A review for recent advances on soil washing remediation technologies

Contaminated soils have caused serious harm to human health and the ecological environment due to the high toxicity of organic and inorganic pollutants, which has attracted extensive attention in recent years. Because of its low cost, simple operation and high efficiency, soil washing technology is widely used to permanently remove various pollutants in contaminated soils and is considered to be the most promising remediation technology. This review summarized the recent developments in the field of soil washing technology and discusses the application of conventional washing agents, advanced emerging washing agents, the recycling of washing effluents and the combination of soil washing and other remediation technologies. Overall, the findings provide a comprehensive understanding of soil washing technology and suggest some potential improvements from a scientific and practical point of view.

     

ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis

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皮肤性病科实施临床路径的几点体会

分析了皮肤性病科临床路径的实践情况,从多角度剖析了实施过程中遇到的问题,并介绍了工作体会,旨在为今后皮肤性病学科临床路径的运行提供参考。     

Cerebral vasculitis caused by Talaromyces marneffei and Aspergillus niger in a HIV-positive patient: a case report and literature review

Journal of NeuroVirology - Cerebral vasculitis is a long-standing but flourishing and fadeless research topic. Infections are a frequent cause of cerebral vasculitis, vital to diagnose due to...     

皮肤磨削术及其应用

皮肤磨削术是在皮肤病的治疗及美容治疗中适应证较为广泛的一种治疗手段,是医学美容换肤技术在临床上最为常用的一种方法,磨削术常规是使用一些器械或设备,对表皮和真皮浅层进行可控制的机械性磨削、以完成治疗及美容的一种手术。不同类型的患者的治疗方法选择是有所区别的,医生应对不同患者选取不同的治疗方法及设备。本文通过综述结合临床病例治疗经验对皮肤磨削术的方法加以系统介绍,让大家重新认识皮肤磨削术这一古老而传统的治疗方法,对临床应用具有重要意义。     

机械磨削术联合氨基酮戊酸光动力疗法治疗手部Bowen病

目的:探讨机械磨削术联合氨基酮戊酸光动力疗法(ALA-PDT)治疗手部Bowen病疗效。方法:10例经病理确诊的手部Bowen病患者,均行机械磨削术联合ALA-PDT治疗。磨削时从外向里进行磨削,磨至弥漫性出血为止。后将氨基酮戊酸配成20%溶液涂于皮损及外周0.5cm,3~4h后行635nm红光照射,能量密度为80~100J/cm2,时间20min,每周照射1次,共3次。6个月后观察肿瘤有无复发,患者满意度及瘢痕形成等情况。结果:10例患者行机械磨削联合ALA-PDT治疗后,至少随访6个月,均未见肿瘤复发;10例患者均非常满意,治疗后无明显瘢痕增生。结论:机械磨削术联合ALA-PDT治疗手部Bowen病安全高效,痛苦小,创伤轻,患者满意度高,无明显瘢痕形成,值得临床推广。     

机械磨削术在皮肤外科的临床应用

目的:探讨机械磨削术在皮肤外科手术中的应用及临床效果。方法:选笔者科室2017年8月-2018年11月收治的机械磨削术治疗的患者107例,包括白癜风68例,酒渣鼻19例,疣状痣、炎性线状表皮痣16例,痤疮凹陷性瘢痕4例。术后随访1年,观察外观改善效果、皮损复发及瘢痕形成情况。结果:本组107例患者,非常满意率为77%(82/107),满意率为23%(25/107)。白癜风患者达80%复色52例,50%~80%复色16例;52例(76%)非常满意,16例(24%)满意。酒渣鼻患者均为鼻赘期,15例(79%)对外观改善非常满意,4例(21%)满意。疣状痣、炎性线状表皮痣患者12例(75%)非常满意,4例(25%)满意;1例炎性线状表皮痣位于手足的皮损约30%复发。痤疮凹陷性瘢痕患者3例(75%)非常满意,1例(25%)满意。结论:机械磨削术在皮肤外科应用于治疗白癜风、酒渣鼻、疣状痣、凹陷性瘢痕的临床及美学效果显著,满意度高。     

Oral delivery of capsaicin using MPEG-PCL nanoparticles

Aim:

To prepare a biodegradable polymeric carrier for oral delivery of a water-insoluble drug capsaicin (CAP) and evaluate its quality.

Methods:

CAP-loaded methoxy poly (ethylene glycol)-poly(ε-caprolactone) nanoparticles (CAP/NPs) were prepared using a modified emulsification solvent diffusion technique. The quality of CAP/NPs were evaluated using transmission electron microscopy, powder X-ray diffraction, differential scanning calorimetry and Fourier transform infrared techniques. A dialysis method was used to analyze the in vitro release profile of CAP from the CAP/NPs. Adult male rats were orally administered CAP/NPs (35 mg/kg), and the plasma concentrations of CAP were measured with a validated HPLC method. The morphology of rat gastric mucosa was studied with HE staining.

Results:

CAP/NPs had an average diameter of 82.54±0.51 nm, high drug-loading capacity of 14.0%±0.13% and high stability. CAP/NPs showed a biphasic release profile in vitro: the burst release was less than 25% of the loaded drug within 12 h followed by a more sustained release for 60 h. The pharmacokinetics study showed that the mean maximum plasma concentration was observed 4 h after oral administered of CAP/NPs, and approximately 90 ng/mL of CAP was detected in serum after 36 h. The area under the curve for the CAP/NPs group was approximately 6-fold higher than that for raw CAP suspension. Histological studies showed that CAP/NPs markedly reduced CAP-caused gastric mucosa irritation.

Conclusion:

CAP/NPs significantly enhance the bioavailability of CAP and markedly reduce gastric mucosa irritation in rats.