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排序方式: 共有658条查询结果,搜索用时 31 毫秒
51.
Elisa Pianigiani M.D. Giovambattista De Aloe M.D. rea Andreassi M.D. Pietro Rubegni M.D. & Michele Fimiani M.D. 《Pediatric dermatology》2001,18(5):422-425
Rothmund-Thomson syndrome (RTS) is a genetic disease characterized by developmental abnormalities and poikilodermatous skin changes that appear in infancy. An association with myelodysplastic syndromes is rarely reported in RTS, even though impairment of immune function and recurrent infections are described in the literature. A case of Thomson-type RTS in a 14-year-old girl with trilinear myelodysplasia is presented. The patient was kept under hematologic surveillance for myelodysplastic syndrome. Bone marrow transplantation was considered unnecessary at present. 相似文献
52.
José G. Dórea 《Environmental research》2009,109(1):131-132
The co-occurrence of fish MeHg and omega-3 fatty acids in wild species can indeed be optimized by choosing certain species. Farmed finfish and shellfish that are fed fish-meal, however, can bioconcentrate both MeHg (in muscle) and organohalogen pollutants passed on in the fat components [Dorea, J.G., 2006. Fish meal in animal feed and human exposure to persistent bioaccumulative and toxic substances. J. Food Prot. 69, 2777-2785); when fish-meal is used to feed farm animals it may offer the worst of both worlds: saturated fat (with organohalogen pollutants) and MeHg. It is time to address the dietary sources of Hg derived from animals raised on fish-meal that may contribute to increase tissue Hg concentrations. 相似文献
53.
Roberto BalagnaMD Delia AbboMD Federica FerreroMD rea ValoriMD Licia Peruzzi 《Paediatric anaesthesia》1999,9(4):342-344
We report a case of severe accidental hypothermia (24.8 degrees C) in a seven-year-old child due to prolonged exposure to low temperatures and temporary contact with river water. When the patient was seen in hospital, bradycardia (30.min-1), bradypnoea (5. min-1), scarcely reacting pupils, and Glasgow Coma Scale=3 were noted. For rewarming minimally invasive techniques (humidified warmed gases and intravenous solutions at 40 degrees C) were employed with a very successful outcome. 相似文献
54.
Maria Amélia A. Estrela Jurandir R. SouzaDe Sílvia C. L. Dias José G. Dórea 《Bulletin of environmental contamination and toxicology》2010,84(5):574-576
Determination of chlorine ions of pesticides was performed after dechlorination reaction using a palladium/magnesium system.
Chlorine ions were quantified by potentiometry with ion-specific electrode. Rates of dechlorination of 100 μg of DDT as a
function of reaction time and percent (wt/wt) of palladium deposited on the magnesium particles were determined. The best
reaction conditions to DDT dechlorination were achieved with an acetone/water (1:1) solution and DDT reaction with a 0.27%
(wt/wt) palladium/magnesium bimetallic system at room temperature for 10 min. The detection limit was of 0.24 μg/mL. This
low cost method showed an efficiency of 92% in determining chlorine ions derived from DDT, it is fast, requiring no specialized
laboratory equipment. 相似文献
55.
Paivi M.H. Miettunen M.D. § ¶ rea Bruecks M.D. † ¶ Todd Remington M.D. ‡ ¶ 《Pediatric dermatology》2009,26(3):338-341
Abstract: Discoid lupus erythematosus (DLE) is rare in childhood. We report the case of a 5-year-old girl who presented with erythematous scaly plaques, with scarring alopecia, involving approximately 40% of her scalp. Histopathology confirmed the diagnosis of DLE. Treatment with intravenous methylprednisolone, hydroxychloroquine, oral prednisone, topical corticosteroids, and sunscreen lead to reversal of scarring alopecia and re-growth of hair. 相似文献
56.
Anita Sebastian Connor Patterson rea L. Zaenglein Michael D. Ioffreda Klaus F. Helm 《Journal of cutaneous pathology》2009,36(12):1323-1325
Erythema multiforme is histologically characterized by liquefactive degeneration along the dermal-epidermal junction, necrotic keratinocytes and a lymphocytic infiltrate. We report a 10-year-old boy with recurrent erythema multiforme major of undetermined etiology with unusual histologic findings. A skin biopsy taken at day 2 of his eruption revealed histologic features otherwise characteristic of erythema multiforme, but mediated instead by a CD68-positive infiltrate, resembling cutaneous Kikuchi's disease. To the best of our knowledge this is the first reported case of 'histiocytic' erythema multiforme. 相似文献
57.
Luca Pierelli Alessandro Perillo Gabriella Ferrandina Giovanna Salerno Sergio Rutella rea Fattorossi Alessandra Battaglia Aurelia Rughetti Marianna Nuti Enrico Cortesi Giuseppe Leone Salvatore Mancuso Giovanni Scambia 《Transfusion》2001,41(12):1577-1585
BACKGROUND: Peripheral blood progenitor cell (PBPC) transplantation (PBPCT) combined with post-PBPCT administration of myelopoietic growth factors is a valid therapeutic intervention to rapidly restore hematopoiesis after the delivery of intensive, myeloablative cancer chemotherapy. On the other hand, the best growth factor regimen to potentiate PBPC-mediated immunohematopoietic recovery has yet to be determined. STUDY DESIGN AND METHODS: In a randomized evaluation, the effects produced by post-PBPCT G-CSF and GM-CSF on myeloid/lymphoid recovery and transplant outcome in women with chemosensitive cancer were compared. Thirty-seven ovarian cancer patients and 34 breast cancer patients ranging in age from 24 to 60 years were treated with carboplatin, etoposide, and melphalan (CEM) high-dose chemotherapy and then randomly assigned to receive G-CSF (5 microg/kg subcutaneously) or GM-CSF (5 microg/kg subcutaneously) until Day 13 after PBPCT. Patients were compared in regard to hematopoietic recovery, posttransplant clinical management, and immune recovery. Finally, clinical outcome was estimated as time to progression and overall survival. RESULTS: Hematopoietic recovery and posttransplant clinical management were comparable in both the G-CSF and GM-CSF series. Conversely, significantly higher T-cell counts were observed in G-CSF-treated patients during the early and late posttransplant follow-up. Patients who received G-CSF showed a significantly longer median time to progression. A parallel analysis revealed that patients in whom a higher CD3+ count was recovered had a significantly longer overall survival and time to progression. CONCLUSION: The enhancement of post-PBPCT T-cell recovery observed in G-CSF-treated patients encourages the use of G-CSF to ameliorate immune recovery, which seems to play a role in post-PBPCT control of disease in cancer patients. GM-CSF might be administered to prolong immunosuppression after autologous PBPCT for autoimmune diseases or allogeneic PBPCT. 相似文献
58.
Păltineanu B Bacârea V 《Revista medico-chirurgical?? a Societ????ii de Medici ??i Naturali??ti din Ia??i》2010,114(4):1142-1147
Due to the fact that in Romania there are two health systems, public and private, some questions have been raised regarding the efficiency of a certain system, taking into account the quality but also the costs of provided services. Material and method: The study compares the costs of laparoscopic surgical techniques, analysing the causes of the differences that were found, if that were some advantages offered by one of the system to another and if there is a possibility of complementarity perspective between those two medical assistance organisation methods. 相似文献
59.
Martin Reichel Elisabeth Greiner Tanja Richter-Schmidinger Özlem Yedibela Philipp Tripal rea Jacobi Stefan Bleich Erich Gulbins Johannes Kornhuber 《Alcoholism, clinical and experimental research》2010,34(1):46-50
Background: Acid sphingomyelinase (ASM; EC 3.1.4.12) hydrolyses membrane sphingomyelin into the bioactive lipid ceramide and is thus involved in different cellular processes such as differentiation, immunity, or cell death. Activation of ASM has been reported in particular in conjunction with the cellular stress response to several external stimuli, and increased ASM activity was observed in a variety of human diseases. Ethanol-induced activation of ASM has been observed in different cell culture systems, thus raising the question about the effect of alcohol intoxication in human subjects on ASM activity in vivo.
Methods: We determined ASM activity in peripheral blood mononucleated cells of 27 patients suffering from alcohol dependence. Patients were classified according to their blood alcohol concentration at admission, and ASM activity was determined repeatedly from all patients during alcohol withdrawal.
Results: Acutely intoxicated patients displayed significantly higher ASM activity than patients in early abstinence (Mann–Whitney U test: Z = − 2.6, p = 0.009). ASM activity declined in acutely intoxicated patients to normal values with the transition from the intoxicated state to early abstinence (Wilcoxon test: Z = −2.7, p = 0.007). At the end of withdrawal, ASM activity was significantly increased again compared to the early phase of abstinence in both patient groups (Wilcoxon test: Z = −2.691, p = 0.007 and Z = −2.275, p = 0.023, respectively).
Conclusions: Alcohol-induced activation of ASM occurs in human subjects and might be responsible for deleterious effects of ethanol intoxication. Chronic alcohol abuse may induce deregulation of sphingomyelin metabolism in general, and this impairment may cause side effects during withdrawal from alcohol. 相似文献
Methods: We determined ASM activity in peripheral blood mononucleated cells of 27 patients suffering from alcohol dependence. Patients were classified according to their blood alcohol concentration at admission, and ASM activity was determined repeatedly from all patients during alcohol withdrawal.
Results: Acutely intoxicated patients displayed significantly higher ASM activity than patients in early abstinence (Mann–Whitney U test: Z = − 2.6, p = 0.009). ASM activity declined in acutely intoxicated patients to normal values with the transition from the intoxicated state to early abstinence (Wilcoxon test: Z = −2.7, p = 0.007). At the end of withdrawal, ASM activity was significantly increased again compared to the early phase of abstinence in both patient groups (Wilcoxon test: Z = −2.691, p = 0.007 and Z = −2.275, p = 0.023, respectively).
Conclusions: Alcohol-induced activation of ASM occurs in human subjects and might be responsible for deleterious effects of ethanol intoxication. Chronic alcohol abuse may induce deregulation of sphingomyelin metabolism in general, and this impairment may cause side effects during withdrawal from alcohol. 相似文献
60.
Dórea JG 《Toxicology letters》2012,210(2):264; author reply 265-264; author reply 266