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51.
Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+ T‐cell cross‐priming 下载免费PDF全文
Cynthia M. Fehres Sven C. M. Bruijns Astrid J. van Beelen Hakan Kalay Martino Ambrosini Erik Hooijberg Wendy W. J. Unger Tanja D. de Gruijl Yvette van Kooyk 《European journal of immunology》2014,44(8):2415-2424
Toll‐like receptor (TLR) ligands are attractive candidate adjuvants for therapeutic cancer vaccines, since TLR signaling stimulates and tunes both humoral and cellular immune responses induced by dendritic cells (DCs). Given that human skin contains a dense network of DCs, which are easily accessible via (intra‐)dermal delivery of vaccines, skin is actively explored as an antitumor vaccination site. Here we used a human skin explant model to explore the potential of TLR ligands as adjuvants for DC activation in their complex microenvironment. We show that topical application of Aldara skin cream, 5% of which comprises the TLR7 agonist imiquimod, significantly enhanced DC migration as compared with that resulting from intradermal injection of the TLR7/8 ligand R848 or the soluble form of imiquimod. Moreover, Aldara‐treated DCs showed highest levels of the costimulatory molecules CD86, CD83, CD40, and CD70. Topical Aldara induced the highest production of pro‐inflammatory cytokines in skin biopsies. When combined with intradermal peptide vaccination, Aldara‐stimulated DCs showed enhanced cross‐presentation of the melanoma antigen MART‐1, which resulted in increased priming and activation of MART‐1‐specific CD8+ T cells. These results point to advantageous effects of combining the topical application of Aldara with antitumor peptide vaccination. 相似文献
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53.
Yvette Curtis Lisabeth Eddy Holly Feder Timothy Lower 《Sexual and Relationship Therapy》2013,28(4):322-334
Relationship satisfaction is influenced by sexual satisfaction, which in turn is dependent upon successful initiation of sexual activity. Heterosexual married couples (n = 15) kept written journals for two weeks, detailing sexual activity and use of sexual initiation cues (i.e., what they or their partners did to initiate sexual activity). The data from the journals were analyzed qualitatively to reveal common themes and trends in participants’ responses. Themes included physical touch, verbal requests for sexual activity and participants’ reactions to partners’ cues. Themes are defined and described, with examples provided. Gender differences in the use and recognition of cues are discussed. The findings are another step along the path to helping researchers, therapists and couples understand and better use sexual initiation cues, leading to greater sexual satisfaction. 相似文献
54.
Influence of ATP-Binding Cassette Polymorphisms on Neurological Outcome After Traumatic Brain Injury
J’mir L. Cousar Yvette P. Conley F. Anthony Willyerd Ajit A. Sarnaik Ava M. Puccio Philip E. Empey Patrick M. Kochanek Michael J. Bell David O. Okonkwo Robert S. B. Clark 《Neurocritical care》2013,19(2):192-198
Background
As important mediators of solute transport at the blood–brain and blood–cerebrospinal fluid barriers, ATP-binding cassette (ABC) transporters (including ABCB1, ABCC1, and ABCC2), impact the bioavailability of drugs and endogenous substrates in the brain. While several ABCB1, ABCC1, and ABCC2 single nucleotide polymorphisms (SNPs) have been identified, their impact on outcome after traumatic brain injury (TBI) is unknown.Hypothesis
ABCB1, ABCC1, and ABCC2 SNPs are associated with Glasgow Outcome Scale (GOS) score after TBI.Methods
DNA samples from 305 adult patients with severe TBI (Glasgow Coma Scale, GCS score ≤ 8) were genotyped for tagging SNPs of ABCB1 (rs1045642; rs1128503), ABCC1 (rs212093; rs35621; rs4148382), and ABCC2 (rs2273697). For each SNP, patients were dichotomized based on presence of variant allele for multivariate analysis to determine associations with GOS assigned at 6 months adjusting for GCS, Injury Severity score, age, and patient sex.Results
For ABCB1 rs1045642, patients homozygous for the T allele were less likely to be assigned poor outcome versus those possessing the C allele [CT/CC; odds of unfavorable GOS = 0.71(0.55–0.92)]. For ABCC1 rs4148382, patients homozygous for the G allele were less likely to be assigned poor outcome versus those possessing the A allele [AG/AA; odds of unfavorable GOS = 0.73(0.55–0.98)].Conclusions
In this single-center study, patients homozygous for the T allele of ABCB1 rs1045642 or the G allele of ABCC1 rs4148382 were found to have better outcome after severe TBI. Further study is necessary to replicate these very preliminary findings and to determine whether these associations are due to central nervous system bioavailability of ABC transporter drug substrates commonly used in the management of TBI, brain efflux of endogenous solutes, or both. 相似文献55.
56.
Meshkan Moghimi Erik Salentijn Yvette Debets-Ossenkop K H. Karagozoglu Tymour Forouzanfar 《Medicina oral, patología oral y cirugía bucal》2013,18(4):e627-e632
Objectives: Actinomycosis is a chronic suppurative granulomatous infection caused by the Actinomyces genus. Orocervicofacial actinomycosis is the most common form of the disease, seen in up to 55% of cases. All forms of actinomycosis are treated with high doses of intravenous penicillin G over two to six weeks, followed by oral penicillin V. Large studies on cervicofacial actinomycosis are lacking. Therefore proper guidelines for treatment and treatment duration are difficult to establish. The aim of this study is to establish effective treatment and treatment duration for orocervicofacial actinomycosis.
Study design: A Pubmed and Embase search was performed with the focus on treatment and treatment duration for cervicofacial actinomycosis. The hospital records of all patients presenting to our department with head and neck infection from January 2000 to December 2010 were reviewed, retrospectively. The following data were collected: age, gender, clinical presentation, aetiology, duration of symptoms, microbiological findings, treatment, and duration of treatment. The treatment and treatment duration is subsequently compared to the literature.
Results: The literature search provided 12 studies meeting the inclusion criteria. All studies were retrospective in nature. Penicillin or amoxicillin/clavulanic acid are the preferred antibiotic regimens found in the literature. Most of our patients were treated with a combination of penicillin G 12 million units/day and metronidazol 500 mg 3/day, most commonly for a duration of 1 – 4 weeks, being shorter than the 3 – 52 weeks reported in the literature.
Conclusion: When actinomycosis is suspected, our review has shown that a surgical approach in combination with intravenous penicillin and metronidazol until clinical improvement is seen, followed by oral antibiotics for 2 – 4 weeks is generally efficient.
Key words:Actinomycosis, actinomyces, actinomycosis treatment, cervicofacial infection, actinomycosis diagnosis, head and neck infection. 相似文献
57.
Francesca Waddington Catharina Hartman Yvette de Bruijn Martijn Lappenschaar Anoek Oerlemans Jan Buitelaar Barbara Franke Nanda Rommelse 《European neuropsychopharmacology》2018,28(9):994-1005
Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are frequently comorbid disorders. Emotion recognition problems are considered an important familial deficit in ASD, but this is unknown in ADHD. Very few studies have directly compared emotion recognition performance of youth with ASD and/or ADHD and of their unaffected siblings across age to quantify the contribution of emotion recognition problems to the ADHD phenotype. We therefore devised a study of 64 ASD+ADHD participants, 89 ASD-only participants, 111 ADHD-only participants, 122 unaffected ASD(+ADHD) siblings, 69 unaffected ADHD-only siblings and 220 controls aged 7–18 years, who had completed two tasks assessing auditory and visual emotion recognition. Factor analysis was used to detect underlying dimensions of emotion recognition capacity. Linear mixed models were used to compare performance across groups and to assess age effects. The factor-analysis revealed four factors separating speed and accuracy regarding visual and auditory emotion recognition. ASD+ADHD, ASD-only, and ADHD-only participants all performed worse than controls. ASD+ADHD, ASD-only, and ADHD-only participants did not differ in the severity of their emotion recognition problems. Both unaffected sibling groups performed intermediate between patients and controls. For ASD+ADHD and ADHD-only participants, group differences were more marked in adolescence than childhood, whereas in ASD participants this was not observed. We conclude that emotion recognition problems are a familial deficit in ADHD to a similar extent as in ASD. Emotion recognition problems specifically - and social cognition problems more generally - should be assessed in clinical practice for ADHD. 相似文献
58.
Informal caregivers’ views on the division of responsibilities between themselves and professionals: A scoping review 下载免费PDF全文
Yvette Wittenberg MSc Rick Kwekkeboom PhD Janneke Staaks MSc Arnoud Verhoeff PhD Alice de Boer PhD 《Health & social care in the community》2018,26(4):e460-e473
This scoping review focuses on the views of informal caregivers regarding the division of care responsibilities between citizens, governments and professionals and the question of to what extent professionals take these views into account during collaboration with them. In Europe, the normative discourse on informal care has changed. Retreating governments and decreasing residential care increase the need to enhance the collaboration between informal caregivers and professionals. Professionals are assumed to adequately address the needs and wishes of informal caregivers, but little is known about informal caregivers’ views on the division of care responsibilities. We performed a scoping review and searched for relevant studies published between 2000 and September 1, 2016 in seven databases. Thirteen papers were included, all published in Western countries. Most included papers described research with a qualitative research design. Based on the opinion of informal caregivers, we conclude that professionals do not seem to explicitly take into account the views of informal caregivers about the division of responsibilities during their collaboration with them. Roles of the informal caregivers and professionals are not always discussed and the division of responsibilities sometimes seems unclear. Acknowledging the role and expertise of informal caregivers seems to facilitate good collaboration, as well as attitudes such as professionals being open and honest, proactive and compassionate. Inflexible structures and services hinder good collaboration. Asking informal caregivers what their opinion is about the division of responsibilities could improve clarity about the care that is given by both informal caregivers and professionals and could improve their collaboration. Educational programs in social work, health and allied health professions should put more emphasis on this specific characteristic of collaboration. 相似文献
59.
Sonya S. Brady PhD Amanda Berry PhD CRNP Deepa R. Camenga MD MHS Colleen M. Fitzgerald MD MS Sheila Gahagan MD MPH Cecilia T. Hardacker MSN RN CNL Bernard L. Harlow PhD Jeni Hebert-Beirne PhD MPH D. Yvette LaCoursiere MD Jessica B. Lewis PhD MFT Lisa K. Low PhD CNM Jerry L. Lowder MD MSc Alayne D. Markland DO MSc Gerald McGwin PhD Diane K. Newman DNP ANP-BC FAAN Mary H. Palmer PhD David A. Shoham PhD Ariana L. Smith MD Ann Stapleton MD Beverly R. Williams PhD Siobhan Sutcliffe PhD Prevention of Lower Urinary Tract Symptoms 《Neurourology and urodynamics》2020,39(4):1185-1202
60.
Fiona Sewell Kathryn Chapman Paul Baldrick David Brewster Alan Broadmeadow Paul Brown Leigh Ann Burns-Naas Janet Clarke Alex Constan Jessica Couch Oliver Czupalla Andy Danks Joseph DeGeorge Lolke de Haan Klaudia Hettinger Marilyn Hill Matthias Festag Abby Jacobs David Jacobson-Kram Stephan Kopytek Helga Lorenz Sophia Gry Moesgaard Emma Moore Markku Pasanen Rick Perry Ian Ragan Sally Robinson Petra M. Schmitt Brian Short Beatriz Silva Lima Diane Smith Sue Sparrow Yvette van Bekkum David Jones 《Regulatory toxicology and pharmacology : RTP》2014