原发性高血压患者脉压与窦性心律震荡相关性的研究

目的研究新的心电学指标——心律震荡(HRT)在原发性高血压患者中的变化,并探讨HRT和脉压的关系。方法选择我院2004年7月-2005年12月26例原发性高血压脉压增大患者和25例脉压正常的原发性高血压患者行24h动态心电图(Holter),计算HRT的两个参数震荡初始(TO)和震荡斜率(TS),并与脉压进行对比分析。结果原发性高血压脉压增大患者组与脉压正常患者组比较HRT异常明显,差异有显著性意义(P<0．05)。结论高血压患者脉压增大组HRT异常,提示原发性高血压脉压增大患者自主神经功能状态受损明显。     

药物制剂技术课程中PBL教学模式实践研究

目的为提高药物制剂技术课程的教学水平提供参考。方法选取学校2011级和2012级药学系学生作为对照班和试验班进行实践研究,采用以问题为导向的教学方法(PBL),在药物制剂技术课程中以药品生产真实案例为载体,坚持以养成学生自主学习、终身学习的能力为教育目标贯穿到整个教学过程,积极开展药物制剂技术的教学实践活动,以问卷调查结果和学生成绩进行对照。结果试验班学生喜欢药物制剂技术的人数明显多于对照班,探究能力明显强于对照班;试验班学生的药物制剂技术考试平均分比对照班高。结论在药物制剂技术的教学中运用PBL教学模式有利于提高教学效果,培养学生自主学习和终身学习的能力,为培养既有职业能力又有职业潜力的药学专业学生助力。但在实际实施过程中,因受师资条件和教学资料的限制,应将PBL教学与传统教学方法有机结合。     

Dosimetric analysis of tomotherapy-based intensity-modulated radiotherapy with and without bone marrow sparing for the treatment of cervical cancer

Objective The aim of the study was to compare tomotherapy-based bone marrow-sparing intensity-modulated radiotherapy(BMS-IMRT) with intensity-modulated radiotherapy(IMRT) without entering the pelvic bone marrow as a planning constraint in the treatment of cervical cancer after hysterectomy. Methods BMS-IMRT and IMRT plans were designed for a cohort of nine patients. The prescribed dose was 45 Gy in 1.8 Gy daily fractions, and 95% of the planned target volume received this dose. The doses were computed using a commercially available treatment planning system with the convolution/superposition algorithm. Plans were compared according to dose-volume histogram analysis in terms of planning target volume homogeneity and conformity indices(HI and CI) as well as organ at risk dose and volume parameters. Results BMS-IMRT had advantages over IMRT in terms of CI, but was equivalent to the latter in HI. V5, V10, V20, V30, and V40 of pelvic bone marrow in BMS-IMRT decreased by 0.06%, 17.33%, 22.19%, 13.85%, and 16.46%, respectively, compared with IMRT. Except for V30 of the small bowel and V30 and V40 of the bladder, no statistically significant differences were found between BMS-IMRT and IMRT in the small bowel, bladder, and rectum. Conclusion For cervical cancer patients receiving tomotherapy-based radiotherapy after hysterectomy, BMS-IMRT reduced pelvic bone marrow volume receiving low-dose radiation, and it may be conducive to preventing acute hematologic toxicity.     

Clinical presentation and long-term outcome of primary spinal peripheral primitive neuroectodermal tumors

Journal of Neuro-Oncology - Primary spinal peripheral primitive neuroectodermal tumors (pPNETs) are extremely rare entities that predominantly occur in children and young adults. Few studies have...     

IgM anti-preS2 monitoring during combined corticosteroid/interferon-alpha 2b therapy in chronic hepatitis B.

The biological significance of antibody reactivities towards the preS2 gene encoded proteins of HBV is not yet well known. We investigated the pretreatment IgM anti-preS2 (1-55) ad reactivity in 22 Chinese and 11 Swedish patients with active HBV disease. Significantly enhanced IgM anti-preS2 levels (titers greater than 1/1000) were observed in 48% (16/33) of these patients. The OD405 values for sera from patients with indolent HBsAg carriership were within the range of that obtained for "normal" control-sera when tested at dilutions from 1/1000 to 1/128,000. Five Chinese patients were treated with a short course of corticosteroids, followed by alpha-interferon 2b (IFN-alpha 2b) treatment for 16 weeks. The IgM anti-preS2 response was consecutively monitored during treatment. A beneficial effect on the outcome of the combined treatment was associated with rising titers of IgM anti-preS2 during the prednisolone cycle. The IgM anti-preS2 levels fell dramatically upon steroid withdrawal and were followed by a second peak response of IgM anti-preS2 reactivity during the IFN-alpha 2b treatment. No sustained loss of HBV-DNA or DNA polymerase with concomitant HBe/anti-HBe seroconversion was observed in treated patients, who lacked detectable pretreatment levels of IgM anti-preS2 in circulation.     

加校正因子的自身对照法测定淫羊藿饮片中6种成分含量

摘 要 目的： 采用加校正因子的自身对照法测定淫羊藿饮片中6种成分含量。方法: Agilent ZORBAX Eclipse XDB-C₁₈(150 mm×4.6 mm,5 μm)色谱柱,流动相为乙腈 水梯度洗脱,检测波长268 nm,柱温30℃。通过加入自身内标物色谱峰峰面积增加值建立校正因子,用相对保留时间和光谱对照法确定其他成分位置,采用HPLC色谱法对其他成分进行定量分析。结果:淫羊藿饮片中朝藿定A、朝藿定A1、朝藿定B、朝藿定C、宝藿苷Ｉ相对于淫羊藿苷的保留时间分别为0.750,0.810,0.865,0.939,1.651;校正因子分别为0.998 6,0.998 7,0.998 8,0.989 4,0.985 6。结论: 加校正因子的自身对照法可以用于相同类型化学环境成分的定量测定,该方法简便、快捷,适合中药多成分的定量分析。