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111.
Yu Jin Zhengyi Feng Ju Zhao Jinxiao Hu Yuanyuan Tong Shengwen Guo Peiyao Zhang Liting Bai Yixuan Li Jinping Liu 《Artificial organs》2021,45(1):6-14
Mortality and morbidity of children received veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) support after cardiac surgery remain high despite remarkable advances in medical management and devices. The purpose of this study was to describe outcomes and risk factors of applying VA‐ECMO in the surgical pediatric population. We retrospectively analyzed 85 consecutive pediatric patients (aged <18 years) who received postcardiotomy VA‐ECMO from January 2010 to December 2018. Median (IQR) age at ECMO implantation in this cohort was 12.7 (6.4, 43.2) months, median weight was 8.5 (6.0, 12.8) kg, mean ECMO duration was 143.2 ± 81.6 hours and mean hospital length of stay was 48.4 ± 32.4 days. Seventy‐five patients (88.2%) were indicated for postcardiotomy cardiogenic shock. The successful ECMO weaning rate was 70.6% and in‐hospital mortality was 52.9%. The most common diagnosis was transposition of great arteries (n = 18, 21.2%), while acute kidney injury occurred most often (n = 64, 75.3%). Multivariate logistic regression analysis showed that thrombocytopenia, hemolysis, and nosocomial infection were positively correlated with in‐hospital mortality. Multivariate Cox proportional hazard regression analysis presented that thrombocytopenia significantly increased the 180‐day mortality in patients with successful weaning. Therefore, multiple factors had adverse effects on prognosis. Patient selection and procedures from ECMO implantation to weaning need to be closely monitored and performed in a timely manner to improve outcome. 相似文献
112.
Li Chunjing Guo Liwen Luo Mi Guo Mingjuan Li Jierong Zhang Shilin Liu Guoqing 《International urology and nephrology》2021,53(10):1987-1993
International Urology and Nephrology - Ureteroscopy is widely applied in pregnant women with renal colic, but such patients are easy to experience uterine contraction after surgery. There are many... 相似文献
113.
Qiu Zhi Guo Quan-bin Ablikim Zakir Shi Xu-wen Hou Jiang-jiang Chen Chang Hasanjan Mamat Akbarjan Mamat Anwar Abdukadir 《International urology and nephrology》2021,53(10):1969-1976
International Urology and Nephrology - This article analyzed the safety and efficacy of ultrasound-guided mini-percutaneous nephrolithotomy (MPCNL) with low-pressure perfusion for the treatment of... 相似文献
114.
Ya-hui Xu Yue Li Su-qin Hu Chun-rui Li Dian-long Liu Ke Hu Li-dan Cui Jian Guo 《Andrologia》2021,53(9):e14169
The blood–testis barrier (BTB) of Sertoli cells (SCs) is an important biological barrier that maintains spermatogenesis and provides a favourable microenvironment for spermatogenesis. However, heat stress can directly damage the BTB structural proteins of testicular SCs, leading to dyszoospermia. Wuzi Yanzong Pills (WYP) is a traditional Chinese medicine formula used to treat male reproductive diseases. However, whether WYP could ameliorate heat stress injury in primary SCs extracted from rat testes and BTB proteins remains unknown. Here, treatment with WYP (low, medium and high dose) increased the SC viability and the proliferation of cell antigen Ki67 significantly. Additionally, it promoted SC maturation, which presented in the form of increased androgen receptors (ARs) and decreased cytokeratin 18 (CK-18) in three WYP dose groups. WYP upregulated BTB proteins such as zonula occludens 1 (ZO-1) and occludin across all WYP groups and decreased phosphorylated Akt (p-Akt) in the middle and high-dose groups; however, ZO-1 and occludin recovery were reduced with the presence of Akt inhibitor in WYP groups. WYP improved SC viability and proliferation, and ameliorated dedifferentiation and BTB-proteins damaged by heat stress via Akt signalling. The findings present theoretical support for the effects of WYP in the management of dyszoospermia and male infertility. 相似文献
115.
Feng Zhang Yingmei Wang Yuying Wang Xinli Wang Dawei Zhang Xiong Zhao Runmin Jiang Yu Gu Guifang Yang Xin Fu Longyong Xu Longxia Xu Liting Zheng Jing Zhang Zengshan Li Qingguo Yan Jianguo Shi Albert Roessner Zhe Wang Qing Li Jing Ye Charlie Degui Chen Shuangping Guo Jie Min 《Journal of bone and mineral research》2021,36(10):1931-1941
116.
目的:观察八珍益母胶囊辅助治疗子宫腺肌病的临床疗效。方法:选择80例气滞血瘀型子宫腺肌病患者,按随机数字表法分为对照组与观察组各40例。对照组采用孕三烯酮、双氯芬酸钠治疗,观察组在对照组的基础上联合八珍益母胶囊辅助治疗。比较2组治疗前后子宫体积、痛经评分、中医证候积分、疼痛指标[血清前列腺素E2(PGE2)、5-羟色胺(5-HT)]水平及临床疗效。结果:观察组总有效率为90.00%,显著高于对照组72.50%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组小腹胀痛、块下痛减、经行不畅、烦躁易怒、胸闷不舒、乳房胀痛、经血色紫有块、经血量少等证候评分及总分比较,差异均无统计学意义(P>0.05);治疗后,2组上述各项证候评分及总分均较治疗前显著降低(P<0.05),且观察组各项评分及总分均低于对照组(P<0.05)。治疗前,2组子宫体积、痛经评分比较,差异无统计学意义(P>0.05);治疗后,2组子宫体积、痛经评分均较治疗前显著降低(P<0.05),且观察组上述2项指标均低于对照组(P<0.05... 相似文献
117.
118.
Xu Li Siming Li Zhihong Chi Chuanliang Cui Lu Si Xieqiao Yan Lili Mao Bin Lian Bixia Tang Xuan Wang Xue Bai Li Zhou Yan Kong Jie Dai Jun Guo Xinan Sheng 《Urologic oncology》2021,39(1):75.e1-75.e8
PurposeTo investigate the clinical characteristics, chemosensitivity, and outcome of metastatic upper tract urothelial carcinoma (UTUC).Patients and MethodsRecords of patients with metastatic UTUC since January 2005 were retrieved from a database that included clinical and survival data. Statistical analyses including survival and multivariate analyses of factors were respectively performed by the Kaplan-Meier method and Cox proportional hazard model.ResultsA total of 250 consecutive UTUC cases were evaluated. There were 56 patients (22.4%) with initially diagnosed stage IV disease. The most common metastatic sites were lung (39.6%), distant lymph nodes (39.2%), bone (19.6%), liver (18.0%), and adrenal gland (7.2%), respectively, and the local recurrence rate was 10.4%. Two hundred thirteen patients received first-line chemotherapy. The overall response rate was only 28.7% and the median progression-free survival time was only 5.0 months. The overall survival time of the cohort was 18.0 months. Multivariate analyses showed that initially diagnosed stage IV disease, number of metastatic organs ≥3, no response to chemotherapy and cycles of chemotherapy ≤2 were adverse prognosticators for overall survival.ConclusionUTUC presented to be more prone to metastasize than locally recur and thought to have low chemosensitivity. Stage IV disease at initial diagnosis, number of metastatic organs, response and cycles of chemotherapy were independent prognosticators for metastatic UTUC. 相似文献
119.
Zhenlang Guo Chiming Gu Siyi Li Shu Gan Yuan Li Songtao Xiang Leiliang Gong Shusheng Wang 《Urologic oncology》2021,39(3):171-179
Background: Patients with bladder cancer have a high risk of suicide. This study aimed to assess how bladder cancer increases suicide risk and to identify the demographic and clinical factors associated with suicidal death among patients with bladder cancer. Methods: Literature search of MEDLINE, PsycINFO, Embase, Web of Sciences and Cochrane Library databases was conducted up to April 2020 to identify eligible studies related to the incidence and risk factors of suicide after bladder cancer diagnosis. Summary multivariate-adjusted risk estimates and their associated 95% confidence intervals (CIs) were calculated using inverse variance method with random or fixed-effect modeling. Results: Five retrospective cohorts comprising 563,680 patients with bladder cancer were included. Higher risk of suicide by 1.90-fold was observed among patients with bladder cancer (hazard ratio, HR = 1.90, 95% CI: 1.29–2.81; P = 0.001; I2 = 81.2%), especially in those aged 70 years or older (HR = 1.36, 95% CI: 1.29–1.43; P < 0.001; I2 = 0%), unmarried (HR = 1.72, 95% CI: 1.61–1.83; P < 0.001; I2 = 0%), and those with regional bladder cancer (HR = 1.88, 95% CI: 1.10–3.21; P = 0.021; I2 = 96.3%), compared with those without bladder cancer. Furthermore, gender and race were not associated with increased suicide risk among patients with bladder cancer. Conclusions: Suicide risk is increased among patients with bladder cancer, particularly those aged 70 years or older, unmarried and those with regional bladder cancer. Hence, early psychological support must be provided during the follow-up period of these special populations with a high suicide risk. 相似文献
120.
Zhang Junjun Wang Yongli Liu Zhangsuo Huang Bo Wang Xutong Xie Minhua Yu Dan Guo Ruxue Wang Panfei 《Clinical and experimental nephrology》2021,25(8):865-874
Clinical and Experimental Nephrology - In this study, we investigated the clinical and pathologic characteristics and prognosis of overlapping obesity-related glomerulopathy (ORG) and... 相似文献