Association between chronic hepatitis C infection and metabolic syndrome: A meta-analysis

BackgroundHepatitis C virus (HCV) infected patients have been found to be more susceptible to metabolic syndrome (MetS), but the results remain unclear and lack of a meta-analysis.MethodsDatabases including PubMed, Web of Science, EMBASE and the Cochrane Library were searched to identify all studies concerning HCV and MetS. Funnel plots combined with Begg's tests and Egger's tests were used to analysis the possible publication bias. The odds ratios (ORs) with 95% confidence intervals (CIs) were used to access the effect of HCV infection on the risk of MetS.ResultsEight articles, involving a total of 57387 HCV patients were included. HCV infection was significantly associated with an increased incidence of MetS (OR = 1.73; 95% CI, 1.19–2.52). After adjustment according to the sensitivity analysis, one included article was removed to decrease the publication bias and high heterogeneity, of which the results showed that HCV infection was still associated with an increased incidence of MetS (OR = 1.93; 95% CI, 1.39–2.68).ConclusionsHCV patients tend to have a significant increased risk for MetS, but more large-scale studies are needed to confirm this and explore the exact mechanism.     

肺部解脲脲原体感染对支气管肺发育不良影响的Meta分析

目的 分析肺部解脲脲原体(UU)感染对支气管肺发育不良(BPD)的影响,为早产儿BPD的防治提供依据。 方法 检索Pubmed、Embase、Web of Science、Cochrane Library、中国知网、万方、维普及中国生物医学数据库(CBM)8个数据库,收集关于肺部UU感染对BPD影响的队列研究,检验标本为气管内分泌物,检索时间为自建库至2020年4月15日,采用Stata 15.1软件对纳入研究进行Meta分析。 结果 共纳入21项研究,均为队列研究,其中18篇文献以生后28 d为评估结局,9篇文献以校正胎龄36周为评估结局,共包含研究对象3 039例,其中UU感染组831例,非UU感染组2 085例。随机效应模型显示,UU感染不会增加BPD的发病风险(出生后28 d评估:RR=1.69, 95%CI:1.42~2.01, 矫正胎龄36周评估:RR=1.20, 95%CI:0.91~1.58)。 结论 基于现有研究数据,不能确定UU感染是BPD的影响因素,尚需统一的BPD诊断标准以及更高质量的队列研究来探索UU感染与BPD之间的关系。     

肛周坏死性筋膜炎术后热毒炽盛期应用解毒消痈饮的疗效观察

[目的] 探讨解毒消痈饮治疗肛周坏死性筋膜炎术后热毒炽盛期的临床效果。[方法] 将60例肛周坏死性筋膜炎患者随机分为对照组和观察组,各30例。对照组采用术后对症支持的常规治疗+痛痒消洗剂坐浴,观察组在对照组的基础上,术后口服解毒消痈饮治疗。[结果] 观察组治疗后第3、7、14天视觉模拟评分量表（VAS）评分均低于对照组,差异具有统计学意义（P<0.05）;两组治疗14 d后白细胞（WBC）、C-反应蛋白（CRP）、白细胞介素-6（IL-6）较治疗前显著减低,且观察组明显低于对照组（P<0.05）,而血红蛋白（Hb）较治疗前明显升高,且观察组优于对照组（P<0.05）;两组治疗14 d后坏死性筋膜炎实验室风险指数评分（LRINEC）、Fournier坏疽严重程度指数（FGSI）均较治疗前显著减低,且观察组明显低于对照组（P<0.05）;观察组治疗后第7、14天创面渗液和创面水肿情况评分均低于对照组,差异具有统计学意义（P<0.05）;观察组创面愈合时间较对照组短（P<0.05）;观察组的总有效率优于对照组（P<0.05）。[结论] 肛周坏死性筋膜炎术后热毒炽盛期应用解毒消痈饮疗效确切,能够有效缓解术后疼痛,降低炎症反应,提高血红蛋白含量,有利于评估患者术后病情及预后,减轻术后创面渗液和创面水肿,加速创面愈合。     

模拟器训练在实施股动脉穿刺点ExoSealTM封堵止血系统操作的多中心对照研究

背景与目的：介入手术已成为血管外科的主要治疗手段,对于手术直接相关的股动脉穿刺点封堵处理是手术操作收尾的一个重要环节。鉴于国内外目前尚缺乏关于封堵止血系统模拟器训练应用效果的高级别证据,本研究旨在评估模拟器训练在实施股动脉穿刺点ExoSealTM封堵止血系统操作的临床应用效果以及在血管介入操作基础教学培训中的应用价值。 方法：采用前瞻性对照设计,选择2020年5月—2020年10月7个中心的8名血管介入医师分别用两种不同方式进行封堵操作培训。4名血管介入医师通过阅读ExoSealTM说明书和观看视频进行培训（对照组）,另4名血管介入医师的培训方式为在前者基础上增加专业人员指导下的模拟器使用（研究组）。培训结束后,在主诊医师监管下,每名医师对接受血管介入手术,并在股总动脉使用6 F鞘管的患者,采用ExoSealTM封堵止血系统对穿刺点进行封堵。两组医师各操作50例患者,比较两组的操作时间、出血量、器械成功率、股动脉栓塞发生率、二次干预率、24 h内发生血肿率。 结果：研究组在ExoSealTM封堵止血系统操作中,所需的操作时间和出血量均少于对照组（24.50 s vs. 30.00 s,P=0.003;8.60 mL vs. 11.22 mL,P=0.019）。研究组的器械成功率（98.0%）高于对照组（96.0%）,但差异无统计学意义（P=0.558）。两组均无动脉栓塞、二次干预和24 h内发生血肿情况。 结论：ExoSealTM封堵止血系统模拟器的训练能够提高股动脉封堵的安全性和有效性。该模拟器的训练应常规用于血管介入操作的基础教学培训中。     

GPBB、cTnI、CK、CKMB在急性心肌梗死伴糖尿病早期诊断中的临床应用价值

分析心肌梗死伴糖尿病患者血清中糖原磷酸化酶同工酶BB(GPBB)、肌钙蛋白I (cTnI)、肌酸激酶(CK)、肌酸激酶同工酶(CKMB)水平的变化。结果显示糖尿病组、单纯急性心肌梗死组及急性心肌梗死伴糖尿病组患者血清中GPBB、cTnI、CK、CKMB、BNP及超敏C反应蛋白(Hs-CRP)水平明显升高(P<0.05),且急性心肌梗死伴糖尿病组患者与其他组相比差异均有显著性(P<0.05);与GPBB、cTnI、CK、CKMB单独检测相比,各项目联合检测急性心肌梗死伴糖尿病敏感度和特异性均明显升高(P<0.05)。因此, GPBB、cTnI、CK、CKMB联合检测在急性心肌梗死伴糖尿病早期诊断中具有重要的参考价值。     

miR-224和 miR-378e在大肠癌组织中的表达及其临床意义

【摘要】 目的 探讨miR-224 和 miR-378e 在原位大肠癌癌组织和癌旁正常黏膜组织中的表达差异， 并分析其临床意义。 方法 miRNA 表达谱芯片技术检测大肠癌癌组织和癌旁组织标本中表达差异的miRNA， 运用荧光实时定量聚合酶链反应（real-time PCR）验证其结果，并分析其与临床病理资料之间的关系。 结果 miRNA 表达芯片分析发现， 与正常黏膜组织比较， miR-224在大肠癌组织中表达显著上调， miR-378e在大肠癌组织中表达显著下调， 并被 real-time PCR 所证实。 miR-224 在不同组织学类型癌组织中表达差异有统计学意义， miR-378e 在不同浸润深度癌组织中表达差异有统计学意义， miR-224 表达与组织学类型有关， miR-378e 表达与大肠癌浸润深度有关。 结论miR-224具有潜在的癌基因作用， miR-378e具有潜在的抑癌基因作用， miR-224和 miR-378e可作为     

Longitudinal diffusion tensor imaging of patients with degenerative cervical myelopathy following decompression surgery

Previous studies have reported the utility of diffusion tensor imaging (DTI) as an imaging biomarker for the severity of myelopathy and subsequent surgical outcome in patients with degenerative cervical myelopathy (DCM). We hypothesized that DTI may reflect neurological recovery following surgery. The purpose of this study was to evaluate the ability of DTI to assess the post-operative alteration of neural status in patients with DCM as well as to predict post-operative recovery. We enrolled 15 patients with DCM who underwent decompression surgery. The Japanese Orthopaedic Association (JOA) score was evaluated before and 1 year after surgery. The participants were examined using DTI on a 3.0 T magnetic resonance scanner before, and 1 year after surgery. Fractional anisotropy (FA) and mean diffusivity (MD) were assessed for both time points. The correlations between the pre- and post-operative FA and MD values and the pre- and post-operative JOA scores were analyzed. Although the JOA score improved significantly after surgery from 8.9 to 12.3, there was no significant change between the pre- and post-operative FA and MD values. The post-operative outcomes after 1 year moderately correlated with the pre-operative FA values (Spearman’s ρ = 0.55, p = 0.03 and Spearman’s ρ = 0.56, p = 0.03 for change and recovery rate of the JOA score, respectively). However, there was no correlation between the post-operative FA and post-operative JOA scores nor between MD and clinical outcomes. DTI cannot be utilized as a biomarker for post-operative alterations of neural status of the spinal cord; however, pre-operative DTI may be useful as a predictor of surgical outcomes.