大学生网络成瘾类型问卷的初步编制

目的:编制适用我国大学生的网络成瘾类型问卷。方法:根据访谈、开放式问卷施测结果,编制大学生网络成瘾类型问卷;调查样本为733名武汉地区大学生,91名大学生作为重测样本;检验了问卷的同质信度、重测信度、结构效度等。结果:探索性因素分析获得3个因素,即网络游戏成瘾、网络人际关系成瘾及网络信息成瘾,各因子负荷在0·50~0·82之间。总问卷及各分问卷的同质性信度(Cronbachα)、分半信度及重测信度分别为0·80~0·92、0·79~0·90和0·81~0·91。验证性因素分析结果表明问卷的三因素模型各项参数(RMSEA=0·07,CFI=0·98,NFI=0·97,IFI=0·98,TLI=0·97,RFI=0·96)均达到可以接受的水平。结论:该问卷具有较好的信度和效度,可用于大学生网络成瘾类型的测试。     

Computer analysis system of blood oxygen saturation in an animal hypoxia model

An experimental animal hypoxia model has been developed. It consists of two sensors (an in vitro and in vivo model), an experimental device and a computer signal processing system. This method can easily be applied to determine and analyse blood oxygen saturation at various hypoxia levels. It can also be used to evaluate the accuracy of pulse oximetry over a wide range of oxyhemoglobin desaturation levels. The DC and AC components of recorded red and infra-red signals, the dual-wavelength ratio R₁₂ and the reading of a pulse oximeter (SpO₂) can be automatically calculated and displayed on a computer screen. Preliminary results of the animal hypoxia test indicate that the measurements made by the instrument correlate well with the oxygen saturation readings of the automatic blood gas analyser AVL945. The computer analysis system is suitable for repeated estimations in the animal model.     

Fast MR Spectroscopic Imaging Technologies and Data Reconstruction Methods

MRSI plays a more and more important role in clinical application. In this paper, we compare several fast MRSI technologies and data reconstruction methods. For the conventional phase encoding MRSI, the data reconstruction using FFT is simple. But the data acquisition is very time consuming and thus prohibitive in clinical settings. Up to now, the MRSI technologies based on echo-planar, spiral trajectories and sensitivity encoding are the fastest in data acquisition, but their data reconstruction is complex. EPSI reconstruction uses shift of odd and even echoes. Spiral SI uses gridding FFT. SENSE-SI, a new approach to reducing the acquisition time, uses the distinct spatial sensitivities of the individual coil elements to recover the missing encoding information. These improvements in data acquisition and image reconstruction provide a potential value of metabolic imaging as a clinical tool.     

基于互信息的医学图像配准实验

基于互信息的配准方法，包括互信息和归一化互信息方法，是目前医学图像配准中无创、自动且精度很高的一种方法。已经被广泛应用。但是在其目标函数中存在着一定程度的幅值振荡现象。特别是在单模态图像配准中。我们研究发现，产生这种振荡的原因除了插值赝像外，还有由配准过程中图像重叠部分发生变化而引起的熵的变化不确定性。由插值赝像所带来的振荡基本上可以被消除掉；由熵的变化不确定性所带来的振荡很难被消除，但是这种振荡作用在归一化互信息中影响不大。归一化互信息比互信息具有更高的稳健性，适合于更广的应用范围。     

“双一流”高校工科学报校内发文量与学术影响力统计分析

【目的】 研究“双一流”高校工科学报校内发文量与学术影响力间的关系,探讨学报发挥自身优势,提升期刊学术质量,继续推动高校和学科建设的策略。【方法】 依据中国知网期刊数据库及《中国科技期刊引证报告(核心版)》统计24种“双一流”高校工科学报2012年、2014年、2016年和2018年的校内发文量、影响因子、被引频次、基金论文比、综合排名,辅以EI收录期刊、“中国科技期刊卓越行动计划”入选期刊的情况。【结果】 有18种高校学报的校内发文比例较高,具有较强的内向性;大部分学报的校内发文比例呈下降或波动稳定趋势,开放办刊的同时也流失了部分校内优质稿件;基金论文比普遍较高;23种学报的影响因子在0.5上下波动,特色优势不明显。由此可见,校内发文比例不直接决定学报的学术影响力,更为重要的是要积极拓展稿源,提升论文质量。【结论】 “双一流”高校工科学报需要依托高校优势学科,设定特色栏目吸引特色论文;挖掘本校学者资源,提升校内发文质量;坚持科学评价导向,让高校涌现的高水平成果落地生根,推进大学各学科发展,共创一流。     

人工神经网络预滤波的自适应运动心电信号增强器

运动心电图是一种将人体对象置于非平静状态下检测到的心电信号，其特点是运动导致基线严重漂移，肌电干扰显著增加，信噪比低。介绍了一种用人工神经网络预滤波的自适应运动心电信号增强器。运用人工神经网络的非线性和自适应处理的跟踪特性有机地结合设计而成。能降低噪声，提高信噪比，有效地提取运动心电信号。     

Cd4+ T cell apoptosis induced by anti-CD4 antibodies

Summary To explore the inhibitory effects of anti-CD4 human/murine chimeric antibodies on lymphocyte proliferation, CD4⁺ T cell apoptosis induced by anti-CD4 antibodies was examined. Annexin-V-FITC and PI double stain method was employed to qualitatively and quantitatively determined CD4⁺ T cell apoptosis induced by anti-CD4 antibodies. Our results showed that anti-CD4 chimeric antibodies could specifically induce CD4⁺ T cell apoptosis. The ability of anti-CD4 chimeric antibodies to induce CD4⁺ T cell apoptosis was related with the presence of monocytes. It is concluded that the further cross-linking of anti-CD4 antibodies is important for inducing CD4⁺ T cell apoptosis. This project was supported by grant from the National Sciences Foundation of China (No. 39370628).     

21纪我国医药行业的创新与发展

在分析我国医药行业发展现状及存在问题的基础上,研究了加入WTO后医药行业所面临的机遇与挑战,以及当前医药企业技术创新存在的不足,提出了21世纪我国医药行业创新与发展的对策和建议。