扶正调平汤减轻化疗毒副反应的临床观察

目的研究在化疗过程中运用扶正调平汤对减轻肿瘤患者的骨髓抑制，消化道症状等化疗副反应的作用。方法通过临床对60例手术及非手术胃癌患者随机分成两组，即治疗组和对照组，观察化疗前后两组的血象变化、消化道反应情况，及其生活质量进行评定，比较、分析。结果实验证明化疗同时配合扶正调平汤对改善化疗副反应的作用显著化于对照组（P〈0．05）。结论说明扶正调平汤对减轻化疗毒副反应方面具有较好的临床疗效。提高了患者生活质量，使惠者顺利完成化疗疗程。     

归脾汤加减治疗病毒性心肌炎31例

笔者2000年10月～2005年5月,采用归脾汤治疗病毒性心肌炎31例,取得了较好的疗效,现总结如下.     

55例中药致肝损害的病例分析

目的重视中药致肝损害的不良反应，以保证临床用药安全。方法对55例中药引起的肝损害病例进行统计分析。结果患者年龄涉及各个年龄段，引起肝损害的药物以含何首乌和黄药子的中药为多，注射剂发生症状的时间较早，临床以消化道症状和黄疽为多见，多数患者在停药后经对症治疗肝功异常得到恢复或好转。结论控制肝损害中药的使用，用药时注意个体差异，慎重使用滋补类中药，临床密切观察肝功能，注意个别治疗肝炎的药物也会引起肝损害。     

Prognostic significance of caspase-3 expression in primary resected esophageal squamous cell carcinoma.

AIMS: The present study retrospectively examines the expression of caspase-3 in primary resected esophageal squamous cell carcinoma (ESCC) and the correlation between the outcome of patients and the expression of proteins. METHODS: Immunohistochemistry and Western blot analyses were used to analyse the expression of caspase-3 in 40 archival specimens of patients with primary resected ESCC. RESULTS: According to our cut-off point of the staining for caspase-3, 24 (60%) cases were positive and 16 (40%) negative. Caspase-3 expression correlated with a significant favorable prognosis in primary resected ESCC (P=0.02). A multivariate analysis of clinical and biological factors indicated that stage, tumor differentiation, and caspase-3 expression were independent prognostic factors. CONCLUSIONS: Caspase-3 expression might be a good and new prognostic indicator for primary resected ESCC.     

Heterogeneity of human blood monocyte: two subpopulations with different sizes, phenotypes and functions.

Human blood mononuclear cells from normal adults were collected after density-cut centrifugation and monocytes were then isolated by removal of lymphocytes using the techniques of E-rosetting and cell adhesion. The purified monocytes were further analysed by velocity sedimentation, and two distinct subpopulations with different cell sizes were obtained. The larger monocytes were 17.0 +/- 1.8 microns in diameter with a mean sedimentation rate (SR) of 7.0 +/- 0.6 mm/hr, while the smaller monocytes were 9.5 +/- 0.8 microns in size and 4.1 +/- 0.2 mm/hr in SR. The population ratio of larger:smaller cells was approximately 2:1 (66 +/- 2.8%:34 +/- 1.6%). Both cell populations exhibited a high positive rate (> 98%) in both the non-specific esterase and the peroxidase stain. However, the larger cells had much higher phagocytic activity than the smaller ones. Furthermore, the expression of monocyte-associated antigens was also different between these two subpopulations. Thus, while most of the larger monocytes (98%) could be recognized by monoclonal antibodies MY7 and OKM1, only some (35 and 61%, respectively) of the smaller monocytes could react with those antibodies. In addition, the larger monocytes secreted a significant amount of monokines including interleukin-1 beta (IL-1 beta), tumour necrosis factor-alpha (TNF-alpha) and prostaglandin E2 (PGE2) and their production increased in proportion to the level of stimulation by bacterial lipopolysaccharide (LPS), whereas the production of monokines by the smaller monocytes remained at low levels and did not respond to LPS stimulation. These results reveal the existence of phenotypic and functional heterogeneity in human blood monocytes.     

国产长效皮下埋植避孕剂的临床应用

1992年我院用国产长效皮下埋植避孕剂(左旋18-甲基炔诺酮),对600例育龄妇女进行皮下埋植,经1年随访,结果显示:国产长效皮下埋植剂的避孕效果达100％。600例中10例因出现月经异常而终止使用,其持续使用率为98.33％,获得了与进口长效皮下埋植避孕剂相同的效果。     

氨茶碱与盐酸洁霉素配伍应用考察

氨茶碱与盐酸洁霉素在大输液中的配伍实验,从物理变化方面,观测4h,外观无变化。混合后不同时间pH值基本不变。从化学变化方面,经过连续4h的紫外扫描测定, 单独组与混合组中的氨茶碱在λ274nm处的吸收峰一致,吸收值不变。从氨茶碱对盐酸洁霉素的抑菌效果看,差异不显著。薄层层析实验,单独组与混合组中各药,连续测定3h,Rf值完全一致。