全文获取类型
收费全文 | 2954篇 |
免费 | 207篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 150篇 |
妇产科学 | 102篇 |
基础医学 | 292篇 |
口腔科学 | 62篇 |
临床医学 | 258篇 |
内科学 | 638篇 |
皮肤病学 | 123篇 |
神经病学 | 178篇 |
特种医学 | 198篇 |
外国民族医学 | 1篇 |
外科学 | 463篇 |
综合类 | 51篇 |
一般理论 | 2篇 |
预防医学 | 207篇 |
眼科学 | 33篇 |
药学 | 221篇 |
中国医学 | 24篇 |
肿瘤学 | 134篇 |
出版年
2023年 | 21篇 |
2022年 | 84篇 |
2021年 | 107篇 |
2020年 | 59篇 |
2019年 | 71篇 |
2018年 | 121篇 |
2017年 | 74篇 |
2016年 | 85篇 |
2015年 | 86篇 |
2014年 | 111篇 |
2013年 | 145篇 |
2012年 | 198篇 |
2011年 | 197篇 |
2010年 | 130篇 |
2009年 | 101篇 |
2008年 | 148篇 |
2007年 | 113篇 |
2006年 | 142篇 |
2005年 | 108篇 |
2004年 | 109篇 |
2003年 | 83篇 |
2002年 | 93篇 |
2001年 | 75篇 |
2000年 | 42篇 |
1999年 | 47篇 |
1998年 | 39篇 |
1997年 | 43篇 |
1996年 | 45篇 |
1995年 | 36篇 |
1994年 | 31篇 |
1993年 | 52篇 |
1992年 | 29篇 |
1991年 | 20篇 |
1990年 | 25篇 |
1989年 | 37篇 |
1988年 | 30篇 |
1987年 | 27篇 |
1986年 | 30篇 |
1985年 | 20篇 |
1984年 | 9篇 |
1983年 | 10篇 |
1982年 | 9篇 |
1981年 | 17篇 |
1980年 | 10篇 |
1979年 | 12篇 |
1978年 | 10篇 |
1977年 | 11篇 |
1976年 | 15篇 |
1975年 | 11篇 |
1971年 | 6篇 |
排序方式: 共有3170条查询结果,搜索用时 31 毫秒
71.
Mohammad Abd Alkhalik Basha Hossam M. Abdelrahman Maha Ibrahime Metwally Nader Ali Alayouty Nesreen Mohey Mohamed M.A. Zaitoun Hosam Nabil Almassry Hala Y. Yousef Ahmed A. El Sammak Sameh Abdelaziz Aly Hesham Youssef Algazzar Mohamed Abd El‐Aziz Mohamed Farag Walid Mosallam Waleed S. Abo Shanab Safaa A. Ibrahim Ekramy A. Mohamed Abd El Motaleb Mohamed Amira Hamed Mohamed Afifi Ola A. Harb Taghreed M. Azmy 《Journal of magnetic resonance imaging : JMRI》2021,53(1):292-304
72.
The objectives were to determine the prevalence and clinical significance of anti-cyclic citrullinated peptide (anti-CCP) antibodies in patients with juvenile idiopathic arthritis (JIA). Anti-CCP antibodies were checked by ELISA in 68 children with JIA, 38 males and 30 females with mean age of 10.6 (±4.02) years and disease duration of 3.7 (±1.8) years. Thirty-eight (56%) patients had polyarticular disease, 20 (29%) patients had oligoarticular disease and 10 (15%) patients had systemic onset disease. All patients had their antinuclear antibodies (ANA), rheumatoid factor (RF) and ESR checked and x-rays performed to look for erosions. Results were compared to those of 20 healthy children, 14 children with juvenile systemic lupus erythematosus (JSLE) and 30 adults with rheumatoid arthritis (RA). Anti-CCP antibodies were positive in 14/68 (20.6%) patients with JIA, all had polyarticular-onset disease. All patients with positive anti-CCP antibodies had RF-positive polyarthritis. Anti-CCP antibodies were negative in all patients with oligoarticular-onset and systemic-onset disease including 2 patients with extended oligoarthritis. Anti-CCP antibodies were negative in healthy and JSLE controls but were positive in 20/30 (66.5%) adults with RA. Anti-CCP antibodies correlated significantly with joint erosions in patients with JIA (p?=?0.004) but no significant relation was found between anti-CCP antibodies and ANA positivity or raised ESR. These data confirm that anti-CCP antibodies are less prevalent in JIA than adult RA but are detectable in a significant proportion of RF-positive patients with polyarticular-onset JIA. The current study showed significant relation between anti-CCP positivity and erosive joint disease in JIA. 相似文献
73.
Muhammad Umer Siddiqui Ahmed K. Pasha Ibtisam Rauf Justin Z. Lee Muhammad Danial Siddiqui Youssef Yaacoub Mohammad Reza Movahed 《Clinical Medicine & Research》2021,19(1):19
Objective: The study objective was to determine if peri-operative bridging anticoagulation in patients with atrial fibrillation is beneficial or harmful.Design: Systematic review and meta-analysis.Setting: Inpatient or in-hospital setting.Participants: Adults with atrial fibrillation having a CHADS2 score >1 undergoing elective surgical procedure on anticoagulation.Methods: A systemic search of multiple databases (Cochrane, Medline, PubMed) was performed regarding studies conducted on efficacy and safety of perioperative bridging anticoagulation in patients with atrial fibrillation. Studies identified were reviewed by two authors individually before inclusion. The results were then pooled using Review Manager to determine the combined effect. Stroke/systemic embolism was considered as the primary efficacy outcome. Major bleeding was the primary safety outcome.Results: The systematic search revealed 108 potential articles. The full texts of 28 articles were retrieved for assessment of eligibility. After full text review, 25 articles were excluded. Three articles met inclusion criteria. No significant difference in stroke/systemic embolism with bridging anticoagulation was noted (risk ratio, 1.25-95% confidence interval [CI], 0.55–2.85). Bridging was associated with significantly higher risk of major bleeding (risk ratio, 3.29-95% CI, 2.25–4.81).Conclusion: An individualized approach is required when initiating peri-operative bridging anticoagulation. There is certainly a higher risk of bleeding with bridging anticoagulation and no difference in stroke/systemic embolism. However, the results cannot be extrapolated to patients who have valvular atrial fibrillation or CHADS2 score of 5 or greater. 相似文献
74.
75.
Tom C. Nguyen Matthew D. Terwelp Elizabeth H. Stephens David D. Odell Gabriel Loor Damien J. LaPar Walter F. DeNino Benjamin Wei Muhammad Aftab Ryan A. Macke Jennifer S. Nelson Kathleen S. Berfield John F. Lazar William Stein Samuel J. Youssef Vakhtang Tchantchaleishvili 《The Annals of thoracic surgery》2015,99(6):2070-2076
76.
Parathyroid hormone 1–34 enhances extracellular matrix deposition and organization during flexor tendon repair 下载免费PDF全文
Daniel J. Lee Richard D. Southgate Youssef M. Farhat Alayna E. Loiselle Warren C. Hammert Hani A. Awad Regis J. O'Keefe 《Journal of orthopaedic research》2015,33(1):17-24
Parathyroid hormone (PTH) 1–34 is known to enhance fracture healing. Tendon repair is analogous to bone healing in its dependence on the proliferation and differentiation of mesenchymal stem cells, matrix formation, and tissue remodeling.1,2,3 We hypothesized that PTH 1–34 enhances tendon healing in a flexor digitorum longus (FDL) tendon repair model. C57Bl/6J mice were treated with either intraperitoneal PTH 1–34 or vehicle‐control (PBS). Tendons were harvested at 3–28 days for histology, gene expression, and biomechanical testing. The metatarsophalangeal joint range of motion was reduced 1.5–2‐fold in PTH 1–34 mice compared to control mice. The gliding coefficient, a measure of adhesion formation, was 2–3.5‐fold higher in PTH 1–34 mice. At 14 days post‐repair, the tensile strength was twofold higher in PTH 1–34 specimens, but at 28 days there were no differences. PTH 1–34 mice had increased fibrous tissue deposition that correlated with elevated expression of collagens and fibronectin as seen on quantitative PCR. PTH 1–34 accelerated the deposition of reparative tissue but increased adhesion formation. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:17–24, 2015. 相似文献
77.
78.
Expression of chemokines and matrix metalloproteinases in early rheumatoid arthritis 总被引:2,自引:0,他引:2
Katrib A Tak PP Bertouch JV Cuello C McNeil HP Smeets TJ Kraan MC Youssef PP 《Rheumatology (Oxford, England)》2001,40(9):988-994
OBJECTIVE: To compare macrophage infiltration and expression of chemokines and matrix metalloproteinases (MMPs) in synovial tissue between patients with early and long-standing rheumatoid arthritis (RA). METHODS: Knee synovial biopsies were taken from 22 patients with early (<1 yr) and 22 patients with long-standing (>5 yr) RA and immunostained with antibodies specific for CD68; macrophage inflammatory protein (MIP)-1alpha and monocyte chemoattractant protein (MCP)-1; MMP-1 and -3 and the tissue inhibitors of metalloproteinases (TIMP)-l and -2. Immunostaining was quantified using a colour video image analysis system. RESULTS: CD68+ macrophage infiltration and the expression of MIP-1alpha, MCP-1, MMP-1, MMP-3, TIMP-1, and TIMP-2 were observed in synovial tissue of patients with early RA. In long-standing RA, there was a further increase in CD68+ macrophage infiltration and MIP-1alpha expression in the synovial lining layer. CD68 expression correlated with MIP-1alpha (R=0.39, P=0.01), but not with MCP-1 expression. CONCLUSION: Macrophage accumulation, and the expression of chemokines and MMPs in synovial tissue occur in early RA. Targeting chemokines which play a role in the migration of macrophages into the joints may be of therapeutic benefit in RA patients. 相似文献
79.
Platelet alpha-granule and plasma membrane share two new components: CD9 and PECAM-1 总被引:1,自引:2,他引:1
CD9 (p24) and PECAM1 (CD31) antigens are well-defined components of the platelet plasma membrane. Both are integral glycoproteins (GPs) implicated in the adhesive and aggregative properties of human platelets. In the present report, we have investigated their subcellular localization using immunoelectron microscopy. The monospecificity of the two polyclonal antibodies used was confirmed by immunoblotting. On normal resting platelets, immunolabeling for CD9 and PECAM1 was found lining the plasma membrane and the luminal face of the open canalicular system. Some labeling was also consistently found on the alpha-granule limiting membrane. This was confirmed by double labeling experiments in which fibrinogen and von Willebrand factor (vWF) were used as alpha-granule markers. CD9 and PECAM-1 were found lining the membrane of the same granules that contained fibrinogen and vWF in their matrix. CD9 and PECAM-1 thus appear to have an intracellular distribution identical to GPIIb-IIIa, a major aggregation platelet receptor. To rule out a cross-reactivity of the two polyclonal antibodies with GPIIb/IIIa, we studied PECAM1 and CD9 expression on the platelets from a patient with type I Glanzmann's thrombasthenia whose platelets are devoid of GPIIb/IIIa. The same pattern of labeling was observed for both antigens as for normal platelets. Normal platelets were further observed after stimulation by agonists that either fail to induce (ADP) or induce granule secretion (thrombin). After treatment with ADP, platelets changed shape and centralized their granules; the plasma membrane immunolabeling remained unchanged; and gold particles were still found decorating the periphery of the centralized alpha- granules. After thrombin treatment, alpha-granules fused with the platelet membrane and secretion occurred. A significant increase of labeling was then observed on the platelet surface. From these results we conclude that the alpha-granule membrane contains two additional receptors in common with the plasma membrane. This suggests that alpha- granule membrane receptors may originate from a dual mechanism: direct targeting from the Golgi complex in megakaryocytes (for alpha-granule- specific receptors such as P-selectin) or by endocytosis from the plasma membrane (for proteins distributed in the two compartments). 相似文献
80.
Y. El Miedany M. El Gaafary S. Youssef I. Ahmed Sami Bahlas M. Hegazi A. Nasr 《Clinical rheumatology》2016,35(12):2915-2923
This study aims to assess clinical, lab/immunological or imaging (joint ultrasonography) markers able to predict disease relapse in RA patients in sustained remission when tapering or stopping their treatment. One hundred fifty-seven RA patients in clinical remission (DAS-28 <2.6 for >6 months), receiving treatment with sDMARDs and bDMARD therapy, were randomly allocated into any of five groups: Group 1: continue full dose DMARDs and taper biologic therapy by 50 % (31 patients); Group 2: taper both DMARDs and biologic therapy dose by 50 % (32 patients); Group 3: taper DMARDs by 50 % and stop biologic therapy (31 patients); Group 4: stop both DMARDs and biologic therapy (31 patients); Group 5: continue medications without change (31 patients). Forty joints were assessed ultrasonographically (DAS-28 joints + ankles + metatarsophalangeal joints) and prospectively monitored for 12 months. The primary endpoint was sustained remission for 12 months. Patients were considered as having a relapse when the DAS-28 score was >3.2 and anti-rheumatic treatment was escalated. The frequency of relapse was 41.9 % in Group 1, 59.3 % in Group 2, 67.7 % in Group 3, 77.4 % in Group 4 and 6.5 % in Group 5. Relapse rates were significantly higher in patients whose ultrasound scores raised within 3 months of stopping their medications (P < 0.001 for both GS and PD scores). Cox regression identified ACPA positivity (at baseline) and progression of functional disability (at 2 months) as predictors for relapse. Tapering therapy is feasible in RA patients. Tailored dynamic approach is advised. Joint ultrasonographic assessment, ACPA positivity and worsening functional disability predicted relapse within a short term after discontinuation of the treatment. RA patients whose DAS-28 score was <2 were more likely to remain in remission. 相似文献