Three-dimensional shape from non-homogeneous textures: carved and stretched surfaces

We examined the perception of 3D shape for surfaces folded, carved, or stretched out of textured materials. The textures were composed of sums of sinusoidal gratings or of circular dots, and were designed to differentiate between orientation and frequency information present in perspective images of the surfaces. Correct perception of concavities, convexities, saddles, and slants required the visibility of signature patterns of orientation modulations. These patterns were identical to those identified previously for developable surfaces (A. Li & Q. Zaidi, 2000; Q. Zaidi & L. Li, 2002), despite the fact that textures were statistically homogeneous on developable surfaces but not on carved or stretched surfaces. Frequency modulations in the image were interpreted as cues to distance from the observer, which led to weak but qualitatively correct percepts for some carved and stretched surfaces but to misperceptions for others, similar to the misperceptions for developable surfaces (A. Li & Q. Zaidi, 2003). Irrespective of whether texture on the surface is homogeneous or non-homogeneous, similar neural modules can be used to locate signature orientation modulations and thus extract shape from texture cues.     

Illuminant color perception of spectrally filtered spotlights

The color perceived to belong to the illumination of objects is often based on cues from the scene within which the objects are perceived, instead of being based on any view of the source itself. We present measurements of illuminant color estimation by human observers for moving, spectrally filtered spotlights. The results show that when only one illuminant is in the field of view, estimates of illuminant color are seriously biased by the chromaticities of the illuminated surfaces. When the surround of the spotlight is illuminated by a dimmer second light, spotlight matching moves toward veridical in most conditions. Simulations show that a gray-world model cannot be rejected as an adequate explanation for illuminant color estimation and provides as good a fit as a model that gives greater weights to the brightest surfaces. When the surrounding illuminant is brighter than the spotlight, the situation is similar to that of a moving filter. Spotlight matches are close to veridical, and the results can be fit by a model based on estimating both illuminants.     

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

We present an overview of Runx involvement in regulatory mechanisms that are requisite for fidelity of bone cell growth and differentiation, as well as for skeletal homeostasis and the structural and functional integrity of skeletal tissue. Runx-mediated control is addressed from the perspective of support for biological parameters of skeletal gene expression. We review recent findings that are consistent with an active role for Runx proteins as scaffolds for integration, organization and combinatorial assembly of nucleic acids and regulatory factors within the three-dimensional context of nuclear architecture.     

New oligodendrocytes are generated after neonatal hypoxic-ischemic brain injury in rodents

Neonatal hypoxic-ischemic (HI) white matter injury is a major contributor to chronic neurological dysfunction. Immature oligodendrocytes (OLGs) are highly vulnerable to HI injury. As little is known about in vivo OLG repair mechanisms in neonates, we studied whether new OLGs are generated after HI injury in P7 rats. Rats received daily BrdU injections at P12-14 or P21-22 and sacrificed at P14 to study the level of cell proliferation or at P35 to permit dividing OLG precursors to differentiate. In P14 HI-injured animals, the number of BrdU+ cells in the injured hemisphere is consistently greater than controls. At P35, sections were double-labeled for BrdU and markers for OLGs, astrocytes, and microglia. Double-labeled BrdU+/myelin basic protein+ and BrdU+/carbonic anhydrase+ OLGs are abundant in the injured striatum, corpus callosum, and the infarct core. Quantitative studies show four times as many OLGs are generated from P21-35 in HI corpora callosa than controls. Surprisingly, the infarct core contains many newly generated OLGs in addition to hypertrophied astrocytes and activated microglia. These glia and non-CNS cells may stimulate OLG progenitor proliferation or induce their migration. At P35, astrogliosis and microgliosis are dramatic ipsilaterally but only a few microglia and some astrocytes are BrdU+. This finding indicates microglial and astrocytic hyperplasia occurs shortly after HI but before the P21 BrdU injections. Although the neonatal brain undergoes massive cell death and atrophy the first week after injury, it retains the potential to generate new OLGs up to 4 weeks after injury within and surrounding the infarct.     

Successful treatment of systemic and central nervous system lymphomatoid granulomatosis with rituximab

Lymphomatoid granulomatosis (LYG) is a rare lymphoproliferative disorder with a mortality rate approaching 60% in the first year. The median survival is 14 months from the time of diagnosis. Although a variety of chemotherapeutic regimens have been utilized, there is no standard treatment. Studies have shown that in most cases the malignant cells are B-cells, which induce massive infiltration of reactive T-lymphocytes in the background. The disease is therefore considered as a T-cell rich B-cell lymphoproliferative disorder. We report a case of LYG with pulmonary, hepatic, central and peripheral nervous system involvement that was successfully treated with the anti-CD20 (B-cell) monoclonal antibody, Rituximab.     

Predicting the outcome of patients with unexplained syncope undergoing prolonged monitoring

Patients with unexplained syncope are often considered candidates for prolonged monitoring or empiric pacing when noninvasive and invasive investigations fail to provide a diagnosis. Identifying the outcome of patients undergoing prolonged monitoring that would ultimately benefit from empiric pacing may permit a cost-effective approach to resolution of syncope. Two hundred and six patients (age 57 +/- 18 years, 57% male) underwent prolonged monitoring with an implanted loop recorder for syncope of unknown origin. The median number of previous syncopal episodes was four (mean 29 +/- 133). Prior tilt testing was performed in 63% of patients, and electrophysiological testing in 46%. Symptoms recurred during follow-up in 142 patients (69%). Recurrence was associated with bradycardia leading to pacemaker implantation in 35 patients (17.0%), tachycardia in 12 (5.8%), sinus rhythm in 63 (30.6%), neurally mediated syncope based on rhythm and clinical assessment in 22 (11%), and failed activation in 10 (5%). Logistic regression analysis of baseline variables found that age was the only independent variable that predicted the need for pacing, associated with a 3% increase in risk per advancing year of age (odds ratio 1.027, P = 0.026). Despite this finding, no age group could be identified in which the likelihood of requiring pacing exceeded 30%. Logistic regression also found that patients with structural heart disease were less likely to experience recurrent symptoms during monitoring (49% vs 78%, P = 0.001) and that advancing age was associated with earlier recurrence of symptoms (P = 0.01). The etiology of recurrent syncope is diverse and cannot be predicted by baseline clinical variables. Empiric pacing appears to have little role in the management of this patient population.     

Mutation in the cartilage-derived morphogenetic protein-1 (CDMP1) gene in a kindred affected with fibular hypoplasia and complex brachydactyly (DuPan syndrome)

The present authors have previously described a consanguineous Pakistani family with fibular hypoplasia and complex brachydactyly (DuPan syndrome) inherited as an autosomal recessive trait. All affected individuals showed either reductions or absence of bones in the limbs, and appendicular bone dysmorphogenesis with unaffected axial bones. Obligate heterozygote parents were phenotypically normal. Mutations in the cartilage-derived morphogenetic protein 1 (CDMP1) gene have been reported in two acromesomelic chondrodysplasias (i.e. Hunter-Thompson type and Grebe type) which are phenotypically related to DuPan syndrome. CDMP1, a member of the transforming growth factor beta super-family of secreted signalling molecules, has been reported to regulate limb patterning and distal bone growth. Therefore, the present authors examined genomic DNA from the family with DuPan syndrome for mutations in the CDMP1 gene. Affected individuals were homozygous for a missense mutation, T1322C, in the coding region of the CDMP1 gene. This mutation was not found in 44 control subjects of Pakistani origin. The T1322C change predicts a leu441pro substitution in the mature domain of the CDMP1 protein. This is likely to cause a conformational change in the CDMP1 protein that influences the expression of genes which are required for normal bone development. This finding extends the spectrum of phenotypes produced by defects in the CDMP1 gene.     

Time-course of S-cone system adaptation to simple and complex fields

We examine the temporal nature of adaptation at different stages of the S-cone color system. All lights were restricted to the S-cone-only (a constant L and M) cardinal axis in color space passing through mid-white (W). The observer initially adapted to a steady uniform field with a chromaticity on the -S end of the axis or on the +S end of the axis or a complex field composed of chromaticy -S and +S (+/-S adaptation). The observer then readapted to a steady uniform field of chromaticity W for a variable length of time (i.e., 0, 0.1, 0.25, 0.5, 1.0, or 2.0 s). A probe-flash technique was used to measure S-cone discrimination at various points along the S-cone-only cardinal axis. This allowed estimation of the response of the S-cone system over an extended response range. Following exposure to the -S and +S uniform fields, sensitivity was maximal at or near the chromaticity of the initial adaptation field and decreased linearly away from the adapting point. The shift from +S to W occurred more rapidly than the shift from -S to W; both of these shifts can be described by a multiplicative scaling of the S-cone signal. Following +/-S adaptation the threshold curve initially had a shape similar to that measured following -S adaptation, but returned rapidly to the W adaptation state. The shift following +/-S adaptation cannot be described by the multiplicative model, but can be explained by a change in the shape of the non-linearity. The results suggest the existence of fast post-receptoral processes.     

Interactions between color and luminance in the perception of orientation

At the early stages of visual processing in humans and other primates, chromatic signals are carried to primary visual cortex (V1) via two chromatic channels and a third achromatic (luminance) channel. The sensitivities of the channels define the three cardinal axes of color space. A long-standing though controversial hypothesis is that the cortical pathways for color and form perception maintain this early segregation with the luminance channel dominating form perception and the chromatic channels driving color perception. Here we show that a simple interaction between orientation channels (the tilt illusion) is influenced by both chromatic and luminance mechanisms. We measured the effect of oriented surround gratings upon the perceived orientation of a test grating as a function of the axes of color space along which the gratings were modulated. We found that the effect of a surround stimulus on the perceived orientation of the test is largest when both are modulated along the same axis of color space, regardless of whether that is a cardinal axis. These results show that color and orientation are intimately coupled in visual processing. Further, they suggest that the cardinal chromatic axes have no special status at the level(s) of visual cortex at which the tilt illusion is mediated.