山羊急性心肌缺血时恶性心律不齐的发生和...

The coronary collateral circulation of goat is very spare, so myocardiac ischemia model of goat can simulate the patient previously with normal coronary circulation and suddenly developing complete occlusion of coronary arteries. In this study 80 Chengdu goats were used, and the branches of their left coronary artery were ligated. Ventricular tachycardia (VT) developed in 23 goats and ventricular fibrillation (VF) in 39 goats. VT and VF both occurred in the early phase of acute myocardial ischemia, and both had 6 min as the median time of onset. In 71 cases data on the weight of myocardiac ischemic area were collected, in which the weight percentage of ischemic area relating to the ventricles of 34 goats with VF was significantly higher than that of 37 goats without VF (35.4 +/- 2.4% vs 19.5 +/- 1.9%). After coronary ligation, 9 cases directly precipitated into VF which could not be defibrillated. In the remaining 62 cases, the weight percentage of ischemic area of 21 cases with VT was higher than that of 41 cases without VT (32.9 +/- 2.8% vs 20.9 +/- 2.1%). The relationships between the incidence of VT or VF and the weight percentage of ischemic area were fitted with logistic curve. The likelihood of occurrence of VT or VF is increased as the weight percentage of ischemia area goes up.     

牙源性脓肿标本中的产黑色素类杆菌群菌株分离鉴定

本文对４４例牙源性脓肿（尖周脓肿２４例，牙周脓肿１２例，冠周脓肿８例）脓液标本中的产黑色素类杆菌群菌株进行分离、培养、鉴定。其中３８例存在产黑菌群，以中间型类杆菌阳性率最高。牙龈类杆菌在牙周脓肿中检出率最高。２４例尖周脓肿可分离出６株牙髓类杆菌而其它两种牙源性脓肿则无牙髓类杆菌，推测该菌与牙髓尖周感染的病理过程有关。     

天麻素对缺血再灌注神经细胞膜的保护作用

用新生Wistar大鼠大脑皮层进行神经细胞培养 ,将培养 8d的神经细胞置于模拟“缺血”状态下 ,5h后神经细胞发生肿胀 ,胞内乳酸脱氢酶 (LDH)漏出增加 ,膜流动性下降、脂质过氧化(LPO)含量增加 ;将经过“缺血”损伤神经细胞置 1 8h模拟“再灌注” ,“再灌注”后细胞数目明显减少 ,LDH的漏出、膜流动性下降和LPO增加继续加重 ,说明细胞损伤进一步加重。经过天麻素孵育后的神经细胞“缺血”或“再灌注”后LDH的漏出及LPO含量明显低于损伤组 ,而膜流动性则明显高于损伤组。表明 :天麻素对体外培养神经细胞的缺血再灌注损伤有保护作用     

潘库溴铵在婴幼儿、儿童和成年人的药代动力学

研究观察年龄对潘库溴铵药代动力学的影响，选择24例施择期整形外科手术的患者，根据年龄分成三组：1组为5例婴幼儿，年龄0．75－2．95岁；2组为13例儿童，年龄4－14岁；3组为6例病人，年龄16－27岁，静注潘库溴铵100ug/kg后用改良蒌光法测定其血浓度，潘库溴铵的体内过程能用二室开放模型完整描述，年龄愈小，分布容积愈大，血浆清除率愈高，潘库溴铵的血药浓度愈低，V1（中央室分布容积），V2（周边室分布容积），Vdss(稳态分布容积），C1（血浆清除率）和AUC（曲线下面积）在三相间有明显差别，1组的T1／2β和MRT明显比2，3组长，但T1／2α和K21在三组间无明显差别。     

Advances in TCM Treatment of Senile Vascular Dementia

Senile vascular dementia refers to organic loss of intellectual function due to cerebral damages caused by insufficient blood supply. The following is a summaryon achievements in its etiology, pathogenic mechanism, type identification and treatment in TCM, and the compound formulas, special formulas and drugs, and thepatent drugs used successfully for its treatment.     

军队官兵演习后期的心理变化

为探讨军队官兵在演习后期的心理变化，本分析了军队官兵在演习后期存在放松心理，思乡情绪，自我肯定以及发泄心理等的原因，并提出了相关对策；为稳定演习官兵的思想情绪提供参考。     

前不均倾位51例临床分析

目的:探讨前不均倾位的诊断及处理方法,以期提高临床医师对前不均倾位的认识。方法:对我院1995年1月~2006年11月收治的51例前不均倾产妇的发病年龄、胎产次、发病原因、临床表现、母儿产时产后并发症及诊治方法进行分析。结果:50例前不均倾均以剖宫产结束分娩、母婴安全。1例自然分娩。结论:前不均倾位产时并发症多,不易做出早期诊断,对母婴危害大,难以经过阴道分娩,诊断一旦明确,应及时行剖宫产终止妊娠。     

皮质类固醇对哮喘患者T淋巴细胞亚群的影响

应用Ｔ淋巴细胞亚群单克隆抗体对类固醇治疗前后哮喘患者外周血Ｔ淋巴细胞亚群的变化进行检测，结果提示：类固醇治疗后ＯＫＴ８较治疗前增高，ＯＫＴ４／ＯＫＴ８比值较治疗前降低并且接近正常，说明Ｔ淋巴细胞是类固醇作用的靶细胞，类固醇可直接影响Ｔ细胞亚群分布，发挥其非特异性抗炎作用。     

人参皂甙对突触后膜β受体效应影响

人参皂甙(GS,10~(-4)g/ml)明显抑制大鼠门脉(RPV)自发活动张力,松弛豚鼠气管平滑肌(GPT)和减慢豚鼠右心房(GPRA)心率。 GS还增强异丙肾上腺素(Iso)对RPV自发活动张力抑制以及对GPT的松弛效应,但对抗Iso增加心率的效应。上述结果提示GS可能对突触后膜β受体效应起调谐剂(modulator)样作用。