全文获取类型
收费全文 | 2278篇 |
免费 | 180篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 60篇 |
妇产科学 | 16篇 |
基础医学 | 263篇 |
口腔科学 | 56篇 |
临床医学 | 233篇 |
内科学 | 589篇 |
皮肤病学 | 34篇 |
神经病学 | 170篇 |
特种医学 | 93篇 |
外科学 | 296篇 |
综合类 | 34篇 |
一般理论 | 2篇 |
预防医学 | 111篇 |
眼科学 | 67篇 |
药学 | 109篇 |
中国医学 | 7篇 |
肿瘤学 | 305篇 |
出版年
2023年 | 13篇 |
2022年 | 10篇 |
2021年 | 43篇 |
2020年 | 27篇 |
2019年 | 47篇 |
2018年 | 54篇 |
2017年 | 52篇 |
2016年 | 47篇 |
2015年 | 74篇 |
2014年 | 110篇 |
2013年 | 116篇 |
2012年 | 167篇 |
2011年 | 157篇 |
2010年 | 108篇 |
2009年 | 87篇 |
2008年 | 121篇 |
2007年 | 141篇 |
2006年 | 141篇 |
2005年 | 127篇 |
2004年 | 112篇 |
2003年 | 107篇 |
2002年 | 103篇 |
2001年 | 76篇 |
2000年 | 67篇 |
1999年 | 60篇 |
1998年 | 23篇 |
1997年 | 19篇 |
1996年 | 18篇 |
1995年 | 21篇 |
1994年 | 11篇 |
1993年 | 12篇 |
1992年 | 31篇 |
1991年 | 12篇 |
1990年 | 16篇 |
1989年 | 7篇 |
1988年 | 8篇 |
1987年 | 16篇 |
1986年 | 10篇 |
1985年 | 11篇 |
1984年 | 12篇 |
1983年 | 6篇 |
1982年 | 9篇 |
1981年 | 6篇 |
1980年 | 5篇 |
1974年 | 3篇 |
1973年 | 5篇 |
1972年 | 3篇 |
1971年 | 8篇 |
1970年 | 5篇 |
1967年 | 5篇 |
排序方式: 共有2469条查询结果,搜索用时 15 毫秒
31.
32.
W Y Au A K Lie S K Ma L C Chan C K Lee Y L Kwong C S Chim T K Chan E Chiu R Liang 《Hematological oncology》1998,16(4):163-168
Between 1990 and 1997, we performed 29 allogeneic BMTs for acute lymphoblastic leukemia (ALL) patients with HLA-identical sibs. Their median age was 31 years (range 15 to 43); there were 15 males and 14 females. The conditioning protocol was Cy-TBI (n = 15), VP16-Cy-TBI(n = 12), CBV (n = 1) and Bu-Cy (n = 1). Cyclosporin and methotrexate were used for GVHD prophylaxis. The median disease-free survival (DFS) was 12 months (range 1 to 92) with an actuarial 4-years DFS of 42.3 per cent. Three patients died of transplant-related complications before 100 days. Relapse occurred in 11 cases at a median time of 5 months (range 3 to 14). All nine patients relapsing within one year died form resistant leukemia. Three patients died of late treatment-related complications. There were 13 survivors (median follow-up 38 months, range 12-98), with 12 in remission. Only four had limited cGVHD, and all had 100 per cent performance scores. One patient also cleared her chronic hepatitis B carrier status due to acquired immunity. The DFS rates amongst CR1 cases and R1/CR2 cases were comparable (p = 0.39). No long-term DFS is obtained from patients with resistant disease (n = 4). The survival results for BMT at CR1 were superior to those using intensive chemotherapy consolidation (p = 0.29), mainly due to poor late results in the chemotherapy arm. For young ALL patients with HLA-matched siblings, the option of BMT should be considered in light of local consolidation survival results. 相似文献
33.
34.
p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongue. 总被引:2,自引:0,他引:2
Rhonda A Kwong Larry H Kalish Tuan V Nguyen James G Kench Ronaldo J Bova Ian E Cole Elizabeth A Musgrove Robert L Sutherland 《Clinical cancer research》2005,11(11):4107-4116
PURPOSE: The INK4A-ARF locus at chromosome 9p21 is frequently altered in head and neck squamous cell carcinoma (SCC) and encodes two distinct tumor suppressors, p16(INK4A) and p14(ARF). This study addressed the role of p14(ARF) as a potential prognostic marker in this disease. EXPERIMENTAL DESIGN: p14(ARF) protein expression was assessed by immunohistochemistry in a cohort of 140 patients with SCC of the anterior tongue. Using univariate and multivariate Cox's proportional hazards models, the outcomes examined were time to disease recurrence or death, with or without clinicopathologic covariates, including nodal status, disease stage, treatment status, Ki-67 staining, and molecular markers with known functional or genetic relationships with p14(ARF) (p16(INK4A), p53, pRb, p21(WAF1/CIP1), E2F-1). RESULTS: On multivariate analysis, p14(ARF) positivity (nucleolar p14(ARF) staining and/or nuclear p14(ARF) staining in >/=30% of tumor cells) was an independent predictor of improved disease-free survival (DFS; P = 0.002) and overall survival (OS; P = 0.002). This was further enhanced when p14(ARF) positivity was cosegregated with positive (>/=1%) p16(INK4A) staining (DFS, P < 0.001; OS, P < 0.001). Patients whose cancers were p14(ARF) negative and p53 positive (>50%) had the poorest outcome (DFS, P < 0.001; OS, P < 0.001) of any patient subgroup analyzed. CONCLUSIONS: These data show that in patients with SCC of the tongue, combined nuclear and nucleolar expression of p14(ARF) protein predicts for improved DFS and OS independent of established prognostic markers. 相似文献
35.
36.
Francesca Curreli Young Do Kwon Hongtao Zhang Yongping Yang Daniel Scacalossi Peter D. Kwong Asim K. Debnath 《Antimicrobial agents and chemotherapy》2014,58(9):5478-5491
We previously identified two small-molecule CD4 mimetics—NBD-556 and NBD-557—and synthesized a series of NBD compounds that resulted in improved neutralization activity in a single-cycle HIV-1 infectivity assay. For the current investigation, we selected several of the most active compounds and assessed their antiviral activity on a panel of 53 reference HIV-1 Env pseudoviruses representing diverse clades of clinical isolates. The selected compounds inhibited tested clades with low-micromolar potencies. Mechanism studies indicated that they act as CD4 agonists, a potentially unfavorable therapeutic trait, in that they can bind to the gp120 envelope glycoprotein and initiate a similar physiological response as CD4. However, one of the compounds, NBD-09027, exhibited reduced agonist properties, in both functional and biophysical studies. To understand the binding mode of these inhibitors, we first generated HIV-1-resistant mutants, assessed their behavior with NBD compounds, and determined the X-ray structures of two inhibitors, NBD-09027 and NBD-10007, in complex with the HIV-1 gp120 core at ∼2-Å resolution. Both studies confirmed that the NBD compounds bind similarly to NBD-556 and NBD-557 by inserting their hydrophobic groups into the Phe43 cavity of gp120. The basic nitrogen of the piperidine ring is located in close proximity to D368 of gp120 but it does not form any H-bond or salt bridge, a likely explanation for their nonoptimal antagonist properties. The results reveal the structural and biological character of the NBD series of CD4 mimetics and identify ways to reduce their agonist properties and convert them to antagonists. 相似文献
37.
38.
39.
40.
Joseph Yun Kwong Kan Kitchai Rungcharassaeng Matteo Deflorian Tommaso Weinstein Hom‐Lay Wang Tiziano Testori 《Periodontology 2000》2018,77(1):197-212
An inevitable loss of soft and hard tissue after tooth extraction often results in a compromised site for anterior implant esthetics in both vertical and horizontal dimensions. Immediate implant placement and provisionalization has been a viable option for replacing failing maxillary anterior teeth as it preserves the vertical existing osseous and gingival architecture. With the simultaneous addition of soft‐ and hard‐tissue grafts, the peri‐implant horizontal tissue topography can also be maintained. The esthetic success of immediate implant placement and provisionalization procedures is influenced by a number of factors that can be identified as patient‐dependent or clinician‐dependent. This article describes in detail the process of patient selection, indications, contraindications, diagnosis, treatment planning and treatment execution required to achieve functional and esthetic success with immediate implant placement and provisionalization. 相似文献