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71.
B. Jamard J. Allard P. Caron J. X. Corberand A. Blanchard R. Vargas-Poussou S. El Mahou A. Constantin A. Cantagrel B. Mazières M. Laroche 《Osteoporosis international》2008,19(1):119-122
A 23-year-old man presented with osteoporosis, revealed by femoral fractures, and a history of nephrolithiasis, short stature,
metabolic acidosis, hypokalemia and ovalocytosis, a red blood cell abnormality common in malaria endemic regions. Biological
investigations led to the diagnosis of type 1 distal renal tubular acidosis (dRTA). Ovalocytosis and dRTA may co-exist in
the same patient, since both can originate in mutations of the anion-exchanger 1 (AE1) gene, which codes for band 3, the bicarbonate/chloride
exchanger, present in both the red cell membrane and the basolateral membrane of the collecting tubule alpha-intercalated
cell. 相似文献
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《Autoimmunity reviews》2022,21(12):103205
ObjectivesTo evaluate the outcomes of hospitalized patients in two intensive care units (ICU) treated with intravenous immunoglobulin (IVIg) added to standard-of-care therapy. The indications for IVIg therapy were sepsis or autoimmune disease.MethodsWe conducted a retrospective study involving adult patients with sepsis and autoimmune diseases, who received IVIg in the ICU at Wolfson and Sheba Medical Centers. A predefined chart was compiled on Excel to include a complete demographic collection, patient comorbidities, chronic medication use, disease severity scores (Charlson Comorbidity Index; SOFA and APACHE II index scores), indication and dosage of IVIg administration, duration of hospitalization and mortality rates.ResultsPatients (n - 111) were divided into 2 groups: patients with sepsis only (n-67) and patients with autoimmune disease only (n-44). Septic patients had a shorter ICU stay, received IVIg early, and had reduced mortality if treated with high dose IVIg. Patients with autoimmune diseases did not have a favorable outcome despite IVIg treatment. In this group, IVIg was administered later than in the sepsis group.ConclusionsIVIg therapy improved the outcomes for ICU patients with sepsis. 相似文献
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Ankana Daga Amar J. Majmundar Daniela A. Braun Heon Yung Gee Jennifer A. Lawson Shirlee Shril Tilman Jobst-Schwan Asaf Vivante David Schapiro Weizhen Tan Jillian K. Warejko Eugen Widmeier Caleb P. Nelson Hanan M. Fathy Zoran Gucev Neveen A. Soliman Seema Hashmi Jan Halbritter Friedhelm Hildebrandt 《Kidney international》2018,93(1):204-213
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