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Miguel ngel Gonzlez-Moles Saman Warnakulasuriya Isabel Gonzlez-Ruiz ngela Ayn Lucía Gonzlez-Ruiz Isabel Ruiz-vila Pablo Ramos-García 《Medicina oral, patología oral y cirugía bucal》2021,26(4):e541
Background Patients with oral lichen planus (OLP) have an increased risk of oral cancer. For this reason, OLP is classified as an oral potentially malignant disorder. However, the precise personal (or individual) risk is unknown. Recent meta-analytical studies have reported that dysplastic OLP may transform to cancer in around 6% of cases, while the rate of transformation is lower (<1.5%) in non-dysplastic cases. The presence of epithelial dysplasia has emerged as the most powerful indicator for assessing cancer risk in oral potentially malignant disorders in routine practice. However, the general acceptance of epithelial dysplasia as an accompanying histologic feature in OLP is subject to great controversy. Many pathologists consider the presence of dysplasia as a criterion to exclude OLP when routinely reporting on this disease. This practice, widespread among oral pathology professionals, has resulted in the underestimation of the potential for malignancy of OLP.Material and Methods A review of the literature was carried out in order to critically analyze the relevance, controversies and challenges encountered across the diagnosis of epithelial dysplasia in OLP.Results 12 studies have been published examining dysplastic changes in OLP, reporting Figures ranging from 0.54% to 25% of cases with dysplasia in the first diagnostic biopsy. The diagnosis of dysplasia in the OLP poses an additional difficulty due to the fact that the affected oral epithelium per se develops changes related to autoimmune aggression. Among the most frequent histological features of OLP that develops dysplasia are basal cell hyperplasia with basaloid appearance, loss of basal cells polarity, cellular and nuclear pleomorphism and irregular stratification.Conclusions Epithelial dysplasia should not be considered an exclusion criterion for OLP; its evaluation requires experienced pathologists in this field. Key words:Oral lichen planus, epithelial dysplasia, oral cancer. 相似文献
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Díez-Villalba R González-Ruiz M Izquierdo-Vázquez C Molina-Quirós C Colmenero-Ruiz M Ramos-Amador A Jordano-Luna L Mora-de-Oñate J Sanz-Fernández R 《Archivos de la Sociedad Espa?ola de Oftalmología》2008,83(5):317-320
PURPOSE/METHOD: To report the ophthalmologic presentation of two cases of esthesioneuroblastoma (ENB). A comprehensive ophthalmic assessment was made, including magnetic resonance imaging. A paranasal sinus mass was biopsied in one case and a nasal mass biopsied in the other. CASES REPORT/DISCUSSION: Two women, aged 85 and 32 years respectively, presented to the emergency room with ophthalmic symptoms and signs. The first reported orbital pain and eyelid edema and the second, who was 22 weeks pregnant, reported a spontaneous lower eyelid haematoma, orbital pain and rhinorrhoea. ENB is a rare malignant tumour and its presentation with ophthalmologic symptoms and signs is very infrequent. 相似文献
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José María González-Ruiz Msc María Isabel Pérez-Núñez PhD Mª Dolores García-Alfaro PhD Markus Bastir PhD 《Journal of anatomy》2021,239(6):1400-1408
Fluctuating asymmetry (FA) is an indicator of developmental instability referred to random deviations from mean asymmetry. That average asymmetry is the directional asymmetry (DA), which, in the particular case of adolescent idiopathic scoliosis (AIS), corresponds to a right thoracic and left lumbar curves. Investigating the presence of FA and DA in AIS has never been done, and it is a key element of the pathophysiology of the scoliotic condition. Thirty-six X-rays of patients with AIS were digitized and analysed using Geometric Morphometric analyses to test for both statistical effects. The individual FA score for each patient was calculated using Procrustes ANOVA and a methodology based on the components of shape was used to estimate the individual DA score. DA is a stronger effect than FA (2.12 to 1), as it has been found in other clinical conditions. The individual DA score, with an effect size of 0.58, is a better predictor of the Cobb angle than FA score. The methodology presented in this paper to estimate DA score is a valid approach in the study of asymmetries in AIS. FA should be correlated in future studies with environmental covariates to serve as a variable in the medical prognosis, while DA will serve as a good predictor of the Cobb angle during the course of the condition, avoiding the abuse of X-rays. This potential use of DA should be tested on 3D shape due to the three-dimensional clinical presentation of AIS. 相似文献
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