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71.
Alex Y. Chang Z. Nora Tu Julia L. Smith Philip Bonomi Thomas J. Smith Peter H. Wiernik Ronald Blum 《Investigational new drugs》1995,13(2):137-141
Summary Fifty-five patients with metastatic non-small cell lung cancer (NSCLC) were entered into this phase II randomized study for evaluating three new agents: gallium nitrate, amonafide and teniposide. The patients had to have ECOG performance status 0 or 1, no prior chemotherapy, and adequate hematological, hepatic and renal functions. Forty-seven patients were eligible and evaluable. Fourteen were randomized to receive gallium nitrate, 18 to amonafide and 15 to teniposide. Seventy-four percent of eligible patients were male. The majority of patients (89%) had an ECOG performance status 1. ECOG grade 4 toxicity occurred twice in patients on gallium nitrate, seven times on amonafide and 18 times on teniposide. The cause of death was attributed to amonafide in one patient (from sepsis) and to teniposide in two patients (due to infection and leukopenia). There was no objective response in all the patients entered. The overall survival times ranged from 2 weeks to 156 weeks with a median of 23 weeks. There were no survival differences among the three treatment arms. We conclude that gallium nitrate, amonafide and teniposide are inactive in metastatic NSCLC and do not warrant any further testing in this disease.The contents of this study is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute. 相似文献
72.
我国较贫困地区农村学龄前儿童膳食状况 总被引:5,自引:0,他引:5
对1985~1989年7省较贫困的18个乡农村儿童膳食调查资料采用平均摄入量、临界值及概率法进行了总结分析。结果表明,6~24月龄母乳喂养儿的辅食品种单一,数量不足。断奶儿童各年龄组热能、蛋白质摄入量的平均值分别达RDA的92%~104%和76%~84%,但以RDA为界值,仍有53%~62%及74%~85%的儿童热能、蛋白质摄入量低,用概率法分析蛋白质、钙、维生素A、B2、C及铁摄入不足的人数比例分别是50%~60%、93%~97%、51%~87%、74%~86%、58%~66%和12%~47%。热能、蛋白质摄入量低于RDA值儿童的身高、体重明显低于摄入量高于RDA值的儿童。 相似文献
73.
Using the polymerase chain reaction (PCR)-based single strand conformation polymorphism (SSCP) analysis, we have examined the highly conserved regions of the p53 gene in 58 biopsy samples of head and neck tumors. Mutations were found in 13/58 (23%) tumor specimens, but not in 6 normal tissues. Ten of 13 mutations were due to single base changes and the remaining 3 were 1- or 8-base deletion mutants. These mutations were clustered in exons 5 and 7 and resulted in amino acid changes. Our results seem to indicate that mutations in the p53 gene contribute to a significant number of cases of the head and neck tumors including 20% of nasopharyngeal carcinoma biopsies. The relationship of Epstein-Barr virus or human papillomavirus and p53 gene mutations in this group of cancers was also analyzed and discussed. 相似文献
74.
75.
Ca-mediated stimulation of Cl secretion by reactive oxygen metabolites in human colonic T84 cells. 下载免费PDF全文
H Tamai T S Gaginella J F Kachur M W Musch E B Chang 《The Journal of clinical investigation》1992,89(1):301-307
Monochloramine (NH2Cl), a granulocyte-derived reactive oxygen metabolite (ROM), increases short-circuit current (Isc) in cultured T84 monolayers in a concentration-dependent manner up to nonlethal concentrations of 75 microM. Isc increases slowly after NH2Cl, reaching a peak value of 18 +/- 2 microA/cm2 20 min after addition. The Isc changes are persistent (lasting over 20-30 min), depend on medium Cl, and are inhibitable with bumetanide. 36Cl flux studies demonstrated that NH2Cl increases serosa-to-mucosa flux of Cl without changing mucosa-to-serosa flux, consistent with stimulation of electrogenic Cl secretion. Isc responses to NH2Cl, but not PGE2, are dependent on medium calcium. As demonstrated in fura-2-loaded T84 cells, NH2Cl increases free cytosolic calcium by influx of extracellular Ca2+ and by release of Ca2+ from endogenous stores. However, NH2Cl had no effect on phosphatidylinositol metabolism or cyclic nucleotide levels. We conclude that ROM directly stimulate electrolyte secretion, an effect in part mediated by increases in cytosolic Ca2+, possibly through increasing Ca2+ permeability of cellular membranes. 相似文献
76.
挫伤性屈光不正的眼超声生物学检测 总被引:4,自引:0,他引:4
对112例挫伤性屈光不正患者进行了超声生物学检测。结果提示,挫伤性近视患者眼球解剖结构存在两大变,即晶体前移和厚度增加,超声前房深度、晶本厚度在伤后的检测结果与对照组相比具显著性差异。并对挫伤屈光不正的发生机制进行了探讨。 相似文献
77.
采用石蜡切片免疫组化法,测定了48例胃癌组织中雌激素受体的分布。结果阳性者17例,阳性率35.4%;同时测定12例非肿瘤性胃粘膜(慢性炎症及胃溃疡)作为对照,结果仅1例阳性(8.3%),两者之间有明显差异(P<0.01)。各年龄组及性别间差异均无统计学意义。将胃癌分成分化型及未分化型(包括印戒细胞癌)两组,结果显示未分化型癌的阳性率(61.5%)比分化型者(18.2%)明显增高(P<0.0l)。表示雌激素在癌的发生、发展中有明显的刺激作用,癌细胞的生长及恶性度对雌激素有一定依赖性。临床上应用内分泌疗法对雌激素受体阳性肿瘤进行辅助治疗是行之有效的。 相似文献
78.
79.
A W Chiu M T Chen W J Huang S T Young C Cheng S W Huang C L Chu L S Chang 《European urology》1992,22(3):250-254
Laparoscopic nephrectomy was performed in 15 male pigs, the procedure was successful in 14. Extraction of the intact kidney through a 5-cm lower abdomen incision was done in 7 animals; complete destruction and evacuation of the kidney was accomplished by a round-knife suction device through a 1-cm port in another 7 pigs. Grossly, the specimen consisted of sausage-like tubular renal tissue and a small amount of tissue debris. Pathology revealed that the glomerular and tubular structures were well preserved, no interstitial hematoma could be found. Four ports were usually used, one 1-cm umbilical camera port, one 0.5-cm port for ureter traction, and two 1-cm working ports along the midclavicular line. All the pigs recovered uneventfully. The average operation time was 3 h 20 min. The application of endo-GIA (United States Surgical Corporation) for renal hilum reduced the operative time to 2 h 20 min. Complications included renal vein tear during endoclip application and cutting in the first case, mild subcutaneous emphysema in 2 cases. This first pig received exploratory laparotomy for the repair and ligation of the renal vein. No more major complications occurred with increasing experience. From this porcine experiment, we conclude that the combination of laparoscopy, a tissue destroyer and an endobag for the entrapment of kidney seem to be a promising technique for clinical nephrectomy. 相似文献
80.
目的研究采用自体静脉管套入吻合口并注入脑细胞生长肽的方法,对面神经损伤后功能恢复的影响.方法吻合神经断端后用自体静脉管套入吻合口并注入脑细胞生长肽.分析肌电图和观察表情肌功能恢复,比较两种方法对损伤的面神经功能恢复的影响.结果自体静脉管套入吻合口并注入脑细胞生长肽的方法,比传统方法表情肌功能恢复时间明显缩短,且一期修复比二期修复功能恢复时间明显缩短,差异具有非常显著性意义(P<0.01).两种方法修复面神经损伤,表情肌功能恢复后检测面神经传导速度差异无显著性意义(P>0.05).结论自体静脉管套入吻合口并注入脑细胞生长肽的方法是一种比较有前途的面神经修复方法. 相似文献