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??OBJECTIVE To investigate the clinical effect of pharmacist-nurse co-managed program on health education on the management of coronary heart disease. METHODS Consult literature related to pharmacists and nurses cooperation on health education for coronary heart disease patients, and combine actual clinical needs and work experience, pharmacist-nurse co-managed program on medication education of coronary heart disease was been preliminary established in cardiology department in our hospital. RESULTS The pharmacist-nurse co-managed program can improve the patients concern for pharmacological actions, dosage and precautions for drugs. Compared with the traditional nurses health education, pharmacist-nurse co-managed program significantly improved the drug compliance of patients from 31% to 92.5%. The 90% of the patients hope to accept long-term follow-up.The role of pharmacists improved in the health team. The clinical outcomes was improved. CONCLUSION Clinical pharmacists certainly play a role in the medical teams.Pharmacist-nurse co-managed program is effective in improving the clinical outcome and reduce the adverse drug reactions. A long-term follow-up system is needed in the future.     

Effect of inclination and anteversion angles on kinematics and contact mechanics of dual mobility hip implants

BackgroundSteep inclination and excessive anteversion angles of acetabular cups could result in adverse edge-loading. This, in turn, increases contact pressure and impingement risk for traditional artificial hip joints. However, the influence of high inclination and anteversion angles on both the kinematics and contact mechanics of dual mobility hip implants has rarely been examined.MethodsThis study focuses on investigating both the kinematics and contact mechanics of a dual mobility hip implant under different inclination and anteversion angles using a dynamic explicit finite element method developed in a previous study.FindingsThe results showed that an inclination angle of both the back shell and liner ranging from 30° to 70° had little influence on the maximum contact pressure and the accumulated sliding distance of inner and outer surfaces of the liner under normal walking gait. The same results were obtained for an anteversion angle of the liner varying between −20° and +20°. However, when the anteversion angle of the liner was beyond this range, the contact between the femoral neck and the inner rim of the liner occurred. Consequently, this caused a relative rotation at the outer articulation.InterpretationsThis suggests that both inclination and modest anteversion angles have little influence on the kinematics and contact mechanics of dual mobility hip implants. However, too excessive anteversion angle could result in a rotation for this kind of hip implant at both articulations.     

正交试验优选蒽酮 硫酸法测定蒙药“那仁满都拉”水溶性糖含量条件

摘 要 目的： 优选蒽酮 硫酸法测定蒙药“那仁满都拉”水溶性糖含量试验条件,并对蒙药“那仁满都拉”水溶性糖进行含量测定。方法: 在单因素试验基础上,对影响水溶性糖含量测定的四个因素：反应温度、反应时间、硫酸浓度,蒽酮浓度进行正交试验设计,优选最佳测定条件。结果: 蒽酮 硫酸法测定蒙药“那仁满都拉”水溶性糖含量的最佳条件为：反应温度80℃、反应时间45 min、硫酸浓度75%、蒽酮浓度0.2%。在此条件下,葡萄糖在2.040 0～32.580 0 mg·mL^-1范围内线性关系良好,r=0.999 6,平均回收率为101.88%,RSD为0.69%。三批样品含量测定的RSD均小于0.95%。结论: 用蒽酮 硫酸法测定“那仁满都拉”中的水溶性糖含量时,显色条件对定量有不容忽视的影响。     

The study on the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of nerve root sciatica: A protocol for systematic review and meta-analysis of randomized controlled trials

Background:Nerve root sciatica (NRS) is a common orthopedic disease, which usually occurs between 20 and 40 years of age, and the incidence rate is increasing year by year and is being younger. The disease has no special effect of treatment, clinically generally taking the symptomatic treatment, such as taking short-term glucocorticoids, sedatives, analgesics, and so on. Long-term use of drugs will adversely affect the patient''s gastrointestinal tract, liver, and kidney function. The surgical treatment has a high risk of surgery, high cost, side effects, and other problems, so the choice of treatment method has always been a difficult problem in clinical and scientific research. The study shows that 90% of patients with sciatica can be cured by non-surgical treatment, so conservative therapy is often used in the treatment of sciatica, traditional Chinese medicine treatment methods in the treatment of NRS has been widely used, which has achieved good results, but there is no evidence of evidence-based medicine. Therefore, this study uses systematic evaluation to conduct the scientific evaluation of the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of NRS, and provide evidence-based medical evidence support for the treatment of NRS.Methods:Using the computer to retrieve the PubMed, ScienceDirect, Web of Science, Embase, Cochrane Library, CNKI, VIP, WANFANG Database, and CBM. Using the subject words and terminology words to retrieve the Chinese-English database and retrieve a randomized controlled study on the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of NRS, and the range of search time is January 1990 to January 2021. The searched literature is screened and evaluated by two researchers respectively according to the inclusion and exclusion criteria. If there is disagreement, discussing it with the third researcher to determine the final inclusion of the literature. Using the RevMan 5.3 software to conduct the meta-analysis.Results:This study will compare the effectiveness and safety of traditional Chinese medicine acupoint catgut embedding guided by musculoskeletal ultrasound in the treatment of NRS.Conclusion:The results of this study will be published in internationally influential academic journals to provide evidence-based medical evidence for the clinical effectiveness and safety of traditional Chinese medicine acupoint catgut embedding in the treatment of NRS.Ethics and dissemination:This study does not involve specific patients, and all research data comes from publicly available professional literature, so an ethics committee is not required to conduct an ethical review and approval of the study.OSF registration number:DOI 10.17605/OSF.IO/Q492E.     

Prevalence and Risk Factors for Osteopathy in Chronic Pancreatitis

Digestive Diseases and Sciences - The high incidence of osteopathy among patients with chronic pancreatitis (CP) has garnered increased attention over recent years. The aims of this study were to...     

Protective effect of catalpol on lipopolysaccharide-induced acute lung injury in mice

Catalpol, an iridiod glucoside isolated from Rehmannia glutinosa, has been reported to have anti-inflammatory properties. Although anti-inflammatory activity of catalpol already reported, its involvement in lung protection has not been reported. Thus, we investigated the role of catalpol on lipopolysaccharide (LPS)-induced acute lung injury in this study. Mice acute lung injury model was induced by intranasal instillation of LPS. Catalpol was administrated 1 h prior to or after LPS exposure. The severity of pulmonary injury was evaluated 12 h after LPS administration. The results showed that catalpol inhibited lung W/D ratio, myeloperoxidase activity of lung samples, the amounts of inflammatory cells and TNF-α, IL-6, IL-4 and IL-1β in BALF induced by LPS. The production of IL-10 in BALF was up-regulated by catalpol. In vitro, catalpol inhibited TNF-α, IL-6, IL-4 and IL-1β production and up-regulated IL-10 expression in LPS-stimulated alveolar macrophages. Moreover, western blot analysis showed that the activation of NF-κB and MAPK signaling pathways was inhibited by catalpol. Furthermore, catalpol was found to inhibit TLR4 expression induced by LPS. In conclusion, catalpol potently protected against LPS-induced ALI. The protective effect may attribute to the inhibition of TLR4-mediated NF-κB and MAPK signaling pathways.     

幼年特发性关节炎诊疗规范

幼年特发性关节炎(JIA)临床上常见亚型包括全身型JIA、少关节型/多关节型JIA和幼年脊柱关节炎。本病无特异性诊断指标, 需与感染性疾病和恶性病相鉴别。全身型JIA起病多急骤, 病情进展快, 易合并巨噬细胞活化综合征而危及生命。儿童风湿科医生对JIA的诊断及治疗经验仍不足, 规范化诊疗水平有待进一步提高。中华医学会风湿病学分会组织有关专家, 在借鉴国内外诊疗规范和分类标准的基础上, 制定本规范, 旨在规范JIA各亚型及全身型JIA合并巨噬细胞活化综合征的诊断和治疗方案, 以降低致死率和严重并发症的发生率, 从而改善患儿预后。     

人性化护理在颅内动脉瘤血管内栓塞治疗围手术期的护理效果评价

目的:探讨人性化护理在颅内动脉瘤血管内栓塞治疗围手术期的护理效果。方法:将178例颅内动脉瘤患者随机分为观察组和对照组各89例,2组患者均给予血管内栓塞治疗,对照组给予常规围术期护理,观察组给予围术期人性化护理,比较2组患者护理前后焦虑情绪、生理指标及术后并发症发生率。结果:观察组术前30min收缩压、舒张压、呼吸频率、心率均低于对照组,差异有统计学意义(P<0.05);观察组出院前HAMA、SAS评分均低于对照组,差异有统计学意义(P<0.05);观察组并发症发生率显著低于对照组,差异有统计学意义(P<0.05)。结论:人性化护理减少了颅内动脉瘤患者术后并发症的发生,减轻了术前应激反应,缓解了患者焦虑情绪。     

针对性护理对脑肿瘤患者伽马刀术后颅内压的影响

目的:探究针对性护理对脑肿瘤患者伽马刀术后颅内压等不良反应指标的影响。方法:选取2011年1月至2013年12月来我院就诊的需行伽马刀治疗的脑肿瘤患者88例,依据分层随机分组法将患者分为治疗组及对照组,对照组44例术后给予常规护理方案及治疗策略进行治疗;治疗组44例术后给予针对性个体化护理方案进行治疗;观察比较两组患者治疗满意度、不良反应情况及治疗效果。结果:治疗前两组患者的颅内压比较差异无统计学意义(P>0.05);治疗后治疗组患者颅内压(196.75±37.14)mm H2O、住院时间(13.27±3.18)d、出现癫痫发病0(0.00%)例、头皮破溃5(11.63%)例及头皮感染例数2(4.65%)例明显低于对照组(217.68±42.59)mm H2O,(15.46±3.53)d,5例(11.36%),13例(29.55%),9例(20.45%),差异有统计学意义(P<0.05);治疗组患者治疗满意度高于对照组,差异有统计学意义(P<0.05);治疗组患者出现头痛、呕吐及视乳头水肿等脑水肿症状例数明显低于对照组,差异有统计学意义(P<0.05)。结论:针对性个体化护理可有效降低患者不良反应出现率及严重程度,提高患者生活质量并促进患者的早日康复。     

Association of weight-adjusted-waist index with all-cause and cardiovascular mortality in China: A prospective cohort study

Background and aimsAs a new simple anthropometric index, the weight-adjusted-waist index (WWI) appears to be superior to body mass index (BMI) and waist circumference (WC) in assessing both muscle and fat mass. We aimed to explore the association of WWI with all-cause and cardiovascular mortality in southern China.Methods and resultsA total of 12,447 participants (mean age, 59.0 ± 13.3 years; 40.6% men) in Jiangxi Province from the China Hypertension Survey study were included. WWI was defined as WC divided by the square root of weight. The outcome was all-cause and cardiovascular mortality. During a median follow-up of 5.6 years, 838 all-cause deaths occurred, with 390 cardiovascular deaths. Overall, there was a nonlinear positive relationship of WWI with all-cause and cardiovascular mortality. Accordingly, compared with participants in quartiles 1–3 (<11.2 cm/√kg), a significant higher risk of all-cause mortality (HR: 1.36, 95% CI: 1.17, 1.58) and cardiovascular mortality (HR: 1.43, 95% CI: 1.15, 1.77) were found in quartile 4 (≥11.2 cm/√kg). Further adjustment for BMI and WC did not substantially alter the results. No significant interactions were found in any of the subgroups (sex, age, area, physical activity, current smoking, current alcohol drinking, hypertension, and stroke).ConclusionHigher WWI levels (≥11.2 cm/√kg) were associated with increased the risk of all-cause and cardiovascular mortality in southern China. These findings, if confirmed by further studies, suggested that WWI may serve as a simple and effective anthropometric index in clinical practice.