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991.
GliomaPredict: a clinically useful tool for assigning glioma patients to specific molecular subtypes
Aiguo Li Serdar Bozdag Yuri Kotliarov Howard A Fine 《BMC medical informatics and decision making》2010,10(1):38
Background
Advances in generating genome-wide gene expression data have accelerated the development of molecular-based tumor classification systems. Tools that allow the translation of such molecular classification schemas from research into clinical applications are still missing in the emerging era of personalized medicine. 相似文献992.
Michiko Ito Takashi Morita Shizuka Okazaki Mototaka Koto Yuri Ichikawa Ryoko Takayama Toshihiko Hoashi Hidehisa Saeki Naoko Kanda 《The Journal of dermatology》2019,46(6):515-521
Dietary habits can modulate the pathogenesis of atopic dermatitis. We evaluated these habits in adult Japanese patients with atopic dermatitis using a validated, brief‐type self‐administered diet history questionnaire and compared the results to those of age‐ and sex‐matched healthy controls. Patients with atopic dermatitis showed higher intakes of carbohydrate and potatoes and lower intakes of alcohol, niacin, meat and oils/fats compared with those of the healthy controls. The results of logistic regression analysis showed that the intake of alcohol was negatively associated with atopic dermatitis (odds ratio, 0.905; 95% confidence interval, 0.832–0.983; P = 0.0181). The intakes of vitamin B6 and fruit were positively correlated with the severity scoring of atopic dermatitis. Multiple regression analysis revealed that vitamin B6 intake was a predictor of the severity scoring of atopic dermatitis (β = 26.98508709, t = 2.3995292, P = 0.01933781). The intakes of vegetable fat, n‐6 polyunsaturated fatty acid, and confections were lower in the severe atopic dermatitis group (severity scoring of atopic dermatitis, ≥33) than those in the mild group. Atopic dermatitis is negatively associated with alcohol intake, and intake of vitamin B6 is a predictor of severity scoring of atopic dermatitis. The intake of n‐6 polyunsaturated fatty acid is lower in the severe atopic dermatitis group than that in the mild group. Further study is warranted on the relationships of these results with abnormal immune responses, impaired skin barrier or pruritus in atopic dermatitis. 相似文献
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995.
Jang Yuri Park Nan Sook Chiriboga David A. Yoon Hyunwoo An Sok Kim Miyong T. 《Journal of cross-cultural gerontology》2015,30(2):131-141
Journal of Cross-Cultural Gerontology - This study examined how social capital in ethnic communities (e.g., social cohesion, community support, community participation, and negative interaction)... 相似文献
996.
Xianyin Lai Mangilal Agarwal Yuri M. Lvov Chetan Pachpande Kody Varahramyan Frank A. Witzmann 《Journal of applied toxicology : JAT》2013,33(11):1316-1329
Halloysite is aluminosilicate clay with a hollow tubular structure with nanoscale internal and external diameters. Assessment of halloysite biocompatibility has gained importance in view of its potential application in oral drug delivery. To investigate the effect of halloysite nanotubes on an in vitro model of the large intestine, Caco‐2/HT29‐MTX cells in monolayer co‐culture were exposed to nanotubes for toxicity tests and proteomic analysis. Results indicate that halloysite exhibits a high degree of biocompatibility characterized by an absence of cytotoxicity, in spite of elevated pro‐inflammatory cytokine release. Exposure‐specific changes in expression were observed among 4081 proteins analyzed. Bioinformatic analysis of differentially expressed protein profiles suggest that halloysite stimulates processes related to cell growth and proliferation, subtle responses to cell infection, irritation and injury, enhanced antioxidant capability, and an overall adaptive response to exposure. These potentially relevant functional effects warrant further investigation in in vivo models and suggest that chronic or bolus occupational exposure to halloysite nanotubes may have unintended outcomes. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
997.
Olga V. Kupriyanova Vadim A. Shevyrin Yuri M. Shafran 《Drug testing and analysis》2022,14(6):1102-1115
N-(2-substituted benzyl)-2,5-dimethoxyphenethylamines often cause severe poisonings which has led to their legal prohibition in many countries. At the same time, their positional isomers can be studied as potential therapeutic drugs. In this regard, the search for various approaches to differentiate these isomers is an important practical task, the solution of which would guarantee from identification errors during laboratory analysis. In this paper, the possibilities of differentiation of isomers varying in the position of two methoxy groups in the phenylethyl part of the molecule are considered on the example of compounds of NBF, NBCl, and NBBr series by chromatography-mass spectrometry methods. Gas or liquid reverse-phase chromatography in the proposed chromatographic separation modes has demonstrated their ability to resolve this problem reliably. Data on retention indices of isomeric compounds and their derivatives can serve as an additional identification criterion for gas chromatography–mass spectrometry (GC-MS) analysis. Differentiation of NBF and NBCl isomers using electron ionization (EI) mass spectra is feasible only if both the spectrum of the compound and its N-trifluoroacetyl derivative are registered; differentiation of NBBr positional isomers under these conditions does not require obtaining the derivatives. Using electrospray ion source, the compounds can easily be differentiated based on the distinctive features of their collision induced dissociation (CID) spectra recorded at low energy values, which also does not require the synthesis of derivatives. The data presented in current paper will be useful for analysis in laboratories providing the determination of narcotic drugs. 相似文献
998.
Cutaneous apocrine carcinoma of the scrotum: A case with widespread subcutaneous induration
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Takuya Miyagawa Takafumi Kadono Takashi Taniguchi Kouki Nakamura Ryosuke Saigusa Ayumi Yoshizaki Tomomitsu Miyagaki Daisuke Yamada Yuri Masui Shinichi Sato 《The Journal of dermatology》2015,42(8):815-817
Cutaneous apocrine carcinoma (CAC) is a rare malignancy. It develops predominantly in the regions where apocrine glands are distributed. Some cases of CAC have been reported in the axilla and the inguinal regions, but only a few in the scrotum. We herein report a case of CAC which widely spread over both sides of the whole scrotum with plate‐like hard induration, and such a manifestation has never been reported before. CAC is known to have high rates of local recurrence or metastasis, and the efficacy of radiotherapy or chemotherapy has not been established. As therapeutic options for CAC are limited, it is critical to reach the diagnosis and treat at an early stage. 相似文献
999.
Takashi Suzuki Yutaka Kitagawa Yosuke Maruyama Satoshi Yamaguchi Yuri Sakane Hitoshi Miyamoto Yuichi Ohashi 《Journal of clinical microbiology》2013,51(12):4246-4248
We report two cases of conjunctivitis caused by Neisseria gonorrhoeae with reduced cephalosporin susceptibility. Patients showed no response to cefmenoxime eye drops and intravenous ceftriaxone administration. The patients'' condition improved after the addition of oral minocycline. The isolates contained the mosaic penA for reduction of β-lactam susceptibility. 相似文献
1000.
Yuri Knyazikhin Philip Lewis Mathias I. Disney Matti M?ttus Miina Rautiainen Pauline Stenberg Robert K. Kaufmann Alexander Marshak Mitchell A. Schull Pedro Latorre Carmona Vern Vanderbilt Anthony B. Davis Frédéric Baret Stéphane Jacquemoud Alexei Lyapustin Yan Yang Ranga B. Myneni 《Proceedings of the National Academy of Sciences of the United States of America》2013,110(27):E2438