The prognostic signature based on glycolysis-immune related genes for acute myeloid leukemia patients

Acute myeloid leukemia (AML) is widely considered an immunoresponsive malignancy. However, potential association between glycolysis-immune related genes and AML patients’ prognosis has been seldom studied. AML-related data was downloaded from TCGA and GEO databases. We grouped patients according to Glycolysis status, Immune Score and combination analysis, basing on which overlapped differentially expressed genes (DEGs) were identified. The Risk Score model was then established. The results showed that totally 142 overlapped genes were probably correlated with glycolysis-immunity in AML patients, among which 6 optimal genes were screened to construct Risk Score. High Risk Score was an independent poor prognostic factor for AML. In conclusion, we established a relatively reliable prognostic signature of AML based on glycolysis-immunity related genes, including METTL7B, HTR7, ITGAX, TNNI2, SIX3 and PURG.     

Morbihan病一例

患者，男，76岁。面部红斑、肿胀1年。皮肤科查体：中上面部对称性、弥漫性分布的红斑及非凹陷性水肿，皮损边界不清。皮损组织病理学示表皮大致正常，真皮浅层血管周围淋巴细胞为主的炎性细胞浸润。结合临床特点及组织病理学及特殊染色表现诊断为Morbihan病，目前长期随访中。     

中医药治疗调节癌因性疲乏患者免疫功能研究进展

癌因性疲乏是恶性肿瘤患者常见伴发症,发生率较高,影响患者的治疗和生活质量。中医药治疗手段对于癌因性疲乏有一定程度的改善,相关研究表明癌因性疲乏的发生可能与机体免疫功能有关,文章总结近年中医药治疗方法对于癌因性疲乏患者免疫功能影响的研究进展,为临床治疗癌因性疲乏提供新的思路。