血脂与静脉血脂检测结果的差别及相关性,探讨毛细血管血脂检测的可靠性。[方法]用便携式全血检测仪测定毛细血管血脂408例,同时用全自动生化分析仪测静脉血脂。[结果]毛细血管检测总胆固醇值(TC)高于静脉值(t=10.13,P<0.001),毛细血管检测三酰甘油(TG)低于静脉值(t=11.96,P<0.001);两种检测方法所测得的TC、TG存在正相关性关系且相关较密切(r2分别为0.625和0.705)。[结论]应用便携式全血检测仪测毛细血管血脂具有快速、简便和易于被老年人接受的特点,可以替代静脉法血脂监测。     

低碳经济时代空调系统设计改进意见

主要通过对甲、乙类生产厂房空调通风系统、危险品库的空调通风系统、实验动物房空调通风系统的设计改进，来阐述空调行业如何在低碳经济时代有新的节能突破口。     

可燃气体和有毒气体检测报警系统的合理应用

可燃气体和有毒气体检测基于完全不同的原理,其标定方法也有所不同。能够合理应用可燃气体和有毒气体检测报警系统的关键主要有三个方面：一是检测方法的正确选用;二是报警系统的正确配置;三是检（探）测器的合理布置和正确安装。