新化合物 A-失碳-17β-羟基-17α-乙炔基-Δ3(5),9(10)-雌甾二烯-2-酮的合成

报道新化合物A-失碳-17β-羟基-17α-乙炔基-Δ^3(5),9(10)-雌甾二烯-2-酮2的合成。文中探讨了用炔钾粗品对A-失碳-Δ^3(5),9(10)-雌甾二烯-2，17-二酮１和Ａ-失碳-６β，１９-环氧-Δ³-雄甾-2，17-二酮3的选择性炔化，分别得标题化合物2（44%）及Ａ-失碳-17β-羟基-17α-乙炔基-６β，１９-环氧-Δ³雄甾-2-酮４（６５％），４经还原性破开环氧、去羟甲基和去醋酰氧基合成了标题化合物２。四步总收率为３４％。     

药用胶带纸层厚度检测系统

设计并试制了一种药用胶带纸层厚度在线检测系统．该系统将高精度电容传感器与计算机结合起来，同时配有丰富的外围器件，实现了多种实际生产中所需要的功能．它的出现，彻底解决了药用胶带纸胶层厚度在线检测这个难题，经过两年多的实际应用的检验，该系统实现了在线非接触测量，精度高，动态性能好，实现功能全面，价格合理，是药用胶带纸生产的必备检测仪器．由于该系统还可以很方便在纸张、塑料薄膜等其它生产线上进行推广，因而，其应用前景十分看好．     

植物营养活力素对小鼠生长及耐受能力的影响

以不同剂量的植物营养活力素（ＰＶＮ）喂饲小鼠，对小鼠的体重增长、耐寒、耐热、耐力等进行了观测。结果：用药后实验小鼠的体重和胸脾系数明显增加；耐寒、耐热及持续游泳时间明显延长。表明ＰＶＮ可明显提高小鼠的体重增长和对应激的耐受能力，提示其营养作用不仅适用于植物，而且适用于动物。     

A Decade of Change in Obesity Surgery

Background: The International (formerly National) Bariatric Surgery Registry began collecting data in January 1986. The aim of this study was to examine changes in the practice of surgical treatment of severe obesity that occurred during the decade of 1986 through 1995, as observed in the IBSR data. Methods: All data submitted to the IBSR during the decade were transferred to the IBM mainframe computer for analysis. Characteristics of operative type populations were compared over time using analysis of variance (ANOVA) for age, body mass index (BMI), operative weight and Chi-square (χ²) test for gender. Results: There has been a steady increase over the decade in mean patient weight. The operations used have changed from predominantly ‘simple’ operations to more frequent use of ‘complex’ operations. Within the categories of ‘simple’ and ‘complex’, an increase in the variety of operations occurred. As a group, patients with ‘simple’ operations have been heavier, more often male and public pay patients than those who have undergone ‘complex’ operations. One year weight loss was greater for Roux-en-Y gastric bypass (RGB) than vertical banded gastroplasty (VBG), but follow-up rates were too low to study the relative merits of the operations used. The reported incidence of operative mortality and serious complications (leak with peritonitis, abscess and pulmonary embolism) remained low. Conclusions: These observations and their implications can be summarized in three statements which relate to action for improved patient care in the beginning of the new century: (1) increasing weight of candidates for surgical treatment during this decade indicates the need for earlier use of operative treatment before irreversible complications of obesity can develop; (2) low risk of obesity surgery, decreasing postoperative hospital stay, and early weight control support the continued and increased use of surgical treatment; (3) continued widespread use of both ‘simple’ and ‘complex’ operations with increased modifications of standard RGB and VBG procedures emphasizes the need for standardized long-term data and analyses regarding both weight control and postoperative side-effects.     

银汞充填体悬突的去除及效果的临床观察

本文选择34颗有银汞充填体悬突的患牙,采用金刚砂钻和银汞磨光钻去除悬突,并观察去除悬突前后部分牙周组织的变化、结果表明银汞充填体悬突危害牙周组织的健康.去除悬突并协同口腔卫生宣教、可促进牙周组织的恢复.     

前路器械内固定手术矫治脊椎侧凸

作者从１９７９年开始使用戴瓦氏手术，１９８３年开始使用斯伍基氏手术，至１９９４年共做５７例（男性２８例，女性２９例），年龄为９～２８岁。手术无死亡。术后并发症戴瓦氏手术：１例截瘫，２例椎体骨折伴螺丝钉拔出，２例螺丝钉折断，２例金属缆折断；斯伍基氏手术，１例杆折断，２例切口感染。     

郑州市尘肺流行病学调查研究

尘肺是我国工业生产中危害最严重的职业病。1988年以来,郑州市持续开展了尘肺流行病学调查。1992年全市粉尘作业厂矿接尘人数为103542人,尘肺累积病人2758例,其中现患2541例,死亡217例。尘肺累积患病比为2.59%,现患率为2.39%,病死率为7.87%。尘肺累积病例以巩义市、郑州矿务局、密县为较多;按系统以煤炭(包括县煤炭)、机械、轻工、有色金属为多;尘肺病主要为矽肺及煤工尘肺。统计分析各种尘肺的发病工龄、发病年龄、死亡年龄以及各期别晋级年限等数据。对郑州市尘肺的发展趋势作了预测。     

9-顺式维甲酸体外诱导神经母细胞瘤细胞分化的研究

目的：为设计维甲酸治疗神经母细胞瘤可能的有效方案，本文对9-顺式维甲酸（9-cis retinoic acid,9-cisRA)体外诱导分化神经母细胞瘤细胞（SK-N-SH）作用进行了研究。方法：SK-N-SH细胞经9-cisRA处理后，采用相差显微镜，神经纤维银染法，透射电镜观察等手段。观察9-cisRA对细胞生长的影响。结果：9-cisRA作用SK-N-SH细胞7d后，细胞形态发生变化；12d时出现神经原性表型，多个细胞形成“神经节”，节间形成粗而长的类神经纤维；尼氏小体和银染法亦证明细胞产生显著分化，透射电镜观察结果表明，9-cisRA对该细胞有分化作用。却无明显凋亡诱导作用。结论：9-cisRA对神经母细胞瘤细胞体外能产生明显诱导分化作用。