电针董氏奇穴联合生物反馈治疗功能性肛门直肠痛的疗效评价

ObjectiveTo investigate the clinical effect of electroacupuncture combined with biofeedback on functional anorectal pain.MethodsSixty patients diagnosed functional anorectal pain were divided into three groups by random number table, namely electroacupuncture group, biofeedback group, and combination group, with 20 patients in each. In the electroacupuncture group, the electroacupuncture at Dong's points Sānqí (三其穴), including Qímén (其门), Qíjiǎo (其角), and Qízhèng (其正), and Línggǔ (灵骨), Dàbái (大白), Chángmén (肠门) of both sides was given; in the Biofeedback group, the biofeedback therapy was adopted; in the combination group, the electroacupuncture and biofeedback therapy were used. All patients were treated once a day, 30 min each time, 10 consecutive treatments as one treatment course, and the therapeutic effect was evaluated after 3 treatment courses. The observation indexes after the intervention: Visual analogue Scale (VAS) score, SF-36 Quality of Life Scale score, Self-rating Anxiety Scale (SAS) score, Self-rating Depression Scale (SDS) score, Anorectal manometry, Clinical efficacy, and patients’ adverse reactions.ResultsAfter treatment, the pain of patients in the three groups was alleviated than that before treatment, VAS score, SAS score, SDS score, and anorectal pressure were decreased (P<0.05), and SF-36 Quality of Life Scale score was increased (P<0.05). After treatment, in the combination group, the VAS scores, SAS scores, SDS scores, and Anal-rectal pressure scores were lower than those in the other two groups (P<0.05), and SF-36 Quality of Life Scale scores were higher than those in the other two groups (P<0.05), the total effective rate was 80.0% (16/20), which was significantly higher than that of the electroacupuncture group (55.0%, 11/20) and the biofeedback group (40.0%, 8/20) (both P<0.05) . No adverse reactions occurred in all three groups.ConclusionElectroacupuncture at Dong's points combined with biofeedback therapy has a significant effect on functional anorectal pain. The combined application of electroacupuncture and biofeedback therapy has a synergic action, and the analgesic effect is better than that of only using electroacupuncture or biofeedback therapy.     

穴位埋线配合隔姜灸治疗周围性面瘫后遗症及其对表面肌电图的影响

ObjectiveTo explore the therapeutic effect of acupoint catgut embedding combined with ginger-separated moxibustion for sequelae of peripheral facial paralysis and whether surface electromyography (sEMG) can be an outcome to evaluate the effect of this disease.MethodsThirty-five patients with sequelae of peripheral facial paralysis were treated with catgut embedding at the acupoints selected according to their individual symptoms and traditional Chinese medicine (TCM) differentiated syndromes. At the same time, the ginger-separated moxibustion was applied at Yīfēng (翳风 TE17) and Qiānzhèng (牵正 EX-HN16) of the affected side. The catgut embedding was applied once every 15 days, one time of treatment is of one course, and a total of three courses were given. The moxibustion would be taken after 5 days of catgut embedding each time, once every other day, 5 times as one course, a total of 3 courses are given. After treatment, the recovery of facial nerve functions was evaluated by House–Brackmann (H-B) facial nerve function evaluation grading system. Before and after treatment, the surface electromyography (sEMG) was used to detect the root-mean-square (RMS) of frontal muscles, cheek muscles, and orbicularis oris muscles to compare the RMS ratio of these muscles of affected side and healthy side.ResultsAfter 3 courses of treatment, 9 cases were cured, 22 cases were effective, and 4 cases were ineffective. The total effective rate was 88.6% (31/35). After treatment, the RMS of frontal muscles, cheek muscles, and orbicularis oris muscles of the affected side were 31.56±4.25, 34.13±4.28, and 7.46±1.53 respectively, significantly increased in comparing with 11.69±2.45, 12.98±3.34, and 2.62±1.41 respectively before treatment (all P<0.05). After treatment, the RMS ratios of frontal muscles, cheek muscles, and orbicularis oris muscles of the affected side and healthy side were 0.73±0.09, 0.71±0.11, and 0.68±0.08 respectively, greatly increased in comparing with 0.28±0.10, 0.27±0.08, and 0.22±0.09 respectively before treatment (all P<0.05).ConclusionAcupoint catgut embedding and ginger-separated moxibustion in combination can significantly improve the facial nerve functions, and sEMG used for evaluating the therapeutic effect can objectively reflect the effect of treatment.     

IL-35通过诱导T细胞分化促进肺癌肿瘤进展

目的 探究肺癌中IL-35对T细胞表型及对癌症进展的影响.方法 建立小鼠肺癌移植瘤模型,施用IL-35中和抗体,监测肿瘤生长情况.并通过检测肿瘤中T细胞的浸润情况及其表型和细胞因子分泌情况,进一步探究对抗肿瘤免疫反应的影响.最后通过对肿瘤浸润T细胞的体外刺激实验,检测浸润T细胞的抗肿瘤活性.结果 瘤体积及瘤重的检测结果...     

四维盆底超声检测初产妇盆底功能障碍性疾病的使用价值

目的 探讨四维盆底超声在初产妇盆底功能障碍性疾病中的使用价值.方法 选取2018年3月—2019年5月间本院收治的初产妇盆底功能障碍性患者共82例,根据其不同分娩方式分为A组(剖宫产组,50例)及B组(阴道分娩组,32例).两组患者均行四维盆底超声进行检查,对比观察两组患者Green分型、Valsalva期BSD、尿道...     

参芪消痞汤对慢性萎缩性胃炎癌前期病变患者肿瘤标志物及血清p53蛋白、MDA、GSH-Px的影响

目的:观察参芪消痞汤对慢性萎缩性胃炎(chronic atrophic gastritis,CAG)癌前期病变患者肿瘤标志物及血清p53蛋白、丙二醛(monochrome display adapter,MDA)、谷胱甘肽过氧化物酶(glutathion peroxidase,GSH - Px)的影响.方法:78例CA...     

针刺手三里穴位动态超声显像

目的动态观察手三里穴位在针刺条件下的超声影像学解剖特征。方法选取健康志愿者15名,采用高频超声观察针灸针刺入受试者双侧手臂手三里穴后针尖的位置,以及针刺过程中与得气相关的解剖学结构。结果针刺15名受试者双侧手三里穴共30个穴位点均得气,针尖位置:桡侧腕伸肌13个,桡侧腕伸肌与旋后肌间筋膜9个,旋后肌浅层2个,旋后肌内筋膜4个,旋后肌深层1个,桡骨表面1个。28个(28/30,93.33%)针尖位于筋膜旁及筋膜集中处获得较强得气感、2个(2/30,6.67%)针尖位于较浅层即可获得较强得气感。高频超声可以清楚显示针尖点附近筋膜内的细小神经,二维声像图表现:桡神经深支沿着筋膜发出许多细小的分支,横断面声像图上呈筛孔样、回声较周围筋膜组织稍低。结论高频超声可以实时、动态、清楚地显示针刺点附近筋膜及筋膜内的细小神经分布,并可对针灸位置进行定量测定。     

彩色多普勒超声与钼靶X线摄影对乳腺良恶性肿块的诊断价值

目的探讨彩色多普勒超声与钼靶X线摄影对乳腺良恶性肿块的诊断价值。方法对130例乳腺肿块患者进行彩色多普勒超声与钼靶X线摄影单独和联合诊断,并与术后病理结果进行对照。结果该组恶性病变97例,良性病变33例。彩色多普勒超声检查的敏感性为72.16%,特异性为63.64%及准确性为70.00%,钼靶X线摄影检查的敏感性为80.41%,特异性为66.67%及准确性为76.92%,两者联合检查的敏感性为97.94%,特异性为87.88%及准确性为95.38%。结论两者联合应用可明显提高乳腺肿块的诊断符合率,为临床提供诊断依据。     

常规针刺联合隔姜灸对神经根型颈椎病的治疗效果观察

目的探讨常规针刺联合隔姜灸对神经根型颈椎病的治疗效果。方法选取2018年1—12月重庆市某医院收治的神经根型颈椎病患者200例为研究对象,采用随机数字表法将患者分为A组(常规针刺)、B组(常规针刺+隔姜灸3壮)、C组(常规针刺+隔姜灸5壮)、D组(常规针刺+隔姜灸7壮),每组50例。比较治疗前后4组患者颈部平均温度;比较4组患者的临床治疗效果。结果治疗后,4组患者颈部平均温度均高于治疗前,同时B、C、D组患者颈部平均温度均高于A组,C、D组患者颈部平均温度高于B组,差异均有统计学意义(P<0.05)。治疗后,C组和D组患者颈部平均温度比较,差异无统计学意义(P>0.05)。B、C、D组患者治疗总有效率均高于A组,C、D组治疗总有效率均高于B组,差异均有统计学意义(P<0.05)。同时,C组和D组治疗总有效率比较,差异无统计学意义(P>0.05)。结论常规针刺联合隔姜灸5壮治疗神经根型颈椎病的临床效果显著,其可改善患者颈部温度,提高治疗有效率,值得临床推广应用。     

甲状腺相关眼病的放射治疗研究进展

甲状腺相关眼病(TAO)是成人最常见的眼眶疾病,发病率逐年增高,临床表现为眼球突出、眼睑退缩、眼球运动障碍及视力障碍,严重损害患者的生理和心理健康。西医常用糖皮质激素治疗、放射治疗和眼眶减压术等。其中,糖皮质激素治疗是针对中重度活动性TAO患者的一线治疗方案;眼眶减压术主要针对严重眼球突出、眶压增高导致视神经受压损伤患者;而对于不耐受或禁用糖皮质激素以及拒行眼眶减压术的TAO患者,可选用放射治疗。放射治疗通过发挥非特异性抗炎作用,能有效地改善患者临床症状,是治疗TAO的重要手段。随着计算机技术和医学影像学不断更新,放射治疗技术取得快速发展,三维适形放射治疗及调强放射治疗技术的出现使病灶精准定位成为可能。大量临床结果表明放射治疗TAO疗效好、不良反应可控。本文就放射治疗TAO的作用机制、技术特点、临床方案、放射剂量参数选择及并发症进行综述,以期为同行提供临床参考,制定个性化的TAO治疗方案。