全文获取类型
收费全文 | 520054篇 |
免费 | 36999篇 |
国内免费 | 11106篇 |
专业分类
耳鼻咽喉 | 6378篇 |
儿科学 | 10164篇 |
妇产科学 | 12575篇 |
基础医学 | 70261篇 |
口腔科学 | 14342篇 |
临床医学 | 47957篇 |
内科学 | 101848篇 |
皮肤病学 | 10212篇 |
神经病学 | 35775篇 |
特种医学 | 18859篇 |
外国民族医学 | 154篇 |
外科学 | 75888篇 |
综合类 | 29421篇 |
现状与发展 | 25篇 |
一般理论 | 73篇 |
预防医学 | 26376篇 |
眼科学 | 13449篇 |
药学 | 45160篇 |
116篇 | |
中国医学 | 8337篇 |
肿瘤学 | 40789篇 |
出版年
2022年 | 5942篇 |
2021年 | 8695篇 |
2020年 | 5967篇 |
2019年 | 6935篇 |
2018年 | 8855篇 |
2017年 | 7309篇 |
2016年 | 7145篇 |
2015年 | 9445篇 |
2014年 | 12479篇 |
2013年 | 13967篇 |
2012年 | 19555篇 |
2011年 | 20635篇 |
2010年 | 12556篇 |
2009年 | 10926篇 |
2008年 | 16612篇 |
2007年 | 17539篇 |
2006年 | 17396篇 |
2005年 | 16372篇 |
2004年 | 13800篇 |
2003年 | 13250篇 |
2002年 | 12200篇 |
2001年 | 32296篇 |
2000年 | 32955篇 |
1999年 | 27927篇 |
1998年 | 7678篇 |
1997年 | 6602篇 |
1996年 | 5602篇 |
1995年 | 5117篇 |
1994年 | 4519篇 |
1993年 | 3805篇 |
1992年 | 17759篇 |
1991年 | 16283篇 |
1990年 | 15454篇 |
1989年 | 15207篇 |
1988年 | 13662篇 |
1987年 | 13008篇 |
1986年 | 11880篇 |
1985年 | 11071篇 |
1984年 | 7373篇 |
1983年 | 5953篇 |
1982年 | 2929篇 |
1979年 | 5731篇 |
1978年 | 3477篇 |
1977年 | 3088篇 |
1975年 | 2759篇 |
1974年 | 3197篇 |
1973年 | 2990篇 |
1972年 | 2934篇 |
1971年 | 2883篇 |
1969年 | 2613篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
Esin Benli Küçük Ercan Kaydok Kürsad Ramazan Zor Gamze Yıldırım Biçer 《Topics in stroke rehabilitation》2020,27(8):630-635
ABSTRACT Objective: Dry eye is reported to be associated with several neurological diseases. The aim of this study is to evaluate the patients with hemiplegia after stroke for dry eye and compare their results with a control group. Materials and methods: Forty-five patients with hemiplegia and 45 individuals as the control group were included in the study. Tear function tests (Schirmer and tear breakup time) and a dry eye questionnaire for dry eye symptoms (ocular surface disease index) were performed and the results of the two groups were compared. Results: Schirmer test results were significantly lower in the post-stroke hemiplegia group compared to the control group (11.3 ± 8.2 mm and 20.6 ± 11.6 mm, respectively, p < .001). Tear breakup time results were significantly lower in the post-stroke hemiplegia group compared to the control group (7.9 ± 3.1 s and 12.1 ± 4.3 s, respectively, p < .001). Ocular surface disease index scores were not significantly different between hemiplegia and control groups (21.6 ± 20.0 and 19.8 ± 13.9, respectively, p = .635). Schirmer scores lower than 10 mm (60% and 30%, p < .001) and tear breakup time results lower than 10 s (65.6% and 28.9%, p < .001) were also higher in the hemiplegia group compared to control group. Conclusion: We found lower Schirmer test and tear breakup time results and similar OSDI scores in hemiplegia patients compared to controls. Hemiplegia patients may have dry eye without typical symptoms. This should be taken into consideration in the follow-up and rehabilitation of post-stroke hemiplegia patients. 相似文献
12.
13.
15.
16.
We report a Chinese family with members affected by epidermolytic ichthyosis (EI), caused by KRT gene mutations. The proband was a 14‐year‐old boy who had simultaneous appearance of nephroblastoma and epidermolytic ichthyosis (EI). Both the patient and his mother exhibited the specific clinical and pathological manifestations of EI. We analysed all exons and flanking sequences of the KRT1 and KRT10 genes using PCR, and found that the proband and his mother had a G>C transition at nucleotide position 1432 in exon 7 of KRT1, resulting in an amino acid substitution of glutamate (GAA) to glutamine (CAA) at codon 478 (E478Q). The KRT10 gene had no mutations. 相似文献
17.
Autoimmune comorbid diseases associated with lichen planus: a nationwide case–control study 下载免费PDF全文
18.
Loss‐of‐function mutations in the gene encoding filaggrin underlie a Japanese family with food‐dependent exercise‐induced anaphylaxis 下载免费PDF全文
19.
20.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献