托吡酯治疗各类癫痫的疗效观察

目的:观察托吡酯单药治疗各类癫痫的临床疗效及安全性。方法:将我院2007年1月-2010年1月250例癫痫患者使用托吡酯单药治疗后的疗效进行统计、分析,并评价其安全性。结果:治疗后发作完全控制者68例(27.2%),显效64例(25.6%),有效56例(22.4%),总有效率为75.2%。治疗期间分别发生记忆力下降(13.6%)、体重减轻(8.8%)、恶心(7.2%)、言语障碍(5.6%)、嗜睡(4.8%)、头昏(4.4%)、低热(3.2%)、肾结石(2.8%)等不良反应。结论:托吡酯单药治疗癫痫疗效显著,完全控制率高,不良反应较轻。     

蜂针治疗膝骨性关节炎的临床观察

目的 观察蜂针治疗不同中医证型膝骨性关节炎的临床疗效,分析总结蜂针治疗本病的适宜中医证型.方法 按照中医辨证将膝骨性关节炎分为行痹、痛痹、着痹、热痹4个证型组,用活蜂蛰刺患膝阿是穴、内外膝眼、鹤顶穴、梁丘、血海.每周治疗2次,2周为l疗程.结果 蜂针疗法治疗膝骨性关节炎中,痛痹组及着痹组的总有效率、症状体征评分的改善情况明显优于行痹组及热痹组（P＜0.05）.结论 蜂针疗法更适合痛痹、着痹证型的膝骨性关节炎.     

多发性硬化后阴痛1例

A female patient with vaginal pain induced by multiple sclerosis was treated by acupuncture. Her chief complaint: pricking vaginal pain during intercourse for 1 year. Electroacupuncture was applied to Shènshū (肾俞 BL23), Huìyáng (会阳 BL35), Cìliáo (次髎 BL32) and Zhōngliáo (中髎 BL33) on lumbosacral region. The disperse wave was adopted firstly, followed by the dense wave in stimulation. The stimulation intensity was determined by the patient's tolerance. The needles were retained for 50 min totally. After 2-month treatment, the sexual function of the patient was recovered to be normal. The sexual activity was normal in 1-year follow-up and vaginal pain was not recurred.     

Comparative analysis of the efficacy and safety of herbal decoction CheReCunJin alone and combined with hydroxychloroquine for treating primary Sjögren's syndrome: A randomized controlled trial

IntroductionThere is currently no established effective treatment for primary Sjögren's syndrome (pSS). Traditional Chinese Medicine (TCM) is widely used in China and is reported to improve patient symptoms. This study compare the clinical efficacy and safety of herbal decoction CheReCunJin alone and combined with hydroxychloroquine for the treatment of pSS.MethodsSeventy pSS patients without visceral involvement were randomly assigned in equal numbers to oral administration of CheReCunJin decoction only (group 1) or CheReCunJin decoction combined with hydroxychloroquine (group 2), Efficacy was evaluated after 3 months of treatment by the TCM syndrome and total effectiveness scores, European League Against Rheumatism (EULAR) Sjögren's Syndrome Patient Reported Index (ESSPRI), and Sjögren's Syndrome Disease Activity Index (ESSDAI), Schirmer's test, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and immunoglobulin G (IgG) levels. Safety was assessed.ResultsThere were no differences in the baseline characteristics of the two groups. Compared with baseline values, the TCM syndrome, ESSPRI and ESSDAI scores, ESR, CRP, and Schirmer's test results improved significantly in both groups after treatment (p < 0.05). There was no significant difference in the TCM syndrome total effectiveness rate between the two groups (p = 0.31). Between-group differences in the changes in ESSPRI, ESSDAI, ESR, CRP, Schirmer's test, and IgG after treatment were not significant (all p> 0.05). Adverse reactions were reported in 5.88% of group 1 and 3.33% of group 2 participants (p = 0.83).ConclusionCheReCunJin decoction alone was effective and safe for the treatment of pSS.Trial registrationChinese Clinical Trial Registry: ChiCTR1800016471     

Effect of six months pranayama training on stress-induced salivary cortisol response among adolescents-Randomized controlled study

BackgroundA combination of yoga practices has been documented to reduce stress and stress-induced cortisol levels. The objective of the current study is to examine the effects of six months of a single pranayama practice (Bhramari [Bhr. P]) on reducing salivary cortisol response to the cold pressor test (CPT) among adolescents.MethodsTwenty-six healthy adolescents between the ages of 11 and 19 were randomly assigned to either yoga group (n-13) or control group (n-13). Yoga group participants were trained to do Bhr. P for 45 min, thrice a week for six months. All participants underwent CPT at baseline and at end of six months. Saliva samples were collected at baseline (t0), at 20 min (t1), 40 min (t2), and 60 min after the CPT (t3).ResultsContradictory to our hypothesis, participants in the yoga group exhibited a higher salivary cortisol response to the CPT at t1 (p = 0.04) when compared to the control group. However, the t3 salivary cortisol levels showed a statistically significant reduction (p = 0.03) in yoga group when compared to the control group. A significant interaction with time (F (1, 88) = 316.5, p = .001, ηp²:0.91) and between the group × time (F (3, 88) = 2.83, p = 0.04, ηp²:0.8) was found after the intervention.ConclusionsAn increase in the cortisol responsiveness observed in the study is an indication of the adaptive capability achieved through regular yoga training, evidenced by an initial rise in cortisol followed by a rapid fall below baseline after 60 min. Further research is required to conclusively determine the changes in cortisol levels over time in response to stress in long-term yoga practitioners.     

‘Making a difference’ a clinical pathway for hip fractures and the advance practice role in managing patients with minimal trauma hip fractures

BackgroundIn 2006/2007 there were estimated over 16,500 patients with hip fractures in Australia, the majority (94%) were over 65 years. Patients with hip fractures nearly always require hospitalisation and surgery.AimThe aim of this study was to assess the impact of the hip fracture clinical pathway on care of the hip fracture patient.MethodThis study is a retrospective medical record audit of all minimal trauma hip fracture patients over 65 years in a large tertiary hospital over a three month period before and after implementation of the hip fracture clinical pathway.ResultsFor patients in the intervention group (n = 28, mean 86.0 years) compared with the control group (n = 33, mean 85.7 years) time to surgery was <24-h (92.9% vs. 51.5%, p = 0.001), the venous thromboembolism (VTE) risk assessment form was completed (21.4% vs. 0%, p = 0.004), VTE prophylaxis improved, fewer patients received no prophylaxis (0% vs. 33.3%, p = 0.001), pharmacological prophylaxis only (21.4% vs. 54.4%, p = 0.008) and more patients received pharmacological prophylaxis and graduated compression stockings (75.0% vs. 12.1%, p = 0.001) and were discharged with osteoporosis treatment calcium and vitamin D (35.7% vs. 6.1%, p = 0.008).ConclusionImplementation of the hip fracture clinical pathway improved time to surgery (<24 h), VTE risk assessment and prophylaxis, and osteoporosis treatment on discharge.     

Correction to: A novel compound heterozygous mutation of von Hippel‑Lindau gene in a Chinese patient with erythrocytosis

Annals of Hematology -     

济生乌梅片防治大肠息肉内镜治疗后再复发的临床研究

目的观察济生乌梅片防治大肠息肉内镜治疗后再复发的临床疗效。方法将患者64例随机分为两组，治疗组33例采用服济生乌梅片，对照组31例服安慰剂；利用电子肠镜观察两组治疗后的疗效及复发情况。结果治疗组治疗大肠息肉复发率大幅降低，明显优于对照组。治疗组和对照组的1年后复发率分别为3．03％、6．45％，2年后复发率分别为6．06％、16．12％，3年后复发率分别为9．O％、32．3％，差异有统计学意义（P〈0．05或P〈0．001）。结论济生乌梅片可有效控制大肠息肉内镜治疗后的再复发。