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101.
Kazuhiro Izawa Yasuyuki Hirano Sumio Yamada Koichiro Oka Kazuto Omiya Setsu Iijima 《Circulation journal》2004,68(4):315-320
BACKGROUND: The present study examined the impact of an 8-week cardiac rehabilitation (CR) program on physiological outcomes and health-related quality of life (HRQOL) of patients with acute myocardial infarction (AMI). METHODS AND RESULTS: A total of 124 consecutive AMI patients were divided into a supervised outpatient CR group (n=82) and a non-CR group as a control (n=42). Peak oxygen uptake, handgrip strength, and knee extension muscular strength were used as physiological outcome measures. HRQOL outcomes were assessed by the Medical Outcome Study Short Form 36 (SF-36). CR group patients performed both aerobic exercise and moderate resistance training from 1 month (T1) to 3 months (T2) after AMI onset. Age, sex, body mass index, medications, and ejection fraction were similar in both groups. Significantly greater increases in overall physiological outcomes from T1 to T2 were measured in the CR group compared with those of the non-CR group. There were also significantly greater improvements in 4 of the 8 SF-36 health status subscales (physical functioning, role-physical, general health, and vitality) in the CR group compared with the non-CR group. CONCLUSIONS: Eight weeks of exercise training have specific effects on improvement in HRQOL and physiological outcomes in Japanese patients. 相似文献
102.
Koichiro Higasa Jun-Ichi Manabe Toshitsuga Yubisui Hideki Sumimoto Parichat Pung-amritt Varavarn S. Tanphaichitr & Yasuyuki Fukumaki 《British journal of haematology》1998,103(4):922-930
Hereditary methaemoglobinaemia, caused by deficiency of NADH-cytochrome b5 reductase (b5R), has been classified into two types, an erythrocyte (type I) and a generalized (type II). We analysed the b5R gene of two Thai patients and found two novel mutations. The patient with type II was homozygous for a C-to-T substitution in codon 83 that changes Arg (CGA) to a stop codon (TGA), resulting in a truncated b5R without the catalytic portion. The patient with type I was homozygous for a C-to-T substitution in codon 178 causing replacement of Ala (GCG) with Val (GTG). To characterize effects of this missense mutation, we investigated enzymatic properties of mutant b5R (Ala 178 Val). Although the mutant enzyme showed normal catalytic activity, less stability and different spectra were observed. These results suggest that this substitution influenced enzyme stability due to the slight change of structure. In conclusion, the nonsense mutation led to type II because of malfunction of the truncated protein. On the other hand, the missense mutation caused type I, due to degradation of the unstable mutant enzyme with normal activities in patient's erythrocytes, because of the lack of compensation by new protein synthesis during the long life-span of erythrocytes. 相似文献
103.
Takashi Nonaka M.D. Kazunori Kajino Kojiro Michitaka Norio Horiike Morikazu Onji Yasuyuki Ohta 《Journal of gastroenterology》1990,25(2):276-276
This work was Supported by a Grant-in-Aid for Scientific Research(B) from the Ministry of Education, Science and Culture,
No 63480203. 相似文献
104.
Kentaro Yoshioka Yasuyuki Higashi Masaki Yamada Toshiyuki Aiyama Masahiro Takayanagi Kazuma Tanaka Akihiko Okumura Kazuo Iwata Shinichi Kakumu 《Liver international》1995,15(2):57-62
Factors predicting the efficacy of interferon therapy were statistically analyzed on 111 patients with chronic hepatitis C. Of the treated patients (total doses of interferon; 96–468 MU), 35 (31.5%) had a long-term remission. On multivariate analysis, hepatitis C virus genotype (p<0.0001), histological diagnosis (p<0.05), fibrosis score of histological activity index (p<0.01) and source of infection (p<0.05) were found useful for predicting the response to interferon therapy. Our findings suggest that the outcome of interferon therapy can be predicted to some degree from pretreatment data, and that a new therapeutic strategy is necessary for the group of patients who are predicted to be nonresponders. 相似文献
105.
Sadaoka K Okamoto S Gomi Y Tanimoto T Ishikawa T Yoshikawa T Asano Y Yamanishi K Mori Y 《The Journal of infectious diseases》2008,198(9):1327-1333
Cell-mediated immunity (CMI) is critical for the prevention and control of varicella-zoster virus (VZV)-related disease. To assess CMI to VZV, a varicella skin test and interferon-gamma enzyme-linked immunospot (ELISPOT) assay were both performed in healthy volunteers, and the results were compared. A total of 151 subjects were examined: 16 aged 20-29 years, 26 aged 30-39 years, 18 aged 40-49 years, 73 aged 50-59 years, and 18 aged 60-69 years. All were seropositive by a glycoprotein antigen-based enzyme-linked immunosorbent assay (gpELISA). Skin test reactivity was significantly correlated with the ELISPOT count, and both decreased with increasing age, indicating an age-dependent decline in CMI to VZV. In contrast, the antibody titer obtained by the gpELISA did not correlate with skin test reactivity. The results suggest that the skin test and ELISPOT assay are both reliable for assessing CMI to VZV and can easily be applied to screen individuals susceptible to the development of herpes zoster. 相似文献
106.
107.
Genomewide identification of target genes of histone methyltransferase dG9a during Drosophila embryogenesis
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108.
109.
Akihiro Takahashi Masaya Umezaki Yasuyuki Yoshida Akinori Kuzuya 《Journal of biomaterials science. Polymer edition》2014,25(5):444-454
We report on the effects of number and length of PEG chains in poly(depsipeptide-co-dl-lactide)-g-poly(ethylene glycol) (P(DG-dl-LA)-g-PEG) copolymers on their sol-to-gel transition behavior. The graft-type copolymer is suitable for the systematic study of the effects of molecular structure and hydrophilic/hydrophobic balance on its sol-to-gel transition. We prepared various P(DG-dl-LA)-g-PEG copolymers through coupling reactions between the pendant carboxylic acid groups of P(GD-dl-LA) and the end hydroxyl group of MeO-PEG having various molecular weights. Temperature-responsive sol-to-gel transition of the obtained copolymer solution in phosphate-buffered solution (pH 7.4, ionic strength = 0.14) was investigated by the test tube inverting method and rheological measurements. P(GD-dl-LA)-g-PEG copolymer prepared from higher molecular weight PEG showed higher sol-to-gel transition temperatures compared with the copolymers prepared from lower molecular weight PEG, although these copolymers have similar weight content of PEG (23–24?wt.%). Similar trends were observed for groups of copolymers whose PEG contents were 27 or 30?wt.%. These results are informative for providing strategies on rational design of thermo-gelling polymers. 相似文献
110.
Tomoko Noma Mai Kabayama Yasuyuki Gondo Saori Yasumoto Yukie Masui Ken Sugimoto Hiroshi Akasaka Kayo Godai Atsuko Higuchi Yuya Akagi Yoichi Takami Yasushi Takeya Koichi Yamamoto Kazunori Ikebe Yasumichi Arai Tatsuro Ishizaki Hiromi Rakugi Kei Kamide 《Geriatrics & Gerontology International》2020,20(7):720-726