全文获取类型
收费全文 | 22689篇 |
免费 | 2165篇 |
国内免费 | 662篇 |
专业分类
耳鼻咽喉 | 223篇 |
儿科学 | 424篇 |
妇产科学 | 736篇 |
基础医学 | 2751篇 |
口腔科学 | 487篇 |
临床医学 | 2336篇 |
内科学 | 3897篇 |
皮肤病学 | 502篇 |
神经病学 | 1479篇 |
特种医学 | 832篇 |
外国民族医学 | 11篇 |
外科学 | 2916篇 |
综合类 | 2283篇 |
现状与发展 | 3篇 |
一般理论 | 4篇 |
预防医学 | 1349篇 |
眼科学 | 564篇 |
药学 | 2108篇 |
15篇 | |
中国医学 | 783篇 |
肿瘤学 | 1813篇 |
出版年
2024年 | 38篇 |
2023年 | 260篇 |
2022年 | 396篇 |
2021年 | 878篇 |
2020年 | 682篇 |
2019年 | 728篇 |
2018年 | 762篇 |
2017年 | 628篇 |
2016年 | 642篇 |
2015年 | 884篇 |
2014年 | 1064篇 |
2013年 | 1230篇 |
2012年 | 1723篇 |
2011年 | 1741篇 |
2010年 | 1237篇 |
2009年 | 963篇 |
2008年 | 1273篇 |
2007年 | 1314篇 |
2006年 | 1265篇 |
2005年 | 1085篇 |
2004年 | 1023篇 |
2003年 | 985篇 |
2002年 | 880篇 |
2001年 | 679篇 |
2000年 | 528篇 |
1999年 | 402篇 |
1998年 | 179篇 |
1997年 | 167篇 |
1996年 | 126篇 |
1995年 | 116篇 |
1994年 | 118篇 |
1993年 | 92篇 |
1992年 | 201篇 |
1991年 | 147篇 |
1990年 | 149篇 |
1989年 | 100篇 |
1988年 | 88篇 |
1987年 | 88篇 |
1986年 | 59篇 |
1985年 | 66篇 |
1984年 | 63篇 |
1983年 | 38篇 |
1982年 | 43篇 |
1980年 | 25篇 |
1979年 | 38篇 |
1978年 | 25篇 |
1975年 | 31篇 |
1974年 | 30篇 |
1973年 | 26篇 |
1972年 | 29篇 |
排序方式: 共有10000条查询结果,搜索用时 62 毫秒
91.
目的 利用诱发电位技术探讨正常人听觉P50特征.方法 应用美国Nicolet Bravo脑电生理仪,采用条件刺激(S1)-测试刺激(S2)模式对45名健康受试者作了听觉P50检测.结果 分析了基本波型,提出了Cz和Pz区域P50诸指标平均值.结论 听觉P50电位具有抑制性特征,其变化可反映大脑正常感觉门的功能状态.P50较佳表达式是波幅S1-S2和100(1-S2/S1)两种结合,能直接显示感觉门的程度.此正常值可供抑郁症研究时参考. 相似文献
92.
Huei-Shyong Wang M.D. Meng-Fai Kuo M.D. Song-Chei Huang M.D. 《Developmental medicine and child neurology》1992,34(10):911-915
The brainstem abscess of a nine-year-old girl with tetralogy of Fallot was cured after six weeks of parenteral antibiotic therapy, without surgical intervention. Serial studies of brainstem auditory evoked potentials were undertaken until the patient was clinically normal. To the authors' knowledge, this is only the second medically cured case reported in the literature, and it is the first case studied with serial brainstem auditory evoked potentials. If the clinical status allows, medical treatment of a brainstem abscess with appropriate antibiotics could be tried before surgical intervention such as stereotactic aspiration for reducing the mass. 相似文献
93.
Reversal of fulminant hepatic failure using an extracorporeal liver assist device. 总被引:20,自引:0,他引:20
N L Sussman M G Chong T Koussayer D E He T A Shang H H Whisennand J H Kelly 《Hepatology (Baltimore, Md.)》1992,16(1):60-65
Liver transplantation is currently the only effective therapy for patients with fulminant hepatic failure. The availability of an artificial liver could bridge these patients through the relatively brief crisis period and allow their own livers to regenerate, providing a more favorable outcome and sparing the trauma and expense of transplant. We have developed a device consisting of a highly differentiated human liver cell line cultured in a hollow fiber cartridge. This device is capable of supporting dogs with acetaminophen-induced fulminant hepatic failure for a period long enough for their own livers to resume function. Even though liver function tests such as albumin and prothrombin time became extremely abnormal during the course of the experiment, the dogs did not become encephalopathic. Two of the three treated animals recovered sufficient liver function after 42 to 48 hr of treatment that they could be disconnected from the device, and they survived the experiment. Histological results and serum ALT levels suggest that the device affected the course of the disease in two animals, allowing recovery of hepatocytes that would otherwise have lysed. In the third animal, regenerative nodules demonstrated that, even in the presence of severe liver injury, the device was capable of supporting total liver function. 相似文献
94.
C Y Chai W C Wu S Wang C K Su Y F Lin C T Yen J S Kuo M J Wayner 《Brain research bulletin》1992,29(1):15-26
The effects of electrical stimulation and microinjection of sodium glutamate (0.5 M) in the sympathetic pressor areas of the dorsal medulla (DM), ventrolateral medulla (VLM), and parvocellular nucleus (PVC) on the knee jerk, crossed extension, and evoked potential of the L5 ventral root produced by intermittent electrical stimulation were studied in 98 adult cats anesthetized with chloralose and urethane. During electrical and glutamate stimulation of these pressor areas, in addition to the rise of systemic arterial blood pressure marked inhibition of the spinal reflex was produced, indicating presence of neuronal perikarya responsible for these actions. Mild to moderate augmentation of spinal reflexes was also observed during brain stimulation but only in a few cases. The magnitude of the somatic effects among the pressor areas of the VLM, DM, and PVC subsequent to glutamate activation was about the same. Induced spinal reflex inhibition, independent from the baroreceptor and vagal influence, remained essentially unaltered after acute midcollicular decerebration. The inhibition was also observed in cats decerebellated 8-10 days in advance. The inhibition was not affected after bilateral electrolytic- or kainic-acid-induced lesions in the paramedian reticular nucleus (PRN). On the contrary, PRN-induced spinal reflex inhibition was attenuated after bilateral lesions in the DM or VLM. Data suggest that there coexists neuronal subpopulations in the VLM, DM, and PVC that can affect both the sympathetic pressor systems and spinal reflexes. 相似文献
95.
96.
97.
Mun Su Kang Dong Il Park Jung Ho Park Hong Joo Kim Yong Kyun Cho Chong Il Sohn Woo Kyu Jeon Byung Ik Kim 《Taehan Sohwagi Hakhoe chi》2006,48(6):395-400
BACKGROUND/AIMS: Bamboo joint-like (BJL) appearance is an endoscopic finding characterized by swollen longitudinal folds transversed by erosive fissures or linear furrows on the lesser curvature side of gastric body and cardia. It has been reported to be associated with Crohn's disease (CD). This study was aimed to evaluate the incidence of BJL appearance in Korean patients with CD. METHODS: From January to December in 2005, we performed esophagogastroduodenoscopy (EGD) in patients diagnosed as CD and ulcerative colitis (UC) in our hospital. Non-inflammatory bowel disease (IBD) subjects with upper gastrointestinal symptoms who underwent EGD were consecutively enrolled during the same period. One endoscopist performed all the endoscopic examinations to avoid inter-observer variation. A dye-spraying technique with 0.4% indigocarmine was used to allow the detection of subtle changes during the endoscopic examination. RESULTS: A total of 21 patients with CD (mean age+/-SD, 40+/-15 yr; M/F, 13/8), 28 patients with UC (42+/-15 yr; 21/7), and 685 non-IBD subjects (49+/-14 yr; 354/331) were enrolled. EGD findings in CD patients were gastric erosions (11/21), chronic superficial gastritis (5/21), chronic atrophic gastritis (1/21), duodenal erosions or ulcers (2/21), and normal (2/21). Incidence of BJL appearance was significantly higher in patients with CD (47.6%, 10/21) than others (UC, 3.6%, 1/28; non-IBD, 0.1%, 1/685) (p< 0.0001). Among patients with CD, incidence of BJL appearance was not significantly different according to the sex, status of H. pylori infection, Vienna classification for phenotype, medications or EGD findings. CONCLUSIONS: BJL appearance on the gastric body and cardia can be a diagnostic clue to CD. 相似文献
98.
异丙酚及氯胺酮靶控输注全静脉麻醉临床应用 总被引:4,自引:1,他引:3
目的 研究异丙酚复合不同镇痛剂量氯胺酮靶控输注全静脉麻醉临床应用的可行性及对血流动力学、麻醉恢复的影响。方法 择期手术患者 80例 ,分别采用异丙酚 (P组 ,n =16)及复合氯胺酮血药浓度 0 2 0mg/L(PK1组 ,n =16) ,0 40mg/L(PK2 组 ,n =16) ,0 60mg/L(PK3 组 ,n =16)和 0 80mg/L(PK4组 ,n =16)全静脉麻醉 ,采用微机控制Graseby 3 5 0 0输液泵靶控输注异丙酚或氯胺酮 ,连接Aspect-A10 0 0型脑电监护仪监测脑电变化 ,观察两组患者血流动力学改变及麻醉恢复情况。结果 单用异丙酚患者随着异丙酚血药浓度升高脑电双频指数 (BIS)值降低 ,呈明显负相关 (P <0 0 5 ) ,氯胺酮血药浓度从 0 2 0mg/L增至 0 80mg/L ,BIS值无明显变化 (P >0 0 5 )。与P组相比 ,PK1,PK2 ,PK3 ,PK4组异丙酚用量减少约 15 %~ 40 % ,PK4组停药至睁眼时间明显延长 ,其余各组无明显差异 (P >0 0 5 )。术中P ,PK1组收缩压、舒张压升高 ,PK2 ,PK3 ,PK4组无明显改变。术后无躁动、不良回忆等并发症。结论 异丙酚复合镇痛剂量的氯胺酮 (0 40~ 0 60mg/L)靶控输注全静脉麻醉具有血流动力学稳定、减少异丙酚用量、无明显术后并发症等优点。 相似文献
99.
所谓社区康复的“社区”一词尚没有明确的定义。其范围是小的群体、大城市、县,也有以国为单位的。另方面,关于康复历史上虽提出了很多概念,但现在暂时一致采用1982年“联合国残疾人世界行动计划”的定义,即康复是尽可能使躯体和心理达到社会的最适机能水平,旨在提供改变个体人生的手段,且限定在一定时间的过程。但与康复的4个方面,即依据医学、社会、职业、教育的专门领域的概念相异,统一还相当困难。 相似文献
100.
Dr. Steven A. Curley MD Robert A. Newman PhD Thomas B. Dougherty MD PhD George M. Fuhrman MD Diana L. Stone BS Jeffrey A. Mikolajek CRNA Sal Guercio CCP Ann Guercio CCP C. Humberto Carrasco MD M. Tien Kuo PhD David C. Hohn MD 《Annals of surgical oncology》1994,1(5):389-399
Background: We performed a phase I study of a novel system of complete hepatic venous isolation and extracorporeal chemofiltration in
patients with unresectable hepatocellular carcinoma (HCC) to determine (a) whether systemic exposure to doxorubicin could
be limited after high-dose hepatic arterial infusion (HAI), and (b) the hepatic maximum tolerated dose (MTD) of doxorubicin.
Methods: Ten patients with biopsy-proven HCC were treated with 20-min HAI of doxorubicin (17 total treatments). Two patients were
treated with doxorubicin 60 mg/m2, three patients were treated at 90 mg/m2, and five patients received 120 mg/m2. A newly developed dual-balloon vena cava catheter was advanced from the femoral vein, and the balloons were inflated to
isolate and capture total hepatic venous outflow. The hepatic venous blood was pumped through extracorporeal carbon chemofilters
before return of the blood to the systemic circulation.
Results: Peak systemic doxorubicin levels were an average 85.6% lower than were peak prefilter levels (p<0.01). Because all catheters
were placed percutaneously and because the chemofiltration markedly limited systemic chemotherapy exposure, patients were
discharged 1 day after 16 of the 17 treatments. The hepatic and systemic MTD of doxorubicin in this treatment protocol was
120 mg/m2.
Conclusions: This novel system of complete hepatic venous isolation and chemofiltration limits systemic chemotherapy toxicity and will
allow use of higher doses of chemotherapeutic agents to treat HCC.
The results of this study were presented at the 46th Annual Cancer Symposium of The Society of Surgical Oncology, Los Angeles,
California, March 18–21, 1993. 相似文献