Comparative study of micro-transplantation from HLA fully mismatched unrelated and partly matched related donors in acute myeloid leukemia

Micro-transplantation (MST) by chemotherapy, combined with granulocyte colony-stimulating factor-mobilized peripheral blood stem cell (GPBSC) infusion, from an HLA partial matched related donor has shown some encouraging effective therapy for acute myeloid leukemia (AML). However, the outcome of human leukocyte antigen (HLA) fully mismatched unrelated donor-derived MST in such patients is still unknown. In the present study, we compared the efficacy of HLA fully mismatched unrelated donor-derived MST, and partly matched related donor-derived MST, in AML of 126 patients from two centers in China, These patients, aged 16 to 65 years, were given three or four courses of MST, which consisted of a high dosage cytarabine followed by GPBSC from unrelated donor or related donor. There was a statistically significant difference in 3-year leukemia-free survival (LFS) and 3-year overall survival (OS) between the unrelated and the related group. The non-treatment-related mortality (NRM) rates of patients, and other adverse complications, were no different in the two groups. In conclusion, unrelated donor-derived MST is believed to be a safe treatment, with efficacy similar to or higher than related donor-derived MST. This result provides support for the potential of MST for expanding the donor selection. However, the specific mechanism of action needs further study.     

Contrast-enhanced ultrasound for evaluating arteritis activity in Takayasu arteritis patients

Clinical Rheumatology - Contrast-enhanced ultrasound (CEUS) was recently used to evaluate vascularization within the carotid artery wall, and this process of vascularization was correlated with...     

A complex COVID-19 case with rheumatoid arthritis treated with tocilizumab

Clinical Rheumatology - Recurrences of COVID-19 were observed in a patient with long-term usage of hydroxychloroquine, leflunomide, and glucocorticoids due to her 30-year history of rheumatoid...     

广州市大学城诺如病毒GⅡ.4 Sydney 2012变异株感染疫情再次暴发的调查

2013 年1 月广州市大学城ZD 大学暴发国内首起诺如病毒GⅡ.4 Sydney 2012 变异株感染引起的急性胃肠炎疫情。2 个月后该地区其他4 所高校（HS、HG、GD、GG）和1所中学（GDFZ）相继又出现暴发。     

全机器人辅助低温灌注下肾部分切除术的护理配合

目的：探讨全机器人辅助低温灌注下肾部分切除术下的护理配合流程,提高护士的手术配合质量。方法通过配合10例全机器人辅助低温灌注下肾部分切除手术,对术前物品准备、手术间布局,术中体位摆放及手术精准配合进行总结。结果10例手术顺利完成,无中转开腹,手术配合满意。结论准备好特殊手术物品,熟练的手术操作步骤,与手术医生积极沟通,掌握机器人各系统的使用情况是确保手术成功的关键。     

2例感染性腹主动脉瘤合并主动脉肠瘘患者行“牛心包”原位重建术的护理

目的 总结2例感染性腹主动脉瘤合并主动脉肠瘘行牛心包原位重建术后治疗护理经验。方法 术前实施血压进阶式管理,降低血管破裂风险;严格落实消毒隔离措施,注意多种药物不良反应;术后实施个体化营养方案,实施全程管理预防再感染,延续药物重整服务;严防吻合口破裂出血及下肢动脉栓塞。结果 经过积极的治疗和护理,2例患者恢复良好,顺利康复出院。微信、电话随访半年,患者恢复良好。结论 腹主动脉瘤合并主动脉肠瘘患者病情复杂而危重,提供个体化围术期全程管理,降低感染等并发症发生率,可为临床工作提供借鉴及参考。