汞中毒对心血管疾病影响的研究进展

汞是危害人类健康的重金属之一，人体内血液汞的水平与心血管疾病(cardiovascular diseases, CVDs)的发生发展密切相关，但目前我国关于汞与CVDs之间的报告甚少。本研究将从汞对心血管系统的影响、汞通过干扰心血管线粒体钙稳态、诱导心血管线粒体功能障碍、诱导心血管的氧化应激、诱导脂质过氧化、诱导心血管内皮损伤等机制促进CVD进展进行综述。     

Catalyst-Free,Self-Healing,and Recyclable Tung Oil-Based Epoxy Vitrimers with Dynamic Ester Bonds

Low toughness and nonrecyclability severely limit the applications of traditional thermosets and are not in line with the concept of sustainable development. To solve these problems, water is used as the solvent, and a tung oil-based tetrafunctional carboxylic acid (TFA) curing agent is obtained through a “one-pot” method based on previous works. This green synthesis method is suitable for synthesizing tung oil-based polycarboxylic acid curing agents from various olefin-containing polyacids. At the same time, the vitrimers (DGEBA-TFA) are prepared with diglycidyl ether of bisphenol (DGEBA) as the skeleton, and applied to carbon fiber reinforced composites (CFRCs). The tensile strength, tensile modulus and elongation at break of DGEBA-TFA are 64.62 MPa, 2.55 GPa, and 4.31%, respectively, which are comparable to previous works. Hence, the performance of the vitrimers is not reduced while simplifying the experimental steps. Meanwhile, DGEBA-TFA exhibits excellent self-healing, shape memory, and recycling abilities. The vitrimers can be reprocessed without additional catalysts, and the recovery rate remained at 91.3% in the third cycle. DGEBA-TFA-CFs exhibite excellent tensile strength. This work solves the problems in previous works and makes TFA more likely to be applied into practical industrial production.     

LC-MS/MS法检测盐酸鲁拉西酮中磺酸酯基因毒杂质

目的：采用LC-MS/MS法检查盐酸鲁拉西酮中的痕量磺酸酯基因毒杂质。方法：采用Waters Atlantis T₃（2.1 mm×50 mm，3 μm）色谱柱，10 mmol·L^-1醋酸铵水溶液（55%）和甲醇（45%）作为流动相，等度洗脱，Agilent 1200色谱系统和Agilent 6460 MS/MS（ESI源）检测磺酸酯。结果：磺酸酯在0.05 ng·mL^-1至25.00 ng·mL^-1范围内线性良好，r＞0.999，加样回收率为85%～115%，样品溶液在恒温进样盘（4℃）中6 h稳定。结论：该方法灵敏度高、准确度良好，可用于盐酸鲁拉西酮中磺酸酯基因毒杂质的定量检测，并为质量控制提供参考。