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81.
《BONE》2015
IntroductionPeriodontitis and osteoporosis are bone destructive diseases with a high prevalence in the adult population. The concomitant presence of osteoporosis may be a risk factor of progression of periodontal destruction. We studied the effect of sclerostin-neutralizing monoclonal antibody (Scl-Ab) on alveolar bone endpoints in an ovariectomized (OVX) rat model of induced experimental periodontitis.MethodsSixty female, 4-month-old Sprague–Dawley rats underwent sham operation or bilateral OVX and were left untreated for 2 months. Experimental periodontitis (ligature) was established by placing silk sutures subgingival to the right maxillary first and second molar teeth for 4 weeks, and feeding the rats food and high-sugar drinking water during this period. Thereafter, ligatures were removed and 25 mg/kg vehicle or Scl-Ab was administered subcutaneously twice weekly for 6 weeks. Rats were randomized into four groups: (1) Control (Sham + Vehicle), (2) Sham + Ligature + Vehicle, (3) OVX + Ligature + Vehicle, and (4) OVX + Ligature + Scl-Ab. Terminal blood and right maxilla specimens were collected for analyses.ResultsGroup 3 rats showed lower bone volume fraction (BVF) of alveolar bone with higher bone resorption and lower bone formation than Group 2 rats. Group 4 rats had higher alveolar crest height, as assessed by linear distance of cementoenamel junction to the alveolar bone crest and greater alveolar bone mass using Micro CT, than Group 3 rats. Significantly higher values of mineral apposition rate (MAR) and mineralizing surface/bone surface (MS/BS) were also observed in Group 4 rats by analyzing polychrome sequential labeling data. Increased serum osteocalcin and osteoprotegerin, and deceased serum tartrate-resistant acid phosphatase and CTx-1 illustrate the ability of Scl-Ab to increase alveolar bone mass by enhancing bone formation and decreasing bone resorption in an animal model of estrogen deficiency osteopenia plus periodontitis.ConclusionScl-Ab could be a potential bone anabolic agent for improving alveolar crest height and higher alveolar bone mass in conditions where alveolar bone loss in periodontitis is compounded by estrogen deficiency osteopenia. 相似文献
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Hong-Shi Li Jie Ke Gui-Zhi Zhao Li-An Wu Jun-Ping Kou Hong-Chen Liu 《中华医学杂志(英文版)》2015,128(14):1948-1955
Background:The pain caused by orthodontic treatment has been considered as tough problems in orthodontic practice.There is substantial literature on pain which has exactly effected on learning and memo... 相似文献
83.
Helicobacter pylori specific immune response induced by conservative flagellin linear B-cell epitope
Ji WS Hu JL Wu KC Qiu JW Han ZY Ding J Fan DM 《World journal of gastroenterology : WJG》2005,11(23):3528-3532
AIM:To testify the immunogenicity of a conservative B-cell linear epitope of Helicobacter pylori (H pylori) flagellin A. METHODS: Different programs were used to analyze the secondary structure, molecular hydropathy, and surface accessibility of H pylori flagellin A. Linear B-cell epitopes were estimated based on the structural and physiochemical information. Analysis of residue divergence was proposed to screen a conservative linear epitope. The 29-peptide (Pep29mer) synthesized by chemical method, including the predicted conservative B-cell epitope and a known K2d compatible T-cell epitope, was used to immunize mice, and then H pylori-specific antibodies were detected by ELISA. RESULTS: Based on the analyses of divergent amino acid residues, structural and physiochemical characteristics, it was strongly suggested that the short fragment NDSDGR was the core of a conservative linear epitope in flagellin A. Animals immunized by Pep29mer acquired efficient immune response. In detail, serum H pylori-specific IgA and IgGl increased significantly in immunized group, while IgG2a only had an insignificant change. H pylori-specific IgA in gastrointestinal flushing fluid also increased significantly. CONCLUSION: The conservative short fragment NDSDGR is the core of a linear B-cell epitope of flagellin A. 相似文献
84.
Antimicrobial peptides (AMPs) are small molecules produced by a myriad of cells and play important roles not only in protecting against infections and sustaining skin barrier homeostasis but also in contributing to immune dysregulation under pathological conditions. Recently, increasing evidence has indicated that AMPs, including cathelicidin (LL-37), human β-defensins, S100 proteins, lipocalin 2, and RNase 7, are highly expressed in psoriatic skin lesions. These peptides broadly regulate immunity by interacting with various immune cells and linking innate and adaptive immune responses during the progression of psoriasis. In this review, we summarize the recent findings regarding AMPs in the pathogenesis of psoriasis with a main focus on their immunomodulatory abilities. 相似文献
85.
高空减压病(altitude decompression sickness,ADS)是指在一定高度飞行时,大气压力迅速降低,原本溶解在机体组织与体液中的氮气呈现过饱和状态而离析出来形成气泡,压迫或栓塞局部组织产生的一种病症。ADS是一种比较常见的航空病,高空低气压的暴露使飞行人员面临着ADS的风险,在过去很长的一段时间,国内外学者针对ADS的病因、预防以及治疗做了大量工作,取得了大量的突破性进展,但近年来随着航空器性能的不断提升,ADS的防治又面临新的挑战,本文将对近年来国内外ADS的发病原因、治疗以及预防新进展做一综述。 相似文献
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线粒体和内质网的稳态在维持心血管正常功能中发挥重要作用,线粒体或内质网的结构功能异常参与了众多心血管疾病的发生发展。近年来研究发现线粒体与内质网存在物理和功能的交互,其交互作用调控线粒体、内质网功能,进而影响心肌细胞和平滑肌细胞的线粒体动力学平衡、钙转运及磷脂合成和转运。内质网–线粒体交互异常被认为是冠心病、心力衰竭、肺动脉高压和动脉粥样硬化等心血管疾病的关键机制。因此,理解内质网-线粒体交互机制可为预防和改善心血管疾病提供崭新靶点。 相似文献
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