电针对胰岛素抵抗肥胖大鼠能量调控信号瘦素的影响

目的:观察"标本配穴"电针对胰岛素抵抗肥胖大鼠能量调控信号瘦素(Leptin)及瘦素受体(OB-Rb)的影响,探究电针治疗肥胖可能存在的机制.方法:24只SPF级雄性Wistar大鼠随机分为正常组、模型组、电针组,每组8只.以高脂饮食建立胰岛素抵抗肥胖大鼠模型.电针组于"中脘""关元""足三里""丰隆"给予电针治疗,每...     

Radiation-initiated high strength chitosan/lithium sulfonate double network hydrogel/aerogel with porosity and stability for efficient CO2 capture

Developing efficient and inexpensive CO₂ capture technologies is a significant way to reduce carbon emissions. In this work, a novel chitosan/lithium sulfonate double network high strength hydrogel is synthesized by electron beam radiation. Due to the electron beam having a wide radiation area and certain penetrating power, the free radical polymerization can be initiated more uniformly and quickly in the hydrogel. The network structure of the hydrogel prepared by radiation-initiated polymerization is more uniform than that prepared by conventional chemical initiator-initiated polymerization. Meanwhile, the introduction of the second network to construct the double network structure does not reduce the surface area of the aerogel, which is different from the conventional method of grafting or impregnation modified porous materials. Moreover, the synthesized aerogels have good physical and chemical stability. The freeze-dried aerogels possess a porous structure and CO₂ capture ability due to the CO₂-philic double network structure. Because of the inexpensive raw material and convenient radiation process, this work can reduce the cost of CO₂ adsorbents and has prospects of application in the field of CO₂ solid adsorbents.

Chitosan hydrogel is regenerated from alkali/urea aqueous solution and the lithium sulfonate second network is introduced by electron beam radiation-initiated in situ free radical polymerization. The freeze-dried aerogel has CO₂ capture capacity.     

The effect of sleep impairment on gestational diabetes mellitus: a systematic review and meta-analysis of cohort studies

ObjectiveThis systematic review and meta-analysis evaluated the influence of sleep duration or impairment (poor sleep quality, snoring, and obstructive sleep apnea [OSA]) on gestational diabetes mellitus (GDM) risk.MethodsPubMed, Embase, EBSCO, and WOS databases were searched up to March 4th, 2019. Cohort studies were included and relative risk (RR) with 95% confidence interval (CI) were used as the measure of effects. Heterogeneity was assessed by the Chi-squared and I² tests. Subgroup analyses, sensitivity analysis, and dose-response analysis were performed. The overall quality of the evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.ResultsA total of 16 studies with 2,551,017 pregnant women and 142,103 GDM cases were included in this study. Both short and long sleep duration were associated with increased risk of GDM. There was a U-shaped relationship between sleep duration and GDM risk (P_{-nonlinearity} < 0.001), and pregnant women with 8 h of sleep presented lower GDM risk. Poor sleep quality, snoring and OSA also increased the subsequent risk of GDM.ConclusionsPregnant women should be made aware of the benefits of proper sleep, and those with poor sleep quality, snoring, and OSA should be screened for GDM.     

A Broad Learning System with Ensemble and Classification Methods for Multi-step-ahead Wind Speed Prediction

Cognitive Computation - Short-term wind speed prediction plays a significant role in the management of large-scale wind power plants. However, wind speed prediction is extremely complex and...     

温胆汤方剂对睡眠剥夺小鼠氧化应激及炎症反应的影响

目的:研究温胆汤对睡眠剥夺小鼠的改善作用以及对小鼠氧化应激和炎症水平的影响.方法:将30只SPF级昆明雌性小鼠随机分为5组:对照组、模型组、温胆汤低浓度组(含生药0.5 g/ml)、温胆汤高浓度组(含生药2 g/ml)和艾司唑仑片组(0.15 mg/kg),每组6只.采用改良版水平转盘睡眠剥夺法构建失眠小鼠模型,记录小...     

基于因子分析法的超声肝灌注定量分析初步研究

局灶性肝结节(FLLs)通常可从超声造影图像序列中提取的时间强度曲线进行量化评价.为了克服人工选择的主观性并自动提取曲线,提出一种用于因子分析的基于顶点搜寻的替代-近似(RA)算法.该算法将高维图像序列映射到一维空间,先找到与生理结构对应的两个顶点.然后,根据这两个已知点的信息,在二维空间中可以寻找到第3个顶点.这3个顶点对应着3条不同的目标曲线.实验采用6个在患者自由呼吸运动下采集的肝细胞癌病例对RA算法进行验证.实验结果表明,此方法能准确提取到具有生理意义的因子曲线和相应的因子图,提取的因子曲线与感兴趣区域(ROI)测定曲线的平均相关系数值为0.91±0.03.初步证明了RA算法在FLLs灌注的量化分析具有可行性.