Experimental Studyon Anti－tumor Effect of SplenocytesInduced by Anti－CD3McAb，PHA and IL－2

（沈张悦）（邵静芳）（王晓林）（朱慧芬）ＥｘｐｅｒｉｍｅｎｔａｌＳｔｕｄｙｏｎＡｎｔｉ－ｔｕｍｏｒＥｆｆｅｃｔｏｆＳｐｌｅｎｏｃｙｔｅｓＩｎｄｕｃｅｄｂｙＡｎｔｉ－ＣＤ３ＭｃＡｂ，ＰＨＡａｎｄＩＬ－２￥ＳＨＥＮＧｕａｎ－ｘｉｎ，ＷＡＮＧＸｉａｏ－ｌｉ...     

Study on lymphocyte activation and proliferation induced by anti-CD3 McAb

Summary T cell activation and proliferation via CD₃-TCR complex were investigated by lymphocyte DNA synthesis in vitro. Several interfering factors were also discussed. The result indicated that lymphocyte activation and proliferation are calciumdependent. A rise of cytoplasmic free Ca²⁺ quickly following activation with CD₃ McAb is mainly due to intracellular mobilization of Ca²⁺, while lymphocyte proliferation needs both intracellular mobilization of Ca²⁺ as well as influx of extracellular Ca²⁺. It was confirmed that CTX sensitive G protein plays a role in regulating T cell proliferation by pretreatment with CTX suppressing lymphocyte³H-TdR incorporation obviously. PLC and PKC inhibitor neomycin and P. S. S could also decrease T cell proliferation.     

The role of condylectomy in the treatment of mandibular laterognathism in children

In 7 cases of mandibular laterognathia caused by condylar hypertrophy, the authors specify the clinical and teleradiological features in adolescents. They emphasize the inadequacy of lateral teleradiography and of its measurements, and the need for three-dimensional investigation. In adolescents, secondary deformations, either spontaneous or therapeutic, are rare, and the treatment preferred is condylectomy based on the study of casts. The immediate results of this techniques are satisfactory. The long-term consequences on growth and temporomandibular pathology have been studied.     

Resolution of otitis media with effusion with the use of a stepped treatment regimen of trimethoprim-sulfamethoxazole and prednisone

This double blind, placebo-controlled trial was designed to determine whether intervention with a stepped regimen of trimethoprim-sulfamethoxazole (TMP-SMX) and prednisone would prevent high risk children from developing chronic otitis media with effusion (OME) and recurrent acute otitis media. Forty-two children were enrolled, assigned to treatment with active drug or placebo and then examined at 2-week intervals. They received TMP-SMX (or placebo) during the first 2 weeks, TMP-SMX and prednisone (or placebo) during Weeks 3 and 4 for persistent OME and TMP-SMX (or placebo) for Weeks 5 and 6 if OME was still unresolved. After treatment 48% of active drug and 14% of placebo subjects resolved OME bilaterally (P less than 0.05). Active drug subjects also had fewer acute otitis media episodes than placebo subjects while receiving study treatment (P less than 0.01). Although this treatment regimen produced short term OME resolution, long term benefits were not demonstrated.     

Hemorrhagic fever with renal syndrome virus infection in livers studied by in situ hybridization and immunohistochemistry

ＨｅｍｏｒｒｈａｇｉｃｆｅｖｅｒｗｉｔｈｒｅｎａｌｓｙｎｄｒｏｍｅｖｉｒｕｓｉｎｆｅｃｔｉｏｎｉｎｌｉｖｅｒｓｓｔｕｄｉｅｄｂｙｉｎｓｉｔｕｈｙｂｒｉｄｉｚａｔｉｏｎａｎｄｉｍｍｕｎｏｈｉｓｔｏｃｈｅｍｉｓｔｒｙＹａｎｇＳｈｏｕｊｉｎｇ（杨守京）；Ｌ...     

角膜移植术护理探讨

以１５例角膜移植术的护理实践，总结出该手术的护理常规，并对本组病例中发生的并发症的护理进行了讨论，强调护士密切观察病情，有效地处理并嫌下对手术成功的重要性。     

Comparison of the treadmill exercise score and single-photon emission computed tomographic thallium imaging in risk assessment

Background  

This study compared the prognostic value of exercise single-photon emission computed tomographic (SPECT) thallium imaging with that of treadmill exercise score in medically treated patients with coronary artery disease (CAD)     

凝集素受体在膀胱癌中的分布

目的：探讨膀胱癌中凝集素受体分布与其分化程度和浸润深度的关系。方法：应用生物素标记的花生凝集素（ＰＮＡ）、麦胚凝集素（ＷＧＡ）及刀豆凝集素（ＣｏｎＡ）等３种凝集素对５２例人体膀胱癌、１０例正常人体膀胱粘膜，进行亲合组织化学法研究。结果：发现正常膀胱粘膜ＰＮＡ、ＷＧＡ受体阴性，ＰＮＡ受体阳性率随膀胱癌病理分级的上升而递增，差异具有显著性意义（Ｐ＜０．０５）。ＰＮＡ、ＷＧＡ受体阳性率在浸润性肿瘤中明显高于浅表性肿瘤（Ｐ＜０．０５）。结论：提示ＰＮＡ、ＷＧＡ受体阳性率与膀胱癌分化程度和浸润深度有关。