Subjective assessment and cardiovascular response to ischemic pain in young, healthy women users and non-users of oral contraceptives

Experimental pain was introduced in women volunteers, some of whom were taking oral contraceptives. Pain perception and tolerance were the same, regardless of oral contraceptive use. All responded to the introduction of pain with increasing heart rate (HR), blood pressure (BP) and the product of systolic pressure, HR and the left ventricular ejection time (LVET). The users had a more consistent response pattern, and their reported levels of pain were positively and highly correlated with the changes in pre-ejection period (PEP) and the ratio PEP/LVET. Non-users had more variable systolic time interval (STI) responses.     

The effect of estrous cycle and buthionine sulfoximine on glutathione release from the in vitro perfused rat ovary

There is little known regarding the intracellular mechanisms of modification of damage in the ovary. Ovarian perfusion of en block dissections of the rat right ovary with aorta and vena cava were done to determine (a) if glutathione (GSH) is released by the ovary, (b) if the release is cycle dependent, and (c) if GSH released is the product of de novo ovarian synthesis. All perfused ovaries released GSH and the release was maximal at estrus and least at metestrus. Perfusion with buthionine sulfoximine, a specific inhibitor of γ-glutamylcysteine synthetase, resulted in a dose-dependent reduction in GSH released, indicating inhibition of de novo synthesis during perfusion.     

Distribution and determinants of low birthweight in Central Sudan

Summary. Two studies were conducted during 1989-90 in Central Sudan to determine the incidence of low birthweight and to ascertain the major risk factors which influence birthweight. In a hospital-based investigation, surveillance of all births was accompanied by a nested case-control study, and in a community based investigation, all midwife-assisted births were studied. There were 4868 and 1523 livebirths among the hospital and community populations, respectively. The incidence of low birthweight was 18.1% in the community and 8.2% in the hospitals. The ratio of term to pre-term low birthweight was 2.9 in the community but only 1.3 in the hospitals. Several risk factors showed consistent and significant associations with low birthweight in the hospital and community studies. Two important and modifiable predictors of term and preterm low birthweight were low maternal weight and malaria infection during pregnancy. Other risk factors included low socio-economic status and, among the hospital population, lack of antenatal care, short birth intervals, poor obstetric history and complications of pregnancy.     

8-溴-7-甲氧基白杨素对人卵巢癌A2780 细胞凋亡的作用及其机制

目的探讨8-溴-7-甲氧基白杨素（8-bromo-7-methoxychrysin, BrMC）诱导人卵巢癌A2780细胞凋亡的作用及其可能机制.方法采用不同浓度（2.5、5.0和10.0μmol·L^-1）的BrMC处理体外培养的A2780细胞,通过碘化丙啶（PI）染色流式细胞术（FCM）和ELISA法检测细胞凋亡的情况,Western Blot检测Bim和caspase-3蛋白的表达水平.结果不同浓度（2.5、5.0和10.0μmol·L^-1）BrMC均可促进A2780细胞的凋亡,且细胞凋亡率随BrMC浓度的升高而上升.不同浓度（5.0和10.0μmol·L^-1）BrMC作用的A2780细胞中Bim蛋白的表达均较正常对照组显著增加,而通过siRNA干扰下调Bim蛋白的表达能显著抑制BrMC诱导的A2780细胞凋亡.结论 BrMC可诱导人卵巢癌A2780细胞凋亡,促进Bim蛋白的表达可能是其作用机制之一.     

异位葡萄胎妊娠早期临床特点及诊疗：附二例报道

异位葡萄胎在临床上可以引起严重的并发症，其发病率极低，且易被漏诊、误诊。本文报道了2例异位葡萄胎患者的临床表现及病理诊断结果。患者1为部分性葡萄胎，患者2为完全性葡萄胎合并宫颈恶性肿瘤，两例患者临床上均表现为异位妊娠，并首先按照异位妊娠治疗，造成了误诊、误治；均采取手术治疗，术后病理检查确诊为异位葡萄胎。后续又补充治疗，得以痊愈。以上两例患者的诊断和治疗上均有欠缺，本文结合相关文献对病例资料进行分析总结，阐述异位葡萄胎典型临床表现和最新治疗研究进展，以期引起临床医师的重视，为早期诊断及治疗提供支持。     

Glucose regulation and grip strength in adults: Findings from the Helsinki Birth Cohort Study

AimThis study aimed to assess the association between grip strength and glucose regulation in a cross-sectional setting.MethodsUsing data from the Helsinki Birth Cohort Study, 924 men and 953 women were studied at a mean age of 61.6 years. Grip strength was assessed in the dominant hand using a Newtest Grip Force dynamometer. A standard 2-h 75 g oral glucose tolerance test (OGTT) was used to define glucose regulation. The participants were classified into four groups: normoglycaemia, prediabetes (impaired fasting glucose or impaired glucose tolerance), newly diagnosed diabetes and previously known diabetes. The association between grip strength and glucose regulation was assessed using multiple linear regression models.ResultsPrediabetes was diagnosed in 32.2% and diabetes in 8.4% using the OGTT. A total of 7.8% of the individuals had previously known diabetes. Compared to individuals with normoglycaemia, grip strength was lower for those with newly diagnosed diabetes (-1.8 kg, 95% CI -3.2 to -0.5) as well as those with previously known diabetes (-1.8 kg, 95% CI -3.2 to -0.4) after adjusting for covariates (age, sex, body mass index, physical activity, education and smoking). No difference in grip strength was found when comparing those with prediabetes and normoglycaemia.ConclusionIn adults, grip strength was lower among those with known and newly diagnosed diabetes compared to those with normoglycaemia. Together with previous findings on associations between grip strength and chronic diseases, these results support the use of grip strength as an overall health marker in adults.