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101.
Takashi Nonaka M.D. Kazunori Kajino Kojiro Michitaka Norio Horiike Morikazu Onji Yasuyuki Ohta 《Journal of gastroenterology》1990,25(2):276-276
This work was Supported by a Grant-in-Aid for Scientific Research(B) from the Ministry of Education, Science and Culture,
No 63480203. 相似文献
102.
Kentaro Yoshioka Yasuyuki Higashi Masaki Yamada Toshiyuki Aiyama Masahiro Takayanagi Kazuma Tanaka Akihiko Okumura Kazuo Iwata Shinichi Kakumu 《Liver international》1995,15(2):57-62
Factors predicting the efficacy of interferon therapy were statistically analyzed on 111 patients with chronic hepatitis C. Of the treated patients (total doses of interferon; 96–468 MU), 35 (31.5%) had a long-term remission. On multivariate analysis, hepatitis C virus genotype (p<0.0001), histological diagnosis (p<0.05), fibrosis score of histological activity index (p<0.01) and source of infection (p<0.05) were found useful for predicting the response to interferon therapy. Our findings suggest that the outcome of interferon therapy can be predicted to some degree from pretreatment data, and that a new therapeutic strategy is necessary for the group of patients who are predicted to be nonresponders. 相似文献
103.
Sadaoka K Okamoto S Gomi Y Tanimoto T Ishikawa T Yoshikawa T Asano Y Yamanishi K Mori Y 《The Journal of infectious diseases》2008,198(9):1327-1333
Cell-mediated immunity (CMI) is critical for the prevention and control of varicella-zoster virus (VZV)-related disease. To assess CMI to VZV, a varicella skin test and interferon-gamma enzyme-linked immunospot (ELISPOT) assay were both performed in healthy volunteers, and the results were compared. A total of 151 subjects were examined: 16 aged 20-29 years, 26 aged 30-39 years, 18 aged 40-49 years, 73 aged 50-59 years, and 18 aged 60-69 years. All were seropositive by a glycoprotein antigen-based enzyme-linked immunosorbent assay (gpELISA). Skin test reactivity was significantly correlated with the ELISPOT count, and both decreased with increasing age, indicating an age-dependent decline in CMI to VZV. In contrast, the antibody titer obtained by the gpELISA did not correlate with skin test reactivity. The results suggest that the skin test and ELISPOT assay are both reliable for assessing CMI to VZV and can easily be applied to screen individuals susceptible to the development of herpes zoster. 相似文献
104.
105.
Genomewide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis
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106.
107.
Akihiro Takahashi Masaya Umezaki Yasuyuki Yoshida Akinori Kuzuya 《Journal of biomaterials science. Polymer edition》2014,25(5):444-454
We report on the effects of number and length of PEG chains in poly(depsipeptide-co-dl-lactide)-g-poly(ethylene glycol) (P(DG-dl-LA)-g-PEG) copolymers on their sol-to-gel transition behavior. The graft-type copolymer is suitable for the systematic study of the effects of molecular structure and hydrophilic/hydrophobic balance on its sol-to-gel transition. We prepared various P(DG-dl-LA)-g-PEG copolymers through coupling reactions between the pendant carboxylic acid groups of P(GD-dl-LA) and the end hydroxyl group of MeO-PEG having various molecular weights. Temperature-responsive sol-to-gel transition of the obtained copolymer solution in phosphate-buffered solution (pH 7.4, ionic strength = 0.14) was investigated by the test tube inverting method and rheological measurements. P(GD-dl-LA)-g-PEG copolymer prepared from higher molecular weight PEG showed higher sol-to-gel transition temperatures compared with the copolymers prepared from lower molecular weight PEG, although these copolymers have similar weight content of PEG (23–24?wt.%). Similar trends were observed for groups of copolymers whose PEG contents were 27 or 30?wt.%. These results are informative for providing strategies on rational design of thermo-gelling polymers. 相似文献
108.
Tomoko Noma Mai Kabayama Yasuyuki Gondo Saori Yasumoto Yukie Masui Ken Sugimoto Hiroshi Akasaka Kayo Godai Atsuko Higuchi Yuya Akagi Yoichi Takami Yasushi Takeya Koichi Yamamoto Kazunori Ikebe Yasumichi Arai Tatsuro Ishizaki Hiromi Rakugi Kei Kamide 《Geriatrics & Gerontology International》2020,20(7):720-726
109.
110.